全文获取类型
收费全文 | 617篇 |
免费 | 46篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 11篇 |
综合类 | 1篇 |
化学工业 | 203篇 |
金属工艺 | 14篇 |
机械仪表 | 15篇 |
建筑科学 | 15篇 |
能源动力 | 21篇 |
轻工业 | 55篇 |
水利工程 | 1篇 |
无线电 | 52篇 |
一般工业技术 | 78篇 |
冶金工业 | 56篇 |
原子能技术 | 3篇 |
自动化技术 | 139篇 |
出版年
2024年 | 2篇 |
2023年 | 16篇 |
2022年 | 32篇 |
2021年 | 76篇 |
2020年 | 23篇 |
2019年 | 21篇 |
2018年 | 27篇 |
2017年 | 21篇 |
2016年 | 28篇 |
2015年 | 19篇 |
2014年 | 32篇 |
2013年 | 34篇 |
2012年 | 38篇 |
2011年 | 41篇 |
2010年 | 29篇 |
2009年 | 33篇 |
2008年 | 33篇 |
2007年 | 18篇 |
2006年 | 17篇 |
2005年 | 9篇 |
2004年 | 11篇 |
2003年 | 6篇 |
2002年 | 5篇 |
2001年 | 5篇 |
2000年 | 6篇 |
1999年 | 5篇 |
1998年 | 12篇 |
1997年 | 7篇 |
1996年 | 6篇 |
1995年 | 12篇 |
1994年 | 4篇 |
1993年 | 8篇 |
1992年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有664条查询结果,搜索用时 703 毫秒
51.
We investigate the generation of squeezing and entanglement for the motional degrees of freedom of ions in linear traps, confined
by time-varying and oscillating potentials, comprised of a DC and an AC component. We show that high degrees of squeezing
and entanglement can be obtained by controlling either the DC or the AC trapping component (or both), and by exploiting transient
dynamics in regions where the ions’ motion is unstable, without any added optical control. Furthermore, we investigate the
time-scales over which the potentials should be switched in order for the manipulations to be most effective. 相似文献
52.
53.
In this paper the authors review the developments of the analytic hierarchy process (AHP) since its inception. The focus of this paper is a neutral review on the methodological developments rather than reporting its applications that have appeared since its introduction. In particular, we discuss problem modelling, pair-wise comparisons, judgement scales, derivation methods, consistency indices, incomplete matrix, synthesis of the weights, sensitivity analysis and group decisions. All have been important areas of research in AHP. 相似文献
54.
55.
56.
BACKGROUND: There are many causes of ulcer of the lower limb. In the elderly, venous ulcers and arteriosclerosis often coexist; for this reason pressure bandages might be contraindicated for the risk of precipitating a potentially critical arterial flow. In this work, the conditions which allow a safely treatment with pressure bandage in the elderly are evaluated. MATERIAL AND METHOD: Eleven self-sufficient elderly, with venous ulcerations to one leg only, and ankle pressure/omeral pressure between 0.92 and 0.86 were treated with elastic bandaging of the leg. RESULTS: All patients completed the treatment, with healing of the ulcer obtained in 3-8 months time. So far none of them relapsed. CONCLUSIONS: In the elderly, in selected cases, when Pc/Po > 0.86, pressure bandages can be safely applied to heal the ulcer, without running the risk of endangering arterial circulation. 相似文献
57.
CG Strano C Polito M Alessio C Servodio Iammarrone A Di Toro N Todisco A Marotta 《Canadian Metallurgical Quarterly》1995,84(9):1010-1013
Nutritional status and nutrient intake were assessed in 17 children with active juvenile chronic arthritis (JCA) who never received steroids and in 17 controls matched for age and sex. Five patients had systemic, seven polyarticular and five oligoarticular JCA. Values significantly below those of the controls were found in systemic patients for height (p<0.05), upper arm circumference (p<0.05) and arm muscle area (p<0.01), and in polyarticular subjects for arm muscle area (p<0.01). All patients had unremarkable anthropometric fat measurements. All anthropometric measurements were normal in oligoarticular patients. Twelve JCA patients had reduced serum iron (Fe), 6 reduced serum zinc (SZn), 14 reduced intra-erythrocytic zinc (EZn) and 2 reduced serum copper (SCu). SZn was inversely correlated with erythrocyte sedimentation rate (ESR) (p=0.023). EZn was inversely related to lymphocyte count (p=0.022). SCu was related to ESR (p=0.037) and to lymphocyte count (p=0.016). No significant difference in nutrient intake was found between patients and controls. Active JCA was associated with reduced muscular mass, Fe, SZn, EZn. These alterations did not depend on reduced nutrient intake. 相似文献
58.
