Modular Ligation of Thioamide Functional Peptides onto Solid Cellulose Substrates

Hetero Diels‐Alder (HDA) cycloaddition – as an effective modular conjugation approach – is employed to graft thioamide endfunctional oligopeptides onto solid cyclopentadienyl (Cp) functional cellulose substrates generating cellulose‐peptide hybrid materials. The highly reactive Cp moieties serve as diene functionality in the consecutive HDA reaction on the biosubstrate surface. Oligopeptides (i.e., the model peptide Gly‐Gly‐Arg‐Phe‐Pro‐Trp‐Trp‐Gly and the antimicrobial peptide tritrpticin) are functionalized at their N‐termini employing strongly electron deficient thiocarbonyl thio compounds resulting in biomacromolecules bearing a thioamide endgroup. The dienophile‐ functional peptides readily undergo HDA reactions at ambient temperature and under mild conditions in solution with synthetic polymers as well as on solid (bio)substrates. An in‐depth investigation is provided of the influence of the temperature, the Lewis acid catalysis and the side group exchange of thioamide functional oligopeptides reacting with Cp terminated poly(methyl methacrylate) (M_n = 2100 g·mol^?1, PDI = 1.1) in homogenous solution as well as Cp functionalized cellulose in a heterogeneous system. To assess the success of the grafting reaction, the soluble samples were subjected to characterization methods such as size exclusion chromatography (SEC) and SEC‐electrospray ionization mass spectrometry (SEC‐ESI‐MS). The heterogeneous “grafting‐to” reactions were monitored using high resolution attenuated total reflection (ATR) Fourier transform infrared microscopy (HR‐FTIRM) imaging, X‐ray photoelectron spectroscopy (XPS) and elemental analysis. Evaluation via elemental analysis leads to quantitative peptide cellulose surface loading capacities.     

Integration of InGaP/GaAs/Ge triple‐junction solar cells on deeply patterned silicon substrates

We report preliminary results on InGaP/InGaAs/Ge photovoltaic cells for concentrated terrestrial applications, monolithically integrated on engineered Si(001) substrates. Cells deposited on planar Ge/Si(001) epilayers, grown by plasma‐enhanced chemical vapor deposition, provide good efficiency and spectral response, despite the small thickness of the Ge epilayers and a threading dislocation density as large as 10⁷/cm². The presence of microcracks generated by the thermal misfit is compensated by a dense collection grid that avoids insulated areas. In order to avoid the excessive shadowing introduced by the use of a dense grid, the crack density needs to be lowered. Here, we show that deep patterning of the Si substrate in blocks can be an option, provided that a continuous Ge layer is formed at the top, and it is suitably planarized before the metalorganic chemical vapor deposition. The crack density is effectively decreased, despite that the efficiency is also lowered with respect to unpatterned devices. The reasons of this efficiency reduction are discussed, and a strategy for improvement is proposed and explored. Full morphological analysis of the coalesced Ge blocks is reported, and the final devices are tested under concentrated AM1.5D spectrum. Copyright © 2016 John Wiley & Sons, Ltd.     

平台2015:Intel处理器及平台在下一个十年的演化

毫无疑问,近年来计算技术取得了长足的进步。但是,在未来的十年,主流计算技术中新的工作量、使用模式的出现及变化对未来的计算平台提出的要求,与过去十年所取得的进展也差不多,这些巨大的要求包括:更高的性能、更低的功率密度、更好的功能可扩展性。倘若出现这些使用计算机的震撼性的变化,我们怎样定义和构架未来的计算平台,就将不得不做出引人注目的改变。要整体地理解和满足的,不仅仅有计算的需要,而且还有接口以及系统基础设施的需要。Intel对这三个基础平台要素的演化的长期设想,以及驱动演化的架构的创新和核心能力,即是我们称之为平台2015(Platform2015)的内容。除了考察相关的趋势、使用、平台处理含意之外,本文将集中在平台2015的计算单元,描述Intel微处理器架构在未来十年的演化。     

Anodization for Simplified Processing and Efficient Charge Transport in Vertical Organic Field‐Effect Transistors

