A Review on the Role of miR-149-5p in the Carcinogenesis

miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the “guide” and the sister “passenger” strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.     

Recent Developments in Predicting Impact and Shock Sensitivities of Energetic Materials （英）

Empirical, quantum mechanical and artificial neural network methods are three usual methods in recent years that were used to predict sensitivity of different classes of high explosives. Some recent developments in predicting sensitivity by various methods are reviewed and discussed for various classes of energetic materials.     

In situ emulsion polymerization and characterization of PVAc nanocomposites including colloidal silica nanoparticles for wood specimens bonding

Polyvinyl acetate (PVAc) nanocomposites for wood adhesives containing different amounts of colloidal silica nanoparticles (CSNs) were synthesized via in situ one-step emulsion polymerization. The adhesion strength of wood specimens bonded by PVAc nanocomposites was investigated by the tensile test. Thermal properties of PVAc nanocomposites were also characterized by differential scanning calorimetry and thermogravimetric analysis. Rheological and morphological properties of the PVAc nanocomposites were investigated using rheometric mechanical spectrometry and field emission scanning electron microscopy (FESEM), respectively. The obtaining results showed that the shear strength of PVAc nanocomposite including 1 wt. % CSNs has the highest shear and tensile strength about 4.7 and 3.2 MPa, respectively. A small increment of T_g (~3 °C) and considerable increment of the ash content proved the enhancement of PVAc thermal characterization in the presence of CSNs. FESEM results showed uniform dispersion of nanoparticles throughout the PVAc matrix due to using the in situ emulsion polymerization process. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48570.     

Catalytic olefin polymerisation at short times: Studies using specially adapted reactors

Despite the fact that the very early stages (several tens of seconds) of catalysed olefin polymerisation processes appear negligibly short with respect to the residence time of most industrial reactors, they are critical in terms of catalyst activation, obtaining good particle morphology, and avoiding irreparable problems caused by particle overheating. The different types of reactors that have been used over the course of the past few years are discussed in this feature article. It is shown that despite the difficulties encountered in finding the perfect experimental tool for this purpose, different configurations of stopped flow reactors can be used successfully to explore different aspects of what happens to the catalyst (supported and molecular) during these critical moments of polymerisation. © 2012 Canadian Society for Chemical Engineering     

Amine corrosion and amine cracking of API 5L X52 carbon steel in the presence of hydrogen sulphide and carbon dioxide

In this research, stress corrosion cracking (SCC) and corrosion behaviour of API 5L X52 carbon steel in 25?wt-% diethanolamine solution, saturated/unsaturated with carbon dioxide and containing 0 and 200?ppm hydrogen sulphide at different temperatures were investigated using slow strain rate test, electrochemical measurement and microscopic analysis. In addition, the presence of heat stable amine salts (HSASs) in the test solution was studied using spectrophotometry and Fourier transform infra-red spectroscopy. Analysis of the results showed that the primary components to form HSASs exist in the solution. The results indicated that SCC is more likely in solutions without amine. Increase in corrosion rate of carbon steel by increase in temperature was clearly observed and concluded that the simultaneous presence of hydrogen sulphide and carbon dioxide in the solution can increase the corrosion rate of carbon steel more than having one of the gases in the solution.     

Self-esteem stability and depressive symptoms in acute stroke rehabilitation: Methodological and conceptual expansion.

Objectives: Explore the relationship of self-esteem level, self-esteem stability, and other moderating variables with depressive symptoms in acute stroke rehabilitation. Measures: One hundred twenty participants completed measures of state self-esteem, perceived recovery, hospitalization-based hassles, impairment-related distress, and tendency to overgeneralize negative self-connotations of bad events. Self-report of depressive symptoms was collected at admission and on discharge. Four regression analyses explored the relationship of self-esteem level and stability and each of 4 moderating variables (perceived recovery, hassles, impairment-related distress, and overgeneralization) with depressive symptoms at discharge. Results: Analyses indicated significant 3-way interactions in the 4 regression models. In general, individuals with unstable high self-esteem endorsed greater depressive symptoms under conditions of vulnerability (e.g., lower perceived recovery) than did individuals with stable high self-esteem. Under conditions of vulnerability, participants with stable low self-esteem indicated the highest levels of depressive symptoms. Implications: Self-esteem level and stability interact with psychological, environmental, and stroke-specific variables to predict depressive symptoms at discharge from stroke rehabilitation. This suggests the viability of self-esteem stability in exploring depressive symptoms in this setting and the complexity of emotional adjustment early after stroke. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Nanoscale vibration analysis of embedded multi-layered graphene sheets under various boundary conditions

The present article deals with the vibrational analysis of multi-layered graphene sheets with different boundary conditions amongst sheets. An elastic multiple-plate model is utilized in which the nested plates are coupled with each other through the van der Waals interlayer force. The interaction of van der Waals forces between adjacent and non-adjacent layers and the reaction from the surrounding media are included in the Reissner–Mindlin-type field equations on which the theoretical formulation is based. The set of coupled equations of motion for the multi-layered graphene sheets is then solved by the generalized differential quadrature method. The numerical analysis presented herein provides the possibility of considering various combinations of layerwise boundary conditions in a multi-layered graphene sheet. Based on exact solution, explicit formulas for the frequencies of a double-layered graphene sheet with all edges simply supported are also obtained. The results of the present numerical solution are shown to be in excellent agreement with those of exact solution for simply supported graphene sheets.     

Terrorist targeting and energy security

Sudden, short-term disruptions seriously endangering energy security can be triggered by a variety of events—among them attacks by terrorists. This study investigates terrorist attack practices against energy infrastructures and discusses how we may understand them. Our results indicate that attacks against energy infrastructures are comparatively few. Also, we find no strong connection between the ideologies of various terrorist groups and their proclivity to attack. In addition, the highly disproportionate number of attacks in a handful of countries highlights the strong geographic concentration of attacks. To explain these findings, we analyze terrorist targeting incentives including intimidation levels, symbolism, attack feasibility, and concerns for stakeholders. We argue that terrorists in general have comparatively few incentives to attack energy supply infrastructures based on our assessment of these factors. Moreover, higher levels of terrorist incidents in states more prone to internal violent conflict may suggest stronger incentives to attack energy infrastructures. When outlining energy security policies, the low frequency of worldwide attacks coupled with the high concentration of attacks in certain unstable countries should be taken into consideration. Energy importing countries could benefit from developing strategies to increase stability in key energy supply and/or transit countries facing risks of internal instability.