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排序方式: 共有192条查询结果,搜索用时 523 毫秒
1.
Miaomiao Shen Yanshen Nie Yueyue Chen Xiufeng Zhang Jie Zhao 《International journal of molecular sciences》2021,22(1)
Meiotic recombination 11 (Mre11) is a relatively conserved nuclease in various species. Mre11 plays important roles in meiosis and DNA damage repair in yeast, humans and Arabidopsis, but little research has been done on mitotic DNA replication and repair in rice. Here, it was found that Mre11 was an extensively expressed gene among the various tissues and organs of rice, and loss-of-function of Mre11 resulted in severe defects of vegetative and reproductive growth, including dwarf plants, abnormally developed male and female gametes, and completely abortive seeds. The decreased number of cells in the apical meristem and the appearance of chromosomal fragments and bridges during the mitotic cell cycle in rice mre11 mutant roots revealed an essential role of OsMre11. Further research showed that DNA replication was suppressed, and a large number of DNA strand breaks occurred during the mitotic cell cycle of rice mre11 mutants. The expression of OsMre11 was up-regulated with the treatment of hydroxyurea and methyl methanesulfonate. Moreover, OsMre11 could form a complex with OsRad50 and OsNbs1, and they might function together in non-homologous end joining and homologous recombination repair pathways. These results indicated that OsMre11 plays vital roles in DNA replication and damage repair of the mitotic cell cycle, which ensure the development and fertility of rice by maintaining genome stability. 相似文献
2.
为对远距离的直流移动负载进行供电,须考虑损耗、体积、指标等一系列的问题。要解决远距离损耗大的问题,则须采用在始端升压、负载端降压的措施;要使负载端的变换器体积小,则须提高系统频率,在变换器中采用高频变压器;要满足整个系统的指标,则须完成从部分到整体的设计过程。在此基础上,此供电电源采用AC/DC/DC变换的过程,始端变换器中采用三相PWM斩波稳压与12脉波整流相结合输出高压直流,然后经过远距离的电缆,负载端DC/DC变换器采用半桥三电平结构进行直流降压后为移动负载供电。文中分别对两个部分的拓扑以及工作原理进行了理论分析与仿真,仿真结果表明,供电电源采用这样的拓扑结构能够得到稳定的直流电压,并且不会影响始端的交流指标。 相似文献
3.
通过分析心音信号对心脏早期的病理状态进行确诊具有重要的意义。提出了一种基于深度卷积神经网络的心音分类方法。将心音信号转化成具有时频特性的梅尔频谱系数(Mel Frequency Spectral Coefficient,MFSC)特征图,将其作为深度卷积神经网络模型的输入;利用深度卷积神经网络对MFSC特征图进行训练,引入中心损失函数建立最优的深度学习模型;测试阶段,先将心音信号转换成多张二维MFSC特征图,然后利用训练好的深度学习模型对其分类,最后利用多数表决原则判断心音信号的类别。针对人工标注的训练样本有限,导致模型训练正确率不高的问题,以心音的二维MFSC特征图为对象分别从时间域和频率域进行随机屏蔽处理进而扩充训练样本。实验结果表明,该方法在PASCAL心音数据集上进行测试,对正常、杂音、早搏三种心音的分类性能明显优于现有最好的方法。 相似文献
4.
朱玥玥 《湖北工业大学学报》2015,(3):33-37
近年来,我国农村群体性事件频频发生并呈现出螺旋上升态势。处于社会转型期的农村,其各种矛盾冲突提档升级,群体性事件频频见诸报端,愈演愈烈,不仅严重制约着社会主义和谐新农村建设的步伐,也给基层政府的治理提出了严峻考验。以新时期农村经济社会的发展趋势为时代背景,深度挖掘解决农村群体性事件的应然之义,探寻新时期农村群体性事件的实然之路,提出解决农村群体性事件的必然之策,为新时期农村群体性事件的政府治理提供理论依据。 相似文献
5.