Vertical organic transistors are an attractive alternative to realize short channel transistors, which are required for powerful electronic devices and flexible electronic circuits operating at high frequencies. Unfortunately, the vertical device architecture comes along with an increased device fabrication complexity, limiting the potential of this technology for application. A new design of vertical organic field‐effect transistors (VOFETs) with superior electrical performance and simplified processing is reported. By using electrochemical oxidized aluminum oxide (AlO_x) as a pseudo self‐aligned charge‐blocking structure in vertical organic transistors, direct leakage current between the source and drain can be effectively suppressed, enabling VOFETs with very low off‐current levels despite the short channel length. The anodization technique is easy to apply and can be surprisingly used on both n‐type and p‐type organic semiconductor thin films with significant signs of degradation. Hence, the anodization technique enables a simplified process of high‐performance p‐type and n‐type VOFETs, paving the road toward complementary circuits made of vertical transistors.     

Plastic deformation kinetics of electrodeposited Cu foil at low and intermediate homologous temperatures

The plastic deformation kinetics of electrodeposited (EP) Cu foil (grain size d=0.6 μm) were determined at 296–448 K and compared with those for vapor-deposited (VP) foil (d=0.5 μm) tested at 77–473 K. The apparent activation volume v=kT ∂ ln for both materials exhibited a minimum at ∼350 K, and at this temperature, there occurred a marked increase in the temperature dependence of the flow stress σ. The rate-controlling mechanism in both materials at T<373 K appears to be grain boundary shear induced by dislocation pileups at the grain boundaries. The results at T=373–473 K suggest that the dislocation pileups are relieved or prevented and that either cross slip or intersection of dislocations is rate controlling with stronger support for the latter. The determination of the rate-controlling mechanism at the higher temperatures is complicated by possible changes in defect structure due to thermal annealing, and therefore, the operative mechanism corresponds to a structure that may differ from the initial, as-deposited condition.     

Realization of an active inductance for a low power high bandwidth DC power line communication network transceiver

An active inductor based on an improved gyrator circuit is proposed. The active inductor is developed to be implemented in a high impedance transceiver for a wearable DC power line communication network where requirements such as low power consumption, high bandwidth and numerous nodes support are prioritized. A load isolation step is introduced to ensure the stability of the active inductance's size on different load currents. The proposed gyrator circuit is analyzed and optimized by means of theoretical calculations. The theoretical results are then verified by simulations and experiments in the frequency range up to 10 MHz.     

Suitability of four blackcurrant cultivars for industrial syrup production

The four blackcurrant cultivars Øjebyn, Ben Nevis, Ben Lomond and Silvergieter have been evaluated with reference to their suitability for syrup production. The examination was based on sensory and physico-chemical characterisation, and was performed on the berries themselves and the syrup. The results show that Øjebyn is less suitable for syrup production, while Ben Nevis and Ben Lomond differ insignificantly in most qualities from the reference cultivar, Silvergieter. Criteria for the evaluation of cultivars for industrial suitability are discussed.     

Analysis of a 26 756 bp segment from the left arm of yeast chromosome IV

The nucleotide sequence of a 26·7 kb DNA segment from the left arm of Saccharomyces cerevisiae chromosome IV is presented. An analysis of this segment revealed 11 open reading frames (ORFs) longer than 300 bp and one split gene. These ORFs include the genes encoding the large subunit of RNA polymerase II, the biotin apo-protein ligase, an ADP-ribosylation factor (ARF 2), the ‘L35’-ribosomal protein, a rho GDP dissociation factor, and the sequence encoding the protein phosphatase 2A. Further sequence analysis revealed a short ORF encoding the ribosomal protein YL41B, an intron in a 5′ untranslated region and an extended homology with another cosmid (X83276) located on the same chromosome. The potential biological relevance of these findings is discussed. The sequence was submitted to the EMBL database under Accession Number X96876.     

Mirror or Molder? A Study of Media Coverage,Stock Prices,and Trading Volumes in Germany

This article investigates the short‐term relationship between media coverage, stock prices, and trading volumes of eight listed German companies. A content analysis of news reports about the selected companies and a secondary analysis of the daily changes in closing prices and the trading volumes of these companies were combined in a time‐series design. After ARIMA‐modeling each of them, the results suggest that media coverage rather reflects than shapes the development at stock exchanges from a short‐term perspective (2 months). There were almost no hints for a widespread media effect, that is, an impact on so many investors that it will result in a measurable change in stock prices or trading volumes. Finally, theoretical and methodological consequences for exploring widespread media effects are discussed.