Silicon-on-Insulator-Based Retroreflective Optical Marker Chips for Simultaneous Identification and Localization

We demonstrate an omnidirectional, retroreflective optical marker in silicon on insulator that enables simultaneous identification and localization of objects. The most important chip requirement - its retroreflectivity - is realized by a large number of equally designed reflective ring resonator circuits, which operate at different angles of the incident light. The markers are characterized by an infrared camera that captures the response during flood exposure by a tunable infrared laser.     

Modeling and Experimental Verification of the Dynamic Interaction of an AFM-Tip With a Photonic Crystal Microcavity

We present a transmission model for estimating the effect of the atomic-force microscopy tapping tip height on a photonic crystal microcavity (MC). This model uses a fit of the measured tip-height-dependent transmission above a ldquohot spotrdquo in the MC. The predicted transmission versus average tapping height is in good agreement with the values obtained from tapping mode experiments. Furthermore, we show that for the existing, nonoptimized structure, the transmission coefficient can be tuned between 0.32 and 0.8 by varying the average tapping height from 26 to 265 nm. A transmission larger than that of the undisturbed cavity at resonance was observed at specific tip locations just outside the cavity-terminating holes.     

Cold Atmospheric Plasma Does Not Affect Stellate Cells Phenotype in Pancreatic Cancer Tissue in Ovo

Pancreatic ductal adenocarcinoma (PDAC) is a challenging neoplastic disease, mainly due to the development of resistance to radio- and chemotherapy. Cold atmospheric plasma (CAP) is an alternative technology that can eliminate cancer cells through oxidative damage, as shown in vitro, in ovo, and in vivo. However, how CAP affects the pancreatic stellate cells (PSCs), key players in the invasion and metastasis of PDAC, is poorly understood. This study aims to determine the effect of an anti-PDAC CAP treatment on PSCs tissue developed in ovo using mono- and co-cultures of RLT-PSC (PSCs) and Mia PaCa-2 cells (PDAC). We measured tissue reduction upon CAP treatment and mRNA expression of PSC activation markers and extracellular matrix (ECM) remodelling factors via qRT-PCR. Protein expression of selected markers was confirmed via immunohistochemistry. CAP inhibited growth in Mia PaCa-2 and co-cultured tissue, but its effectiveness was reduced in the latter, which correlates with reduced ki67 levels. CAP did not alter the mRNA expression of PSC activation and ECM remodelling markers. No changes in MMP2 and MMP9 expression were observed in RLT-PSCs, but small changes were observed in Mia PaCa-2 cells. Our findings support the ability of CAP to eliminate PDAC cells, without altering the PSCs.     

Radiation dose vs. image quality for low-dose CT protocols of the head for maxillofacial surgery and oral implant planning

The goal of this study was to determine the acquisition parameters for a low-dose multi-slice CT protocol and to compare the effective dose and the image quality of this low-dose protocol with the image quality of a clinical multi-slice CT protocol, routinely used for visualisation of the head. The low-dose protocol was derived from a clinical multi-slice CT protocol by lowering mA s and kV and increasing the pitch. The low-dose protocol yielded a dose reduction from 1.5 to 0.18 mSv for a multi-slice CT scan of the whole head, whereas noise in the low-dose CT images was increased. For bone segmentation, noise could be reduced by use of a non-linear edge preserving smoothing filter. Tests on ESP and skull phantom indicated that the accuracy of the measurements on low-dose CT is acceptable for image-based planning of maxillofacial and oral implant surgery, reducing the dose by a factor of 8.     

Experimental demonstration of high coupling efficiency between wide ridge waveguides and single-mode photonic Crystal waveguides

The experimental demonstration of a high efficiency coupling technique based on setting a single defect within a photonic crystal (PhC) taper is reported. The samples were fabricated on a Silicon-on-insulator substrate and a 3-/spl mu/m-wide ridge waveguide was used to couple the light into and out of a single-mode PhC waveguide. Transmission efficiencies higher than 70% for wavelengths at 1.55 /spl mu/m are demonstrated which sharply improves the transmission efficiency achieved with butt-coupling and conventional PhC tapers.     

The influence of Cr and Y on the micro structural evolution of Mg―Cr―O and Mg―Y―O thin films

The compositional influence of Cr and Y on the microstructure of Mg―Cr―O, and Mg―Y―O films synthesized by reactive magnetron sputtering has been investigated by transmission electron microscopy, X-ray diffraction and molecular dynamics simulations. A decrease in crystallinity is observed in these films as the M (Cr or Y) content is increased. It is found that M forms a solid solution with MgO for metal ratios up to ~ 70% and ~ 50% for Cr and Y respectively. Above ~ 70% Cr metal ratio the Mg―Cr―O films are found to be completely amorphous. The Mg―Y―O films are composed of Mg(Y)O and Y₂O₃ nano crystallites_, up to ~ 50% Y metal ratio. Above this ratio, only Y₂O₃ nano crystallites are found. The preferential < 111> MgO grain alignment is strongly affected by the increase in M content. For M metal ratios up to ~ 50%, there is a selective promotion of the < 100> MgO grain alignments and a decline in the < 111> grain alignments.     

Experience with a Virtual Memory Based Data Acquisition System at CERN

This paper describes a Data Acquisition System which has been specifically designed to take advantage of modern operating systems. It is modular, structured as a set of independent tasks communicating via a shared data area. The design is based on the concept of circular buffers with associated data producer and (parallel) consumer tasks. By using privileged tasks in time critical areas, a fast and efficient system has been obtained: interrupt latency of less than 100 microseconds, and data transfer speeds essentially limited by hardware (CAMAC DMA or magnetic tape recording). The tasks may be distributed over different processors. For example, 16/32 bit multi-processors with a shared multi-port memory are used to implement systems where powerful data reduction and/or monitoring tasks are required. The system is in use at over 25 high energy and nuclear physics experiments at CERN and in other European laboratories.     

Fabrication of photonic crystals in silicon-on-insulator using 248-nm deep UV lithography

We demonstrate wavelength-scale photonic nanostructures, including photonic crystals, fabricated in silicon-on-insulator using deep ultraviolet (UV) lithography. We discuss the mass-manufacturing capabilities of deep UV lithography compared to e-beam lithography. This is illustrated with experimental results. Finally, we present some of the issues that arise when trying to use established complementary metal-oxide-semiconductor processes for the fabrication of photonic integrated circuits.     

Plasma for cancer treatment: How can RONS penetrate through the cell membrane? Answers from computer modeling

Plasma is gaining increasing interest for cancer treatment, but the underlying mechanisms are not yet fully understood. Using computer simulations at the molecular level, we try to gain better insight in how plasma-generated reactive oxygen and nitrogen species (RONS) can penetrate through the cell membrane. Specifically, we compare the permeability of various (hydrophilic and hydrophobic) RONS across both oxidized and nonoxidized cell membranes. We also study pore formation, and how it is hampered by higher concentrations of cholesterol in the cell membrane, and we illustrate the much higher permeability of H2O2 through aquaporin channels. Both mechanisms may explain the selective cytotoxic effect of plasma towards cancer cells. Finally, we also discuss the synergistic effect of plasma-induced oxidation and electric fields towards pore formation.