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51.
Internet is offering a variety of services that are assembled to accomplish requests made by clients. While serving a request, security of the communications and of the data exchanged among services is crucial. Since communications occur along specific channels, it is equally important to guarantee that the interactions between a client and a server never get blocked because either cannot access a selected channel. We address here both these problems, from a formal point of view. A static analysis is presented, guaranteeing that a composition of a client and of possibly nested services respects both security policies for access control, and compliance between clients and servers. 相似文献
52.
In civil and mining operations that involve ground excavation and support, the loads are distributed between the ground and support depending on their relative stiffness. This paper presents the development of conceptual single-degree-of-freedom models, which are used to derive equations for estimating displacements and stresses for ground-support interaction problems encountered in pillars in room-andpillar mining(natural support system), and liners for circular vertical shafts(artificial support systems).For pillar assessment, mine-pillar interaction curves can be constructed using a double spring analogy.Additionally, the effectiveness of different support systems can be evaluated depending on their effect upon the mine-pillar system. For shaft design, an initial estimation of the required lining strength and thickness can be readily made based on a double ring analogue. For both problems, the results from the proposed approach compare well with those obtained by finite element numerical simulations. 相似文献
53.
Marcello BragliaAuthor Vitae Davide CastellanoMarco FrosoliniAuthor Vitae 《Computers in Industry》2014
The present paper provides the schema for an innovative and modular computer-based approach to the planning of activities in large-scale projects. Such projects are characterized by tens of thousands of tasks, which are consequently burdensome and difficult to plan manually. This is true to the point that in many shipyards only a low level of detail is used and poor planning is generally performed. The proposed approach is called computer-aided activity planning (CAAP), and an application in the yachting industry is shown to demonstrate its effectiveness. In particular, the so-called outfitting planning problem is faced. The CAAP system, taking into account the available shipyard resources and the knowledge on the building rules is able to automatically define, sequence, and schedule the activities of the whole outfitting process acting as a “planning configurator”. Moreover, it allows the industry-specific knowledge to be stored, maintained and shared within the (extended) organization. Owing to these “building blocks”, plans can be defined accurately and in a shorter time starting from pre-defined templates, with particular impact on lead times whenever variations to complex projects are needed. Finally, to verify the actual capabilities of the approach, the CAAP was implemented within a prototypical software called NautiCAAP. 相似文献
54.
Giuseppe Espa Danila Filipponi Diego Giuliani Davide Piacentino 《Papers in Regional Science》2014,93(Z1):S113-S135
In this paper, spatial shift‐share decomposition is analysed when applied to Italian data on regional business change at plant level, over the period 2004–2009. A new type of spatial decomposition, which looks more effectively at neighbourhood influence, is introduced here. Notable results emerge from the empirical investigation. First, it can be seen that the spatial level of aggregation greatly affects results. Second, evidence of neighbourhood advantage in the Southern NUTS 3 regions is found, together with opposite results for the Central‐Northern NUTS 3 regions. Finally, evidence of positive industrial mix effects is only found in Central‐Northern Italy. 相似文献
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Cristina Cornaro Simona Bartocci Davide Musella Cecilia Strati Alessandro Lanuti Simone Mastroianni Stefano Penna Andrea Guidobaldi Fabrizio Giordano Eleonora Petrolati Thomas M. Brown Andrea Reale Aldo Di Carlo 《Progress in Photovoltaics: Research and Applications》2015,23(2):215-225
New generation photovoltaic (PV) devices such as polymer and dye sensitized solar cells (DSC) have now reached a more mature stage of development, and among their various applications, building integrated PVs seems to have the most promising future, especially for DSC devices. This new generation technology has attracted an increasing interest because of its low cost due to the use of cheap printable materials and simple manufacturing techniques, easy production, and relatively high efficiency. As for the more consolidated PV technologies, DSCs need to be tested in real operating conditions and their performance compared with other PV technologies to put into evidence the real potential. This work presents the results of a 3 months outdoor monitoring activity performed on a DSC mini‐panel made by the Dyepower Consortium, positioned on a south oriented vertical plane together with a double junction amorphous silicon (a‐Si) device and a multi‐crystalline silicon (m‐Si) device at the ESTER station of the University of Rome Tor Vergata. Good performance of the DSC mini‐panel has been observed for this particular configuration, where the DSC energy production compares favorably with that of a‐Si and m‐Si especially at high solar angles of incidence confirming the suitability of this technology for the integration into building facades. This assumption is confirmed by the energy produced per nominal watt‐peak for the duration of the measurement campaign by the DSC that is 12% higher than that by a‐Si and only 3% lower than that by m‐Si for these operating conditions. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
58.
Giuseppe Floresta Chiara Zagni Davide Gentile Vincenzo Patamia Antonio Rescifina 《International journal of molecular sciences》2022,23(6)
The recent covid crisis has provided important lessons for academia and industry regarding digital reorganization. Among the fascinating lessons from these times is the huge potential of data analytics and artificial intelligence. The crisis exponentially accelerated the adoption of analytics and artificial intelligence, and this momentum is predicted to continue into the 2020s and beyond. Drug development is a costly and time-consuming business, and only a minority of approved drugs generate returns exceeding the research and development costs. As a result, there is a huge drive to make drug discovery cheaper and faster. With modern algorithms and hardware, it is not too surprising that the new technologies of artificial intelligence and other computational simulation tools can help drug developers. In only two years of covid research, many novel molecules have been designed/identified using artificial intelligence methods with astonishing results in terms of time and effectiveness. This paper reviews the most significant research on artificial intelligence in de novo drug design for COVID-19 pharmaceutical research. 相似文献
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Biagio Barone Luigi Napolitano Marco Abate Luigi Cirillo Pasquale Reccia Francesco Passaro Carmine Turco Simone Morra Francesco Mastrangelo Antonio Scarpato Ugo Amicuzi Vincenzo Morgera Lorenzo Romano Francesco Paolo Calace Savio Domenico Pandolfo Luigi De Luca Achille Aveta Enrico Sicignano Massimiliano Trivellato Gianluca Spena Carlo DAlterio Giovanni Maria Fusco Raffaele Vitale Davide Arcaniolo Felice Crocetto 《International journal of molecular sciences》2022,23(7)
Testosterone is the most important hormone in male health. Aging is characterized by testosterone deficiency due to decreasing testosterone levels associated with low testicular production, genetic factors, adiposity, and illness. Low testosterone levels in men are associated with sexual dysfunction (low sexual desire, erectile dysfunction), reduced skeletal muscle mass and strength, decreased bone mineral density, increased cardiovascular risk and alterations of the glycometabolic profile. Testosterone replacement therapy (TRT) shows several therapeutic effects while maintaining a good safety profile in hypogonadal men. TRT restores normal levels of serum testosterone in men, increasing libido and energy level and producing beneficial effects on bone density, strength and muscle as well as yielding cardioprotective effects. Nevertheless, TRT could be contraindicated in men with untreated prostate cancer, although poor findings are reported in the literature. In addition, different potential side effects, such as polycythemia, cardiac events and obstructive sleep apnea, should be monitored. The aim of our review is to provide an updated background regarding the pros and cons of TRT, evaluating its role and its clinical applicability in different domains. 相似文献