V. Ariola L. Campajola A. D'Alessandro P. Del Carmine F. Gagliardi F. Lucarelli P. A. Mand G. Marcazzan R. Moro S. Nava P. Prati G. Valli R. Vecchi A. Zucchiatti 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2002,190(1-4):471-476
The composition of particulate matter in the atmosphere of four major Italian towns (Florence, Genoa, Milan and Naples) has been studied with the extensive application of IBA techniques. The aerosol has been collected simultaneously in the four towns during the first weeks of year 2001, by two-stage continuous streaker samplers, which provide the separation of the particulate matter in two fractions. The concentrations in air of about 20 elements, and the total particulate mass, have been extracted in the PM2.5 and PM10 fractions with hourly resolution by PIXE, PIGE and optical analyses of about 2700 samples. IBA analyses have been performed at the 3 MeV external proton beam of the INFN accelerator facility at the University of Florence. 相似文献
59.
Roberta D’Ambrosio Alessio Aghemo Raffaele De Francesco Maria Grazia Rumi Enrico Galmozzi Stella De Nicola Cristina Cheroni Paul J. Clark Guido Ronchi Pietro Lampertico Massimo Colombo 《International journal of molecular sciences》2014,15(5):7213-7224
The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients.
Materials and Methods
Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as <5% or ≥5%. IL28B was typed by Taqman Single Nucleotide Polymorphism (SNP) genotyping assay. HCV genotype was 1 in 151 (45%), 2 in 99 (30%), 3 in 50 (15%) and 4 in 35 (10%) patients. IL28B genotype was CC in 117 (34%), CT in 166 (49%) and TT in 52 (15%). At univariate analysis, the IL28B CC genotype was associated with severe portal inflammation in HCV-1 patients (CC vs. CT/TT: 86% vs. 63%, p = 0.005), severe lobular inflammation in HCV-2 patients (CC vs. CT/TT: 44% vs. 23%, p = 0.03), and less fatty infiltration in HCV-1 patients (CC vs. CT/TT: 72% vs. 51%, p = 0.02). Despite the lack of any association between IL28B and fibrosis stage, in HCV-3 patients IL28B CC correlated with METAVIR F3–F4 (CC vs. CT/TT: 74% vs. 26%, p = 0.05). At multivariate analysis, the genotype CC remained associated with severe portal inflammation in HCV-1, only (Odds Ratio (OR): 95% Confidence Interval (CI): 3.24 (1.23–8.51)). IL28B genotype is associated with the histological features of chronic hepatitis C in a HCV genotype dependent manner, with CC genotype being independently associated with severe portal inflammation. 相似文献60.
Target Hopping as a Useful Tool for the Identification of Novel EphA2 Protein–Protein Antagonists
下载免费PDF全文
![点击此处可从《ChemMedChem》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Daniele Pala Dr. Simonetta Russo Dr. Riccardo Castelli Dr. Iftiin Hassan‐Mohamed Dr. Carmine Giorgio Dr. Alessio Lodola 《ChemMedChem》2014,9(1):67-72
Lithocholic acid (LCA), a physiological ligand for the nuclear receptor FXR and the G‐protein‐coupled receptor TGR5, has been recently described as an antagonist of the EphA2 receptor, a key member of the ephrin signalling system involved in tumour growth. Given the ability of LCA to recognize FXR, TGR5, and EphA2 receptors, we hypothesized that the structural requirements for a small molecule to bind each of these receptors might be similar. We therefore selected a set of commercially available FXR or TGR5 ligands and tested them for their ability to inhibit EphA2 by targeting the EphA2‐ephrin‐A1 interface. Among the selected compounds, the stilbene carboxylic acid GW4064 was identified as an effective antagonist of EphA2, being able to block EphA2 activation in prostate carcinoma cells, in the micromolar range. This finding proposes the “target hopping” approach as a new effective strategy to discover new protein–protein interaction inhibitors. 相似文献