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31.
CT Lai VA Tanay GA Rauw AN Bateson IL Martin GB Baker 《Canadian Metallurgical Quarterly》1997,704(1-2):175-179
Reported here is a rapid, sensitive and relatively inexpensive procedure using gas chromatography with nitrogen-phosphorus detection (GC-NPD) to quantify buspirone levels in brains of rats. The analyte was directly extracted from brain homogenate with toluene after basification and then subjected to GC-NPD analysis using a capillary column. The calibration curves were linear over the range of 10 to 320 ng per 2 ml of brain homogenate, with typical r2 values >0.99. The assay was highly reproducible and gave peaks with excellent chromatographic properties. 相似文献
32.
M Cuchacovich NN Tchernitchin H Gatica R Wurgaft L Contreras AN Tchernitchin 《Canadian Metallurgical Quarterly》1996,124(2):160-169
BACKGROUND: The target cellular response to glucocorticoids is proportional to the concentrations or affinity of specific receptors to these substances. AIM: To look for a correlation between glucocorticoid receptor concentrations in synovial wall cells and the clinical response to steroidal treatment in patients with rheumatoid arthritis. PATIENTS AND METHODS: Twenty eight patients with rheumatoid arthritis were studied. Each subject was subjected to a synovial biopsy, in which a dry radioautographic technique for diffusible compounds was used. Patients were treated afterwards with three 500 mg intravenous pulses of methilprednisolone. RESULTS: A mean of 44.8% of synovial cells (range 30.1-62.8%) had binding sites for 3H dexamethasone. All patients had a significant clinical improvement after methylprednisolone. Multiple regression analysis did not show a correlation between clinical response and glucocorticoid receptor concentration. CONCLUSIONS: The lack of association between glucocorticoid receptor concentrations and clinical response could be due to the large steroid dose used, that saturated all available receptors. 相似文献
33.
Gluconobacter oxydans possesses a unique organization of metabolic systems, which are characterized by reduction of major dissimilation pathways, surface localization of main oxidative enzymes responsible for partial oxidation of carbon substrates, high performance of electron-transport chains, and accumulation of partially oxidized metabolites in the medium. These features allow us to use the cells of these microorganisms in biotechnology for production of several food products and medicines. The use of G. oxydans in biosensors for estimation of concentrations of sugars, aldoses and polyalcohols is promising. Physiological and biochemical features of these microorganisms enabling their use in biotechnology and receptor elements of biosensors are reviewed. 相似文献
35.
目前反倾岩质边坡弯曲倾倒破坏分析方法仍以基于极限平衡理论的悬臂梁模型为主,但大多未考虑坡脚岩层的剪切破坏。为准确评价该类边坡的稳定性,建立考虑坡脚岩层剪切破坏的分析计算方法。首先,根据岩层变形破坏特征,将边坡分为后缘稳定区、中部弯曲倾倒区和前缘剪切区3个区域;其次,建立弯曲倾倒-剪切滑移破坏模式的稳定性分析方法;最后,通过工程实例验证,并进行参数分析。研究结果表明:提出的分析方法与工程实际符合性较好;边坡在倾角较陡、坡角较大时稳定性最差,坡角对边坡稳定性影响大于岩层倾角的影响;岩层厚度及层面内摩擦角增加有利于边坡稳定性,且会扩大坡脚剪切区范围。研究成果对反倾岩质边坡破坏的防治具有实践指导意义。 相似文献
36.
1 Introduction The tunnel is one of the important facilities of railroad and highway transportation, and also a throat of railroad and highway. With the development of transportation, there are more and more tunnels. Although the tunnel fire occurs seldo… 相似文献
37.
昆明冶金高等专科学校冶金材料专业群通过"三方七步"工作路线构建校企深度融合的订单式人才培养模式,初步实现了专业与产业对接、学校与企业对接、课程内容与职业标准对接、教学过程与生产过程对接,育人特色明显,校企合作效果显著,模式富有创新亮点. 相似文献
38.
It is demonstrated that the nickel can be deposited directly on the surface of carbon nanotubes without pre-sensitization by Sn^2+ and Pd^2+ in a watt bath containing suspended nanotubes by electroplating. The nickel is deposited as spherical nanoparticle on the nanotubes. By increasing reaction time, the carbon nanotube is fully coated with nickel. A probable model, which represents the formation process of carbon nanotube-nickel composites by electroplating, is presented. The results show that this method is efficient and simple for preparing carbon nanotube-metal composite. 相似文献
39.
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