Yueyue Wang Feifei Qin Junfeng Lu Jitao Li Zhu Zhu Qiuxiang Zhu Ye Zhu Zengliang Shi Chunxiang Xu 《Nano Research》2017,10(10):3447-3456
It is essential to develop a single mode operation and improve the performance of lasing in order to ensure practical applicability of microlasers and nanolasers.In this paper,two hexagonal microteeth with varied nanoscaled air-gaps of a ZnO microcomb are used to construct coupled whispering-gallery cavities.This is done to achieve a stable single mode lasing based on Vernier effect without requiring any complicated or sophisticated manipulation to achieve positioning with nanoscale precision.Optical gain and the corresponding ultraviolet lasing performance were improved greatly through coupling with localized surface plasmons of Pt nanoparticles.The ZnO/Pt hybrid microcavities achieved a seven-fold enhancement of intensity of single mode lasing with higher sidemode suppression ratio and lower threshold.The mechanism that led to this enhancement has been described in detail. 相似文献
6.
7.
Hydrogen is an energy carrier that has the potential to improve the sustainability of transportation fuels and reduce oil dependence. This paper presents a stochastic dynamic programming model for sequentially building a hydrogen production and distribution system. The decision variables are the sequence and locations of the central production sites and the corresponding distribution systems from supply to demand sites. A case study based on the geographic setting of Northern California is included, in which the hydrogen is produced via coal gasification and transported from plant to city gates (demand sites) by cryogenic liquid hydrogen trucks. Future demands for hydrogen are modeled as uncertain parameters, with an assumption that hydrogen fuel cell vehicle (HFCV) market penetration rate increases from 1% to 25% over a 20-year period. This model provides multistage decision support for long term transportation energy planning at national and regional levels. 相似文献
8.
This research focuses on pre-disaster transportation network protection against uncertain future disasters. Given limited
resources, the goal of the central planner is to choose the best set of network components to protect while allowing the network
users to follow their own best-perceived routes in any resultant network configuration. This problem is formulated as a two-stage
stochastic programming problem with equilibrium constraints, where the objective is to minimize the total expected physical
and social losses caused by potential disasters. Developing efficient solution methods for such a problem can be challenging.
In this work, we will demonstrate the applicability of progressive hedging-based method for solving large scale stochastic
network optimization problems with equilibrium constraints. In the proposed solution procedure, we solve each modified scenario
sub-problem as a mathematical program with complementary constraints and then gradually aggregate scenario-dependent solutions
to the final optimal solution. 相似文献
9.
电机电流分析法在机床类设备诊断中的应用研究 总被引:2,自引:0,他引:2
机床类设备传动链复杂,结构紧凑且封闭,对传动系统状态监测一直没有有效的分析办法,即使在噪声增大等恶劣情况下,常规的振动诊断方法也难以奏效.本文尝试用电流信号分析法,简称MCSA(Motor Current Signal Analysis),对机床状态进行测试和分析.通过电机电流信号的传动链齿轮谱特征分析,对其做出了正确评估,表明定子电流能很好地反映机床传动系统部件的运行状况.同时进行了多种运行工况的测试与试验,研究结论对机床类设备的生产制造和现场运行状态的分析提供了有效依据. 相似文献
10.
以一定化学计量比均匀混合的Si、Ge、B混合粉末为原材料,使用放电等离子烧结(SPS)一步法合金化制备了p型Si80Ge20Bx(x=0.5,1.0,2.0)合金热电材料,并对样品的组成、微观形貌、热电性能进行了表征与分析。结果表明,放电等离子烧结过程实现原位合金化并烧结为块体材料。随着B掺杂量的增加,电导率明显提升,热导率显著下降,当温度为950K时,热导率为1.79W/(m·K)。在1050K时,ZT值达到了0.899。球磨和掺杂的协同作用使得SiGe合金基体内产生不同类型的缺陷特征而散射不同波长的声子,导致硅锗合金热导率的降低。 相似文献