Normative data for the F(p) Scale of the MMPI–2: Implications for clinical and forensic assessment of malingering.

Data from several clinical samples and the Minnesota Multiphasic Personality Inventory–2 standardization group are presented to familiarize the reader with response patterns of different groups on a new validity scale designed to assist in the identification of exaggeration or fabrication of psychological disturbance. Sensitivity-specificity analyses are included along with suggestions for use of the F(p) Scale with other validity scales. Cautions about setting single cutoff scores are also discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Minnesota Multiphasic Personality Inventory normal K+ and other unelevated profiles.

Compared empirical correlates of normal K+ and non-K+ unelevated Minnesota Multiphasic Personality Inventory (MMPI) profiles in a psychiatric inpatient setting. Case history (symptom ratings, demographic variables, and diagnoses) and psychometric data were obtained without knowledge of MMPI profile group membership from psychiatrists' discharge summaries on 84 male and female inpatients. Normal K+ and non- K+ unelevated profile groups were more similar to each other than either group was to a randomly selected inpatient control group of 50 Ss. Results generally support the contention of M. D. Gynther and P. J. Brilliant (see record 1969-00131-001) that applicability of empirical correlates of unelevated MMPI profiles should be determined in each clinical setting. (6 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of nested polymerase chain reaction, virus isolation, and fluorescent antibody testing for identifying feline herpesvirus in cats with conjunctivitis

OBJECTIVE: To compare nested polymerase chain reaction (PCR), virus isolation (VI), and fluorescent antibody (FA) testing to detect feline herpesvirus (FHV) in cats with naturally acquired conjunctivitis or respiratory tract disease, or both. SAMPLES: Swab and microbrush specimens from the conjunctiva and throat were taken from 46 cats, allotted to 3 groups (conjunctivitis only, respiratory tract disease and conjunctivitis, and clinically normal). PROCEDURE: Cells from microbrush specimens were digested and herpesvirus DNA was amplified, using a double round of PCR. Products were detected by use of agarose gel electrophoresis. The VI and FA tests were performed in routine manner. RESULTS: Of 16 cats with conjunctivitis only, conjunctival specimens from 8 and throat specimens from 8 were FHV positive by PCR. None had positive results of VI or FA testing. Of 15 cats with respiratory tract disease and conjunctivitis, conjunctival specimens from 13 and throat specimens from 12 were FHV positive by PCR. A conjunctival specimen from 1 cat and throat specimens from 3 cats were FHV positive by VI. A conjunctival specimen from 1 cat was FHV positive by FA testing. Of 15 clinically normal cats, conjunctival and throat specimens from 2 cats were FHV positive by PCR; neither conjunctival nor throat specimens from these cats were FHV positive by VI or FA testing. CONCLUSION: For cats with respiratory tract disease and conjunctivitis, or with conjunctivitis only, nested PCR was more sensitive at detecting FHV than was VI or FA testing. CLINICAL RELEVANCE: Nested PCR is a more sensitive test than the currently available VI and FA tests for identifying FHV in cats with conjunctivitis.     

Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains

The epidermal growth factor receptor (EGFR) and p185c-neu proteins associate as dimers to create an efficient signaling assembly. Overexpression of these receptors together enhances their intrinsic kinase activity and concomitantly results in oncogenic cellular transformation. The ectodomain is able to stabilize the dimer, whereas the kinase domain mediates biological activity. Here we analyze potential interactions of the cytoplasmic kinase domains of the EGFR and p185c-neu tyrosine kinases by homology molecular modeling. This analysis indicates that kinase domains can associate as dimers and, based on intermolecular interaction calculations, that heterodimer formation is favored over homodimers. The study also predicts that the self-autophosphorylation sites located within the kinase domains are not likely to interfere with tyrosine kinase activity, but may regulate the selection of substrates, thereby modulating signal transduction. In addition, the models suggest that the kinase domains of EGFR and p185c-neu can undergo higher order aggregation such as the formation of tetramers. Formation of tetrameric complexes may explain some of the experimentally observed features of their ligand affinity and hetero-receptor internalization.     

Relationship between dishabituation, sensitization, and inhibition of the gill- and siphon-withdrawal reflex in Aplysia californica: Effects of response measure, test time, and training stimulus.

Previous studies have raised questions about the relationships between habituation, dishabituation, sensitization, and inhibition of reflex responses. To explore this issue further, a systematic study of these simple forms of learning was carried out in unrestrained Aplysia in which the amplitude as well as the duration of both the gill- and siphon-withdrawal reflexes were measured after either tailshock or mantle shock. The results suggest that transient reflex inhibition is not an invariant effect of noxious stimulation but depends instead on the response measure, test time, and type of noxious stimulus. Furthermore, the results suggest that dishabituation and sensitization may not involve different processes at the behavioral level; rather the observed differences between them may be due largely to an interaction between habituation and inhibition. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of psychopathology and demographic characteristics on MMPI-2 scale scores

Using multiple linear regression analyses, we examined the effects of subject status for 6 demographic variables and the presence of psychopathology on variance in MMPI-2 scale scores. The analyses were designed to measure the incremental contribution of the demographic variables to scale variance beyond that explained by presence of psychopathology. Demographic variables were found to contribute little incremental variance for the validity and clinical scales, but did explain more than 10% of the score variance for 1 clinical scale, 2 content scales, and 5 supplemental scales. For these 8 scales, gender was most often the potent demographic variable and an expected influence. The results are discussed in light of the use of gender-based norms and in terms of other potential factors that might explain MMPI-2 scale score variance.     

Boron diffusion and penetration in ultrathin oxide with poly-Sigate

Boron penetration through thin gate oxide down to 17 Å is investigated in this work. Boron penetration is characterized by the amount of flat band shift in a MOS capacitor. The effective diffusion coefficient of boron in these thin oxides is found to be higher than in thicker oxides. The introduction of a moderate dose of fluorine (1×10¹⁵ cm^-2) during gate doping enhances boron penetration in these thin oxides. Compared to as-deposited polycrystalline silicon (poly-Si), crystallized amorphous silicon (α-Si) films display slower boron diffusion in the gate and reduce enhancement of boron penetration due to fluorine. However, crystallized α-Si gate also reduces the amount of dopant activation and leads to extra gate depletion. The tradeoff between dopant activation and boron penetration is discussed