南波士顿海洋公园：21世纪公共空间设计

马萨诸塞港务局负责开发的南波土顿海洋公园是25万平方米闲置滨海区重新规划的核心工程之一。2004年开始运营的海洋主题公园不仅受到美国各界的广泛关注,而且荣获美国景观设计师协会颁发的国家荣誉奖。在哈文森设计事务所的带领下,景观设计师连同各学科人员共同创作出一个当代公共花园,它不仅立意鲜明大胆,而且生动地记录了该地区的百年海洋史。马萨诸塞港务局最初的目标是建设一座占地4500平方米的“主题公园”,     

School Trips: Effects of Urban Form and Distance on Travel Mode

For over 50 years the U.S. has been shifting away from small, neighborhood schools to larger schools in lower density areas. Rates of children walking and biking to school have declined significantly over this period. This study examines the relationship between urban form, distance, and middle school students walking and biking to and from four schools in Oregon. Five primary results emerge: (1) urban form helps predict travel mode to and from school; (2) middle school students walk further than planners expect; (3) many students use a different mode when they travel to school and when they leave school; (4) urban form measures that predict walking behavior differ from those that predict biking behavior; and (5) urban form is only one factor in students' transportation decisions.     

Multiple Risk Expert Systems Interventions: Impact of Simultaneous Stage-Matched Expert System Interventions for Smoking, High-Fat Diet, and Sun Exposure in a Population of Parents.

Three stage-based expert system interventions for smoking, high-fat diet, and unsafe sun exposure were evaluated in a sample of 2,460 parents of teenagers. Eighty-four percent of the eligible parents were enrolled in a 2-arm randomized control trial, with the treatment group receiving individualized feedback reports for each of their relevant behaviors at 0, 6, and 12 months as well as a multiple behavior manual. At 24 months, the expert system outperformed the comparison condition across all 3 risk behaviors, resulting in 22% of the participants in action or maintenance for smoking (vs. 16% for the comparison condition), 34% for diet (vs. 26%), and 30% for sun exposure (vs. 22%). Proactive, home-based, and stage-matched expert systems can produce significant multiple behavior changes in at-risk populations where the majority of participants are not prepared to change. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of metabolic alterations on the accumulation of technetium-99m-labeled d,l-HMPAO in slices of rat cerebral cortex

It is widely recognized that the distribution of technetium-99m-labeled d,l-hexamethylpropylene amine oxime (99mTc-HMPAO) in the brain is determined by the regional blood flow. However, other factors may affect this process including the metabolism of the brain tissue. To examine this possibility we studied the effects of metabolic alterations on 99mTc-HMPAO uptake in rat brain cortex slices, with concurrent measurement of oxygen consumption (QO2). 99mTc-HMPAO uptake was determined by incubating slices of rat cerebral cortex at 37 degrees C in Krebs-Ringer phosphate glucose medium containing 99mTc-HMPAO with and without test substances. Differential gradients for 99mTc activity between the tissue and the suspending medium (T/M ratio) were derived from the equation T/M[99mTc] = counts per gram of tissue/counts per milliliter of medium. The QO2 of the brain slices was measured using a biological oxygen monitor equipped with a polarographic oxygen probe. Inhibitors affecting oxidative phosphorylation caused parallel suppression of the T/M ratio and QO2. Agents that uncouple oxidation from phosphorylation increased the QO2 and decreased the T/M ratio. Incubation of slices at 22 degrees C depressed the T/M ratio and QO2. The presence of inhibitors of oxidative phosphorylation in the incubation medium increased the release of 99mTc activity from slices that had been prelabeled with 99mTc-HMPAO. These findings suggest that the altered metabolic status of the brain tissue modulates the kinetics and net accumulation of 99mTc-HMPAO at the cellular level by either depressing uptake, increasing back-diffusion, or both.     

