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61.
Front Cover: Photoactivatable Mussel‐Based Underwater Adhesive Proteins by an Expanded Genetic Code (ChemBioChem 18/2017) 下载免费PDF全文
Dr. Matthias Hauf Dr. Florian Richter Tobias Schneider Thomas Faidt Dr. Berta M. Martins Dr. Tobias Baumann Dr. Patrick Durkin Prof. Dr. Holger Dobbek Prof. Dr. Karin Jacobs Prof. Dr. Andreas Möglich Prof. Dr. Nediljko Budisa 《Chembiochem : a European journal of chemical biology》2017,18(18):1771-1771
62.
This article develops methods to estimate the tail and full distribution of the lengths of the 0-intervals in a continuous time stationary ergodic stochastic process that takes the values 0 and 1 in alternating intervals. The setting is that each of many such 0–1 processes has been observed during a short time window. Thus, the observed 0-intervals could be noncensored, right-censored, left-censored, or doubly-censored, and the lengths of 0-intervals that are ongoing at the beginning of the observation window have a length-biased distribution. We exhibit parametric conditional maximum likelihood estimators for the full distribution, develop maximum likelihood tail estimation methods based on a semiparametric generalized Pareto model, and propose goodness-of-fit plots. Finite sample properties are studied by simulation, and asymptotic normality is established for the most important case. The methods are applied to estimation of the length of off-road glances in the 100-car study, a big naturalistic driving experiment. Supplementary materials that include MatLab code for the estimation routines and a simulation study are available online. 相似文献
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64.
Marin Lujak Holger Billhardt Sascha Ossowski 《Annals of Mathematics and Artificial Intelligence》2016,78(1):73-100
In this paper we study the coordination of Emergency Medical Service (EMS) for patients with acute myocardial infarction with ST-segment elevation (STEMI). This is a health problem with high associated mortality. A “golden standard” treatment for STEMI is angioplasty, which requires a catheterization lab and a highly qualified cardiology team. It should be performed as soon as possible since the delay to treatment worsens the patient’s prognosis. The decrease of the delay is achieved by coordination of EMS, which is especially important in the case of multiple simultaneous patients. Nowadays, this process is based on the First-Come-First-Served (FCFS) principle and it heavily depends on human control and phone communication with high proneness to human error and delays. The objective is, therefore, to automate the EMS coordination while minimizing the time from symptom onset to reperfusion and thus to lower the mortality and morbidity resulting from this disease. In this paper, we present a multi-agent decision-support system for the distributed coordination of EMS focusing on urgent out-of-hospital STEMI patients awaiting angioplasty. The system is also applicable to emergency patients of any pathology needing pre-hospital acute medical care and urgent hospital treatment. The assignment of patients to ambulances and angioplasty-enabled hospitals with cardiology teams is performed via a three-level optimization model. At each level, we find a globally efficient solution by a modification of the distributed relaxation method for the assignment problem called the auction algorithm. The efficiency of the proposed model is demonstrated by simulation experiments. 相似文献
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Dr. Holger Siebeneicher Dr. Arwed Cleve Dr. Hartmut Rehwinkel Dr. Roland Neuhaus Dr. Iring Heisler Dr. Thomas Müller Dr. Marcus Bauser Dr. Bernd Buchmann 《ChemMedChem》2016,11(20):2261-2271
Despite the long‐known fact that the facilitative glucose transporter GLUT1 is one of the key players safeguarding the increase in glucose consumption of many tumor entities even under conditions of normal oxygen supply (known as the Warburg effect), only few endeavors have been undertaken to find a GLUT1‐selective small‐molecule inhibitor. Because other transporters of the GLUT1 family are involved in crucial processes, these transporters should not be addressed by such an inhibitor. A high‐throughput screen against a library of ~3 million compounds was performed to find a small molecule with this challenging potency and selectivity profile. The N‐(1H‐pyrazol‐4‐yl)quinoline‐4‐carboxamides were identified as an excellent starting point for further compound optimization. After extensive structure–activity relationship explorations, single‐digit nanomolar inhibitors with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4 were obtained. The most promising compound, BAY‐876 [N4‐[1‐(4‐cyanobenzyl)‐5‐methyl‐3‐(trifluoromethyl)‐1H‐pyrazol‐4‐yl]‐7‐fluoroquinoline‐2,4‐dicarboxamide], showed good metabolic stability in vitro and high oral bioavailability in vivo. 相似文献
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68.
Volkan Kumtepeli Yulong Zhao Maik Naumann Anshuman Tripathi Youyi Wang Andreas Jossen Holger Hesse 《国际能源研究杂志》2019,43(9):4127-4147
The rapid increase of renewable energy sources made coordinated control of the distributed and intermittent generation units a more demanded task. Matching demand and supply is particularly challenging in islanded microgrids. In this study, we have demonstrated a mixed‐integer quadratic programming (MIQP) method to achieve efficient use of sources within an islanded microgrid. A unique objective function involving fuel consumption of diesel generator, degradation in a lithium‐ion battery energy storage system, carbon emissions, load shifting, and curtailment of the renewable sources is constructed, and an optimal operating point is pursued using the MIQP approach. A systematic and extensive methodology for building the objective function is given in a sequential and explicit manner with an emphasis on a novel model‐based battery aging formulation. Performance of the designed system and a sensitivity analysis of resulting battery dispatch, diesel generator usage, and storage aging against a range of optimization parameters are presented by considering real‐world specifications of the Semakau Island, an island in the vicinity of Singapore. 相似文献
69.
In this paper, we are exploring the approach to utilize system-specific static analyses of code with the goal to improve software
quality for specific software systems. Specialized analyses, tailored for a particular system, make it possible to take advantage
of system/domain knowledge that is not available to more generic analyses. Furthermore, analyses can be selected and/or developed
in order to best meet the challenges and specific issues of the system at hand. As a result, such analyses can be used as
a complement to more generic code analysis tools because they are likely to have a better impact on (business) concerns such
as improving certain software quality attributes and reducing certain classes of failures. We present a case study of a large,
industrial embedded system, giving examples of what kinds of analyses could be realized and demonstrate the feasibility of
implementing such analyses. We synthesize lessons learned based on our case study and provide recommendations on how to realize
system-specific analyses and how to get them adopted by industry. 相似文献
70.
Christoph Wagner Christine Wenzl Dean Gregurek Daniel Kreuzer Stefan Luidold Holger Schnideritsch 《Metallurgical and Materials Transactions B》2017,48(1):119-131
Corrosion mechanisms between MgO refractory substrates and FeNi slags were investigated. The FeNi slags taken into consideration represent a simple synthetically mixed slag with specific oxides and a real slag from a ferroalloy producer. The MgO refractory substrates with the specimens of FeNi slag were heated in a hot-stage microscope at 10 K/min from room temperature to three different temperatures 1573 K, 1723 K, and 1923 K (1300 °C, 1450 °C, and 1650 °C). The experiments were carried out under a controlled gas atmosphere that simulates the relevant process conditions. The corrosion mechanisms of each system were followed by scanning electron microscope analyses. The results obtained showed that slag corrosion dominates, with a pronounced partial dissolution of refractory fines forming Mg-silicates of type forsterite. It was also observed that iron oxide present in the slag diffused into the coarse refractory grains forming magnesiowustite. Finally, the results obtained were compared with those predicted by FACTSAGE software to understand the corrosion mechanisms and draw implications for improving the refractory performance and lifetime. 相似文献