FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update and Novel Perspective

Irisin, the circulating peptide originating from fibronectin type III domain-containing protein 5 (FNDC5), is mainly expressed by muscle fibers under peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) control during exercise. In addition to several beneficial effects on health, physical activity positively affects nervous system functioning, particularly the hippocampus, resulting in amelioration of cognition impairments. Recently, FNDC5/irisin detection in hippocampal neurons and the presence of irisin in the cerebrospinal fluid opened a new intriguing chapter in irisin history. Interestingly, in the hippocampus of mice, exercise increases FNDC5 levels and upregulates brain-derived neurotrophic factor (BDNF) expression. BDNF, displaying neuroprotection and anti-inflammatory effects, is mainly produced by microglia and astrocytes. In this review, we discuss how these glial cells can morphologically and functionally switch during neuroinflammation by modulating the expression of a plethora of neuroprotective or neurotoxic factors. We also focus on studies investigating the irisin role in neurodegenerative diseases (ND). The emerging involvement of irisin as a mediator of the multiple positive effects of exercise on the brain needs further studies to better deepen this issue and the potential use in therapeutic approaches for neuroinflammation and ND.     

A lightweight and cost effective edge intelligence architecture based on containerization technology

World Wide Web - The integration of Cloud computing and Internet of Things led to rapid growth in the edge computing field. This would not be achievable without combining the data centers’...     

Design considerations for tunnel diode non-linear transmission lines

A tunnel diode non-linear transmission line has been investigated for second and third harmonic generation purposes. Design criteria are given and performance predictions have been obtained simulating the single diode behavior by means of a polynomial expression. An optimization of the non-linear transmission line as a harmonic generator has been obtained as a function of the number of diodes, their separation distances and the bias voltage.     

Oxidation of ethyl alcohol in trickle bed reactors: Analysis of the conversion rate

The interpretation of results of a chemical reaction carried out in a trickle bed reactor is not immediate when the key reactants are volatile; in fact some authors state that the overall conversion rate increases at very low liquid flow rates, i.e. when the catalyst is unevenly wetted. In these conditions, the reactants may penetrate inside the catalyst pellets directly through the “dry” zones; therefore the mass transfer resistance is diminished and the conversion rate can be increased. To investigate this phenomenon tests on the catalytic oxidation of ethyl alcohol dissolved in water were performed at different operating conditions in a trickle bed reactor. An interpretation of the results was tried by using two different models based on partially wetted particles. This approach considers both the cases in which “dry” zones are active or not for mass transfer and mass transfer rates are affected or not by the chemical reaction.     

Sufficient conditions for the stability of equilibrium for nonlinear conservative gyroscopic systems with first integrals

In this paper we find new first integrals of motion for a large class of nonlinear conservative gyroscopic mechanical systems. By means of the known first integrals, utilizing the classical Chetayev (1961) method, we construct a positive-definite first integral which ensures the stability of the equilibrium.     

Finite-Element Approach to the Erosion and Transport of Fine Particles in Granular Soils

The increase of the water table level presently occurring in the city of Milan led to some leakage of groundwater in underground facilities and subway tunnels. These structures, in fact, were completed about three decades ago when the water table was deeply located. To locally lower the ground water, and to eliminate or limit its flow towards the submerged openings, a series of pumping wells was placed in their vicinity. This provision, however, could lead to possible erosion of the fine fraction of the granular soil and to consequent settlements of nearby buildings. To investigate this phenomenon a finite-element approach has been developed for the analysis of the erosion and transport of the fine particles of granular soils subjected to a seepage flow. First, the continuity equation governing the problem and its finite-element formulation are discussed. Then, on the basis of the results of erosion tests presented in the literature, a law is derived that accounts for the nonlinear relationship between the total amount of eroded material, for time tending to infinity, and the velocity of seepage. Finally, this law is applied to the solution of one- and two-dimensional test examples, and some conclusions are drawn on the limits of the developed numerical model and on its possible improvement.     

ginSODA: massive parallel integration of stiff ODE systems on GPUs

The Journal of Supercomputing - Ordinary differential equations (ODEs) are a widespread formalism for the mathematical modeling of natural and engineering systems, whose analysis is generally...     

Software architectural patterns in practice: an empirical study

Software architecture involves a series of decisions based on many factors in a wide range of software development. Architects face recurring issues in different software architecture design, and to reduce huge cost and risks, software architecture decisions can rely on a set of idiomatic patterns commonly named architectural styles or patterns. Architectural pattern determines the vocabulary of components and connectors that are used in instances of the pattern together with a set of constraints to combine the two. Little contemporary data exists to document actual practices used by software professionals when selecting and incorporating architectural patterns for their projects in industry. Therefore, a comprehensive survey of software professionals was conducted to attempt to discover these practices. This exploratory survey and its quantitative results offer opportunities for further interpretation and comparison. Data from this survey are presented in this paper and include characteristics of projects, practices, organizations, and practitioners related to the usage of architectural patterns. Some of the notable findings include that architectural patterns are widely used in software projects with the Model–View–Controller being the most common. Despite reported difficulties in incorporating architectural patterns, the majority of the software professionals revealed that patterns were the most essential for completing the projects. The most difficult pattern to implement and the most expensive to adopt was the peer-to-peer, while the easiest was the client–server.