A High-Speed Optical Data Highway for Industrial Control Systems

Recent application of distributed control systems to large-and medium-scale industrial plants requires effective and high-speed communication among the control devices each other to ensure high-performance operation.     

Adjunctive Application of Antimicrobial Photodynamic Therapy in Nonsurgical Periodontal Treatment: A Review of Literature

Periodontal disease is caused by dental plaque biofilms, and the removal of these biofilms from the root surface of teeth plays a central part in its treatment. The conventional treatment for periodontal disease fails to remove periodontal infection in a subset of cases, such as those with complicated root morphology. Adjunctive antimicrobial photodynamic therapy (aPDT) has been proposed as an additional treatment for this infectious disease. Many periodontal pathogenic bacteria are susceptible to low-power lasers in the presence of dyes, such as methylene blue, toluidine blue O, malachite green, and indocyanine green. aPDT uses these light-activated photosensitizer that is incorporated selectively by bacteria and absorbs a low-power laser/light with an appropriate wavelength to induce singlet oxygen and free radicals, which are toxic to bacteria. While this technique has been evaluated by many clinical studies, some systematic reviews and meta-analyses have reported controversial results about the benefits of aPDT for periodontal treatment. In the light of these previous reports, the aim of this review is to provide comprehensive information about aPDT and help extend knowledge of advanced laser therapy.     

The pumping performances of the turbomoleculae pump simulated by direct simulation monte carlo method

Turbomolecular pumps (TMPs) are used extensively in several highly important areas of industry and research. The performances of TMP are evaluated by maximum throughput and maximum pressure ratio. In this paper, they are investigated by DSMC method. A 3D analysis in a rotating reference frame is proposed to simulate this flow field. Considering the Coriolis and centrifugal accelerations, the equations about the molecular velocities and position are deduced. The VSS model and NTC collision schemes are used to calculate the intermolecular collisions. The diffuse reflection is employed on the molecular reflection from the surfaces of boundary. The procedures for establishment of the correct collision rate are based on the cells, while individual collision pairs are chosen from the sub-cells. The pump performances of one stage TMP under the different kinds of gas, different heights, and different blade angles are simulated and the results are analyzed. Numerical results agree well with the existing experiment data.     

Analysis of Cs-adsorption behavior using a column filled with microcapsule beads of potassium copper hexacyanoferrate

Ash-washing technology is a crucially important technology for removing radioactive Cs from contaminated ash. For that technology, Cs⁺ removal from the ash-washing solution by the adsorbent is necessary. This study was conducted to establish rapid preparation of appropriate adsorption columns for Cs⁺ uptake. A one-site model was not used for analysis because the model cannot accommodate sites with different adsorption speed. Results demonstrated that the adsorption behavior of the column filled with the granules of potassium copper hexacyanoferrate was well reproduced by a two-site adsorption model with parameters chosen through analysis of batch adsorption test results.     

Sensitivity analysis of fuel pin failure performance under slow-ramp type transient overpower condition by using a fuel performance analysis code FEMAXI-FBR

The FEMAXI-FBR is a fuel performance analysis code and has been developed as one module of core disruptive evaluation system, the ASTERIA-FBR. The FEMAXI-FBR has reproduced the failure pin behavior during slow transient overpower. The axial location of pin failure affects the power and reactivity behavior during core disruptive accident, and failure model of which pin failure occurs at upper part of pin is used by reflecting the results of the CABRI-2 test. By using the FEMAXI-FBR, sensitivity analysis of uncertainty of design parameters such as irradiation conditions and fuel fabrication tolerances was performed to clarify the effect on axial location of pin failure during slow transient overpower. The sensitivity analysis showed that the uncertainty of design parameters does not affect the failure location. It suggests that the failure model with which locations of failure occur at upper part of pin can be adopted for core disruptive calculation by taking into consideration of design uncertainties.     

Triple‐junction effect and its electric field relaxation in three dielectrics

This paper analyzes the electric field distribution near a wedge‐like edge in arrangements consisting of three dielectrics using analytical and numerical methods. The electric potential behaves exponentially as rⁿ (r is the distance from the edge) near the edge, leading to an infinitely high field with decreasing r for all cases. The value of the analytically derived exponent n agreed well with that obtained from the numerical field calculations. It has also been demonstrated that rounded contact of the spacer with a zero contact angle can make the electric field constant without showing an exponential rise near the edge. © 2009 Wiley Periodicals, Inc. Electr Eng Jpn, 167(1): 1– 8, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20670     

State-of-the-Art Molecular Dynamics Simulation Studies of RNA-Dependent RNA Polymerase of SARS-CoV-2

Molecular dynamics (MD) simulations are powerful theoretical methods that can reveal biomolecular properties, such as structure, fluctuations, and ligand binding, at the level of atomic detail. In this review article, recent MD simulation studies on these biomolecular properties of the RNA-dependent RNA polymerase (RdRp), which is a multidomain protein, of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are presented. Although the tertiary structures of RdRps in SARS-CoV-2 and SARS-CoV are almost identical, the RNA synthesis activity of RdRp of SARS-CoV is higher than SARS-CoV-2. Recent MD simulations observed a difference in the dynamic properties of the two RdRps, which may cause activity differences. RdRp is also a drug target for Coronavirus disease 2019 (COVID-19). Nucleotide analogs, such as remdesivir and favipiravir, are considered to be taken up by RdRp and inhibit RNA replication. Recent MD simulations revealed the recognition mechanism of RdRp for these drug molecules and adenosine triphosphate (ATP). The ligand-recognition ability of RdRp decreases in the order of remdesivir, favipiravir, and ATP. As a typical recognition process, it was found that several lysine residues of RdRp transfer these ligand molecules to the binding site such as a “bucket brigade.” This finding will contribute to understanding the mechanism of the efficient ligand recognition by RdRp. In addition, various simulation studies on the complexes of SARS-CoV-2 RdRp with several nucleotide analogs are reviewed, and the molecular mechanisms by which these compounds inhibit the function of RdRp are discussed. The simulation studies presented in this review will provide useful insights into how nucleotide analogs are recognized by RdRp and inhibit the RNA replication.