Noninvasive assessment of cardiac diabetic neuropathy by carbon-11 hydroxyephedrine and positron emission tomography

OBJECTIVES: The purpose of this investigation was to evaluate the sympathetic nervous system of the heart by positron emission tomographic (PET) imaging in patients with diabetes mellitus with and without diabetic autonomic neuropathy. BACKGROUND: The clinical assessment of cardiac involvement in diabetic autonomic neuropathy has been limited to cardiovascular reflex testing. With the recent introduction of radiolabeled catecholamines such as carbon (C)-11 hydroxyephedrine, the sympathetic innervation of the heart can be specifically visualized with PET imaging. METHODS: Positron emission tomographic imaging was performed with C-11 hydroxyephedrine and rest myocardial blood flow imaging with nitrogen-13 ammonia. Three patient groups were studied, including healthy volunteers as control subjects, diabetic patients with normal autonomic function testing and diabetic patients with varying severity of autonomic neuropathy. Homogeneity of cardiac tracer retention as well as absolute tracer retention was determined by relating myocardial tracer retention to an arterial C-11 activity input function. RESULTS: Abnormal regional C-11 hydroxyephedrine retention was seen in seven of eight patients with autonomic neuropathy. Relative tracer retention was significantly reduced in apical, inferior and lateral segments. The extent of the abnormality correlated with the severity of conventional markers of autonomic dysfunction. Absolute myocardial tracer retention index measurements showed a 45 +/- 21% decrease in distal compared with proximal myocardial segments in autonomic neuropathy (0.069 +/- 0.037 min-1 vs. 0.13 +/- 0.052 min-1, p = 0.02). CONCLUSIONS: This study demonstrates a heterogeneous pattern of neuronal abnormalities in patients with diabetic cardiac neuropathy. The extent of this abnormality correlated with the severity of neuropathy assessed by conventional tests. Future studies in larger groups of patients are required to define the relative sensitivity of this imaging approach in detecting cardiac neuropathy and to determine the clinical significance of these scintigraphic findings in comparison with conventional markers of autonomic innervation.     

Implementation of a low-cost Interim 21CFR11 compliance solution for laboratory environments

In the recent past, compliance with 21CFR11 has become a major buzzword within the pharmaceutical and biotechnology industries. While commercial solutions exist, implementation and validation are expensive and cumbersome. Frequent implementation of new features via point releases further complicates purchasing decisions by making it difficult to weigh the risk of non-compliance against the costs of too frequent upgrades. This presentation discusses a low-cost interim solution to the problem. While this solution does not address 100% of the issues raised by 21CFR11, it does implement and validate: (1) computer system security; (2) backup and restore ability on the electronic records store; and (3) an automated audit trail mechanism that captures the date, time and user identification whenever electronic records are created, modified or deleted. When coupled with enhanced procedural controls, this solution provides an acceptable level of compliance at extremely low cost.     

Empirical evidence regarding relations among a model of epistemic and ontological cognition, academic performance, and educational level.

Models of personal epistemology have not been sufficiently integrated despite conceptual similarities. We attempted to model both dimensional and positional aspects of personal epistemology, as well as examine the domain specificity of these phenomena. The conceptual framework for this study was a new model of epistemic and ontological cognitive development that addresses numerous concerns in the literature. A model-based quantitative instrument was created and administered to 740 students ranging from middle-school through graduate school. Results of confirmatory factor and factor-mixture model analyses provided evidence for the construct validity and reliability of scores from the instrument as well as support for many aspects of the underlying conceptual model. Implications for further model development and research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The importance of advancing technology to America’s energy goals

A wide range of energy technologies appears to be needed for the United States to meet its energy goals. A method is developed that relates the uncertainty of technological progress in eleven technology areas to the achievement of CO₂ mitigation and reduced oil dependence. We conclude that to be confident of meeting both energy goals, each technology area must have a much better than 50/50 probability of success, that carbon capture and sequestration, biomass, battery electric or fuel cell vehicles, advanced fossil liquids, and energy efficiency technologies for buildings appear to be almost essential, and that the success of each one of the 11 technologies is important. These inferences are robust to moderate variations in assumptions.