Magnetically Guidable Proteinaceous Adhesive Microbots for Targeted Locoregional Therapeutics Delivery in the Highly Dynamic Environment of the Esophagus

The esophagus is a tubular-shaped muscular organ where swallowed fluids and muscular contractions constitute a highly dynamic environment. The turbulent, coordinated processes that occur through the oropharyngeal conduit can often compromise targeted administration of therapeutic drugs to a lesion, significantly reducing therapeutic efficacy. Here, magnetically guidable drug vehicles capable of strongly adhering to target sites using a bioengineered mussel adhesive protein (MAP) to achieve localized delivery of therapeutic drugs against the hydrodynamic physiological conditions are proposed. A suite of highly uniform microparticles embedded with iron oxide (IO) nanoparticles (MAP@IO MPs) is microfluidically fabricated using the genipin-mediated covalent cross-linking of bioengineered MAP. The MAP@IO MPs are successfully targeted to a specific region and prolongedly retained in the tubular-structured passageway. In particular, orally administered MAP@IO MPs are effectively captured in the esophagus in vivo in a magnetically guidable manner. Moreover, doxorubicin (DOX)-loaded MAP@IO MPs exhibit a sustainable DOX release profile, effective anticancer therapeutic activity, and excellent biocompatibility. Thus, the magnetically guidable locomotion and robust underwater adhesive properties of the proteinaceous soft microbots can provide an intelligent modular approach for targeted locoregional therapeutics delivery to a specific lesion site in dynamic fluid-associated tubular organs such as the esophagus.     

Nanopoxia: Targeting Cancer Hypoxia by Antimonene-Based Nanoplatform for Precision Cancer Therapy

Most anticancer drugs with broad toxicities are systematically administrated to cancer patients and their distribution in tumors is extremely low owing to hypoxia, which compromises the therapeutic efficacies of these cancer drugs. Consequently, a preponderant proportion of cancer drugs is distributed in off-target-healthy tissues, which often causes severe adverse effects. Precision cancer therapy without overdosing patients with drugs remains one of the most challenging issues in cancer therapy. Here, a novel concept of nanopoxia is presented, which is a tumor-hypoxia-based photodynamic nanoplatform for the release of therapeutic agents to achieve precision cancer therapy. Under tumor hypoxia, exposure of tumors to laser irradiation induces the fracture of polymer outer shell and produces anticancer reactive oxygen species, and switches 2D antimonene (Sb) nanomaterials to cytotoxic trivalent antimony to synergistically kill tumors. In preclinical cancer models, delivery of Sb nanomaterials to mice virtually ablates tumor growth without producing any detectable adverse effects. Mechanistically, the tumor hypoxia-triggered generation of trivalent antimony displays direct damaging effects on cancer cells and suppression of tumor angiogenesis. Together, the study provides a proof-of-concept of hypoxia-based precision cancer therapy by developing a novel nanoplatform that offers multifarious mechanisms of cancer eradication.     

Fine-grained cooperative access control scheme with hidden policies

The traditional ciphertext policy attribute-based encryption (CP-ABE) has two problems:one is that the access policy must be embedded in the ciphertext and sent, which leads to the disclosure of user爷 s privacy information, the other is that it does not support collaborative decryption, which cannot meet the actual demand of conditional collaborative decryption among multiple users. In order to deal with the above two problems at the same time, a fine-grained cooperative access control scheme with hidden policies (FCAC-HP) is proposed based on the existing CP-ABE schemes combined with blockchain technology. In FCAC-HP scheme, users are grouped by group identifier so that only users within the same group can cooperate. In the data encryption stage, the access policy is encrypted and then embedded in the ciphertext to protect the privacy information of the access policy. In the data access stage, the anonymous attribute matching technology is introduced so that only matched users can decrypt ciphertext data to improve the efficiency of the system. In this process, a smart contract is used to execute the verification algorithm to ensure the credibility of the results. In terms of security, FCAC-HP scheme is based on the prime subgroup discriminative assumption and is proved to be indistinguishable under chosen plaintext attack (CPA) by dual system encryption technology. Experimental verification and analysis show that FCAC-HP scheme improves computational efficiency while implementing complex functions.     

pH‐Responsive,Light‐Triggered on‐Demand Antibiotic Release from Functional Metal–Organic Framework for Bacterial Infection Combination Therapy

To satisfy the ever‐growing demand in bacterial infection therapy and other fields of science, great effort is being devoted to the development of methods to precisely control drug release and achieve targeted use of an active substance at the right time and place. Here, a new strategy for bacterial infection combination therapy based on the light‐responsive zeolitic imidazolate framework (ZIF) is reported. A pH‐jump reagent is modified into the porous structure of ZIF nanoparticles as a gatekeeper, allowing the UV‐light (365 nm) responsive in situ production of acid, which subsequently induces pH‐dependent degradation of ZIF and promotes the release of the antibiotic loaded in the mesopores. The combination of the UV‐light, the pH‐triggered precise antibiotic release, and the zinc ions enables the light‐activated nanocomposite to significantly inhibit bacteria‐induced wound infection and accelerate wound healing, indicating a switchable and synergistic antibacterial effect. The light irradiated accumulation of acid ensures the controlled release of antibiotic and controlled degradation of ZIF, suggesting the therapeutic potential of the metal–organic frameworks‐based smart platform for controlling bacterial infection.     

