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排序方式: 共有145条查询结果,搜索用时 46 毫秒
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Toya Okawa Kurumi Hara Momoko Goto Moe Kikuchi Masataka Kogane Hiroto Hatakeyama Hiroki Tanaka Daiki Shirane Hidetaka Akita Akihiro Hisaka Hiromi Sato 《International journal of molecular sciences》2021,22(16)
The second messenger 2′3′-cyclic-GMP-AMP (cGAMP) is thought to be transmitted from brain carcinomas to astrocytes via gap junctions, which functions to promote metastasis in the brain parenchyma. In the current study, we established a method to introduce cGAMP into astrocytes, which simulates the state of astrocytes that have been invaded by cGAMP around tumors. Astrocytes incorporating cGAMP were analyzed by metabolomics, which demonstrated that cGAMP increased glutamate production and astrocyte secretion. The same trend was observed for γ-aminobutyric acid (GABA). Conversely, glutamine production and secretion were decreased by cGAMP treatment. Due to the fundamental role of astrocytes in regulation of the glutamine–glutamate cycle, such metabolic changes may represent a potential mechanism and therapeutic target for alteration of the central nervous system (CNS) environment and the malignant transformation of brain carcinomas. 相似文献
74.
Hair lipid images, as visualized by argon sputter etching-scanning electron microscopy (ASE-SEM), reveal convex structures
with a stitch pattern (SP) at the cell membrane complex (CMC) in the transverse hair plane. Based on interindividual variation,
different features of the convex SP were classified into Types 0 to 4 with the corresponding scores 0 to 4. Observations using
hair fibers collected from 27 Japanese females revealed significant positive correlations between the scores and the levels
of exogenous lipids, which suggests that exogenous lipids internalized at the CMC predominantly constitute the convex SP.
Intraindividual variation with different levels of exogenous lipids among hair fibers derived from individual females may
be relevant to the uneven physicochemical properties of hair fibers on the scalp. Observations of 380 hair fibers collected
from Japanese (Mongoloid), German and American (Caucasoid) females aged 3 to 77 yr demonstrated similar age-related changes
in the lipid images, which represent an increase and then a decrease in levels of exogenous lipids with increasing age. This
suggests that age-related changes in exogenous lipids are attributable to alterations in sebum excreted during aging and that
this elicits age-related changes in physical parameters, which affect human hair texture. 相似文献
75.
Third-harmonic generation (THG) in air in tight-focusing conditions is presented. Variation of the pulse duration supplied optimal conditions for THG by femtosecond pulses that varied in the range 110-1300 fs. We show that this third-harmonic generation was caused by Kerr-induced phase variations of fundamental and harmonic beams. Various characteristics (laser intensity, focusing conditions, pulse duration, air pressure, etc.) of THG in air were analyzed to optimize this process. The THG conversion efficiency of 795 nm, 300 fs radiation was 1 x 10(-3). The harmonic radiation did not show considerable disruption of its spectral and spatial distribution in tight focusing conditions for intensities as high as 5 x 10(14) W cm(-2). 相似文献
76.
Nakanishi T Kozai H Morita M Murakami H Sagara T Ariga K Nakashima N 《Journal of nanoscience and nanotechnology》2006,6(6):1779-1785
Studies of the electrochemistry of Langmuir-Blodgett (LB) films of C70/artificial lipids including tridodecylmethylammonium bromide (3C12N+Br-, 1), didodecylphosphate (2C12PO4H, 2), and dioleoylphosphatidylcholine (DOPC, 3) and of LB films of a fullerene lipid (4) bearing triple alkyl chains on a C60 moiety on electrodes were carried out in aqueous media. Stable Langmuir monolayers of fullerene C70/artificial lipid composites and the fullerene lipid (4) were formed at the air-water interface and these monolayers were transferred onto electrodes as LB films. Here, we focus on the importance of cationic matrix lipid films to the facile electrochemistry of C70 embedded in a LB film of cationic lipids on an electrode in aqueous media. On the basis of the electrolyte dependence and the charge dependence of the matrix lipids, a possible electron-transfer mechanism of the C70/artificial lipid LB film-modified electrodes is presented. Electrochemistry of a LB film of 4 was also obtained in an aqueous medium. We demonstrate that the introduction of the chemistry of lipid bilayer membranes to the LB films of fullerenes guides us toward the construction of fullerene/lipid bilayer devices. 相似文献
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78.
Yoshihide Fujisaki Hiroto Sato Toshihiro Yamamoto Hideo Fujikake Shizuo Tokito Taiichiro Kurita 《Journal of the Society for Information Display》2007,15(7):501-506
Abstract— A flexible color LCD panel driven by organic TFTs (OTFTs) was successfully demonstrated. A pentacene OTFT with an anodized Ta2O5 gate insulator, which can be operated at low voltage, was developed. In order to improve the electrical performance of the OTFT, the gate insulator was surface treated by processes such as O2 plasma, UV light irradiation, and hexamethyldisilane treatments. The fabricated OTFT exhibited a mobility of 0.3 cm2/V‐sec and a current on/off ratio of 107 with a low operating drain voltage of ?5 V. A fast‐response‐time flexible ferroelectric LCD, which contains polymer networks and walls, was integrated with the OTFTs by using a lamination and a printing technique. As a result, color images were achieved on the fabricated panel by using a field‐sequential‐color method at a low driving voltage of less than 15 Vpp. 相似文献
79.
Seiji Kanazawa Hiroto Tanaka Toshikazu Ohkubo Marek Kocik Jen-Shih Chang 《Thin solid films》2007,515(9):4266-4271
In this study, the LIF detection of the hydroxyl (OH) radicals was performed in a nozzle-to-plane electrode system having an electrode gap of 30 mm during the steady-state positive streamer corona discharge at atmospheric pressure. For monitoring the ground-state OH radicals, OH transition [A2 Σ+(v′ = 1) ← X2Π(v″ = 0)] at 282 nm was used. The time relationship between the regular streamer coronas, laser pulse, OH fluorescence and laser-induced streamer was measured. The time dependence of OH radicals between the successive streamers was measured for the evaluation of OH dynamics when the discharge was in a steady-state condition. The two-dimensional OH distribution in the DC streamer corona discharge was observed. The obtained results showed that the ground-state OH radicals were generated mainly in the filamentary part of the streamers. It was found that LIF detectable amount of ground-state OH radicals stayed in the region where streamers propagate during the steady-state DC positive streamer corona in open air. 相似文献