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691.
CH Greene 《Canadian Metallurgical Quarterly》1985,32(3):1880-1882
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The possible modulatory role of microtubules or closely related colchicine-sensitive structures in the response of human lymphocytes to mitogenic lectins was investigated. Colchicine (0.1 to 10 muM) AND VINBLASTINE (0.1 TO 10 MUM) inhibited early [14C]-aminoisobutyric acid and late [3H]-thymidine uptake in phytohemagglutinin-and concanavalin A-stimulated human lymphocytes but failed to alter 45Ca uptake. Lumicolchicine, an inactive congener of colchicine, was ineffective in all three systems. Both microtubular agents accentuated and prolonged the early cyclic AMP response to lectin. Little or no alteration in cyclic AMP levels was seen with colchicine or vinblastine alone or in combination with PGE (10MUM) or epinephrine (1muM) suggesting that the effect on cyclic AMP metabolism is largely selective for lectin stimulation. Neither microtunular agent altered 125I-concanacalin A binding. Since the inhibition of DNA synthesis was throughout the culture period and early aminoisobutyric acid uptake is affected, it appears that these agents are acting on an early event, or events, in the activation sequence. Although the mechanism of the inhibition is not known, the effect of colchicine and vinblastine in prolonging the cyclic AMP response to lectin may be involved. Alternatively, alterations in microtubules assembly may exert effects on membrane architecture interfering with propagation of the stimulus from the membrane to the cell interior. 相似文献
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Langner Thomas S.; Gersten Joanne C.; Greene Edward L.; Eisenberg Jeanne G.; Herson Joseph H.; McCarthy Elizabeth D. 《Canadian Metallurgical Quarterly》1974,42(2):170
Reports on the prevalence of, treatment for, and factors associated with treatment for serious psychological impairment in urban children aged 6-18. 2 Manhattan samples were studied, the 1st a random cross-section of 1,034 families and the 2nd of 1,000 families receiving welfare (Aid to Dependent Children). A significantly greater number of welfare children were seriously impaired, but the referral rate and long-term treatment rate of children in the 2 samples were similar. Less than 50% of the seriously impaired children were referred, and only 1 in 5 received treatment of 6 mo or longer. Referral rates increased dramatically as mother's education increased, whether she did or did not receive welfare. Families who referred their children were colder, less punitive, and of higher social status. Implications of the findings and possible solutions of the imbalance between treatment and need are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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The stochastic control of the F-8C aircraft using a multiple model adaptive control (MMAC) method--Part I: Equilibrium flight 总被引:1,自引:0,他引:1
Athans M. Castanon D. Dunn K. Greene C. Wing Lee Sandell N. Jr. Willsky A. 《Automatic Control, IEEE Transactions on》1977,22(5):768-780
The purpose of this paper is to summarize some results obtained for the adaptive control of the F-8C aircraft using the so-called MMAC method. The discussion includes the selection of the performance criteria for both the lateral and the longitudinal dynamics, the design of the Kalman filters for different flight conditions, the "identification" aspects of the design using hypothesis testing ideas, and the performance of the closed-loop adaptive system. 相似文献
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