Nickel@Nickel Oxide Core–Shell Electrode with Significantly Boosted Reactivity for Ultrahigh‐Energy and Stable Aqueous Ni–Zn Battery

The main bottlenecks of aqueous rechargeable Ni–Zn batteries are their relatively low energy density and poor cycling stability, mainly arising from the low capacity and inferior reversibility of the current Ni‐based cathodes. Additionally, the complicated and difficult‐to‐scale preparation procedures of these cathodes are not promising for large‐scale energy storage. Here, a facile and cost‐effective ultrasonic‐assisted strategy is developed to efficiently activate commercial Ni foam as a robust cathode for a high‐energy and stable aqueous rechargeable Ni–Zn battery. 3D Ni@NiO core–shell electrode with remarkably boosted reactivity and an area of 300 cm² is readily obtained by this ultrasonic‐assisted activation method (denoted as SANF). Benefiting from the in situ formation of electrochemically active NiO and porous 3D structure with a large surface area, the as‐fabricated SANF//Zn battery presents ultrahigh capacity (0.422 mA h cm^?2) and excellent cycling durability (92.5% after 1800 cycles). Moreover, this aqueous rechargeable SANF//Zn battery achieves an impressive energy density of 15.1 mW h cm^?3 (0.754 mW h cm^?2) and a peak power density of 1392 mW cm^?3, outperforming most reported aqueous rechargeable energy‐storage devices. These findings may provide valuable insights into designing large‐scale and high‐performance 3D electrodes for aqueous rechargeable batteries.     

ONVisor: Towards a scalable and flexible SDN‐based network virtualization platform on ONOS

Network virtualization (NV) technologies have attracted a lot of attention as an essential solution for future networking infrastructure. The NV enables multiple tenants to share the same physical infrastructure and to create independent virtual networks (VNs) by decoupling the physical network in terms of topology, address, and control functions. One feasible way to realize full NV involves considering solutions based on the software‐defined networking (SDN) paradigm using its programmability. The SDN contributes many benefits to both network operations and management including programmability, agility, elasticity, and flexibility. There are several SDN‐based NV solutions; however, they suffered from a lack of scalability, high availability. Also, they have high latency between control and data plane because of proxy‐based architecture. In this thesis, we introduce a new NV platform, named Open Network Hypervisor (ONVisor). The design objectives include, among the features, (1) multitenancy, (2) scalability, (3) flexibility, (4) isolated VNs, and (5) VN federation. ONVisor was designed and implemented by extending Open Network Operating System, an open‐source SDN controller. The main features of ONVisor are (1) isolated control and data plane per VN, (2) support of distributed operations, (3) extensible translators, (4) on‐platform VN application development and execution, and (5) support of heterogenous SDN data‐plane implementations. Several experiments are conducted on various test scenarios in different test environments in terms of control and data plane performance compared to nonvirtualized SDN network. The results show that ONVisor can provide VNs a little bit lower control plane performance and similar data plane performance.     

不锈钢表面光纤激光掩膜微细电解复合加工

为了实现不锈钢微细电解定域加工,提出激光掩膜表面改性微细电解复合加工技术。研发了激光掩膜微细电解复合加工装置,并进行样件加工试验。首先,采用光纤激光在304不锈钢表面扫描加热进行打标图案,利用X射线光电子能谱分析(XPS)对不锈钢表面激光打标图案进行分析,发现激光在不锈钢表面打标时被空气氧化生成铁、铬等氧化物,生成的打标图案具有耐腐蚀性,形成保护性掩膜。然后进行电解加工,由于掩膜图案在电解过程中起到保护作用,选择合适的电解加工参数,在不锈钢表面能加工复杂的微结构。最后利用SEM、光学轮廓仪来观测微结构形貌、粗糙度等。研究结果表明:利用激光表面改性,结合微细电解加工能实现304不锈钢微结构的快速加工,该工艺在微细加工领域具有很好的发展前景。     

非线性Jaynes—Cummings模型中原子的偶极压缩和相干俘获

本文运用全量子理论研究了与单模光场双光子作用的非线性Jaynes-Cummings模型系统中原子的是子行为,论证了原子发生相干俘获的条件,分别讲座了初场处于真空态（n=0)和热混态（n≠0）时非线性修正项和双光子失谐量对子原布居反转的演化特性和偶极压缩效应的影响。     

宽带高光束质量KrF激光器的实验研究

利用SBS作为相位共轭镜,对宽带KrF自由振荡激光器的光束质量进行了改善。在KrF激光能量为36mJ,脉宽为13.7ns,束散角为9.5倍衍射限的条件下,获得输出能量为20.8mJ,脉宽为4.3ns,束散角为6.4倍衍射限的高光束质量宽带KrF激光。     

合成孔径雷达实时成像转置存储器的两页式结构与实现

该文介绍了合成孔径雷达实时成像处理器转置存储器的基本工作原理,讨论了转置存储器的两种主要结构：三页式结构和两页式结构,并指出了这两种结构各自的优缺点。重点介绍了两页式转置存储器结构的典型应用,给出了以双数据率同步动态内存（DDR SDRAM）作为主存储器构成的两页式转置存储器的电路结构和实现结果。