A prospective study of the association between obesity and burnout among apparently healthy men and women.

The authors prospectively tested the hypothesis that obesity predicts burnout and the reverse-causation hypothesis that burnout predicts obesity. Respondents were 724 men and 340 women, apparently healthy employees, who underwent routine periodic health examinations at 2 points of time about 18 months apart. Obesity was assessed by body mass index, waist-hip ratio, and waist circumference. In regression analyses, done separately for men and women, the authors controlled for depressive symptomatology, sport activity, and Time 1 levels of the criterion. The hypothesis that burnout predicts obesity was not supported. The authors found that Time 1 measures of obesity predicted reductions rather than the hypothesized elevations of Time 2 burnout levels. The authors also found that for male respondents with relatively higher levels of Time 1 burnout, the higher their level of Time 1 obesity measure, the lower their level of T2 burnout. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Modulation of cocaine- and methamphetamine-induced behavioral sensitization by inhibition of brain nitric oxide synthase

Evidence suggests the existence of multiple interactions between dopamine, glutamate and nitric oxide (NO) in brain structures associated with psychomotor stimulation. The present study was undertaken to investigate the effect of the relatively selective inhibitor of the neuronal nitric oxide synthase (NOS) isoform, 7-nitroindazole (7-NI), on the development of sensitization to the locomotor stimulating effect of cocaine and methamphetamine (METH). Male Swiss Webster mice that received 15 mg/kg cocaine once a day for 5 days developed a marked locomotor sensitization to a challenge cocaine (15 mg/kg) or cross-sensitization to a challenge METH (0.5 mg/kg) injection given after a 10-day drug-free period. This treatment also produced a context-dependent sensitization as evident by the sensitized response to a challenge saline injection. Pretreatment with 7-NI (25 mg/kg) 30 min before cocaine administration (5 days) completely blocked the induction of sensitization to cocaine, the cross-sensitization to METH and the conditioned locomotion induced by cocaine. 7-NI when given alone, either acutely or for 5 days, had no significant effect on the locomotor activity of animals. Animals treated with METH (1.0 mg/kg) for 5 days developed marked sensitization to challenge METH (0.5 mg/kg), cross-sensitization to challenge cocaine (15 mg/kg) and context-dependent locomotion. Pretreatment with 7-NI (25 mg/kg) attenuated the sensitized response to METH and the cross-sensitization to cocaine as revealed after a 10-day drug-free period. However, the METH-induced conditioned locomotion was unaffected by the pretreatment with 7-NI. The present study supports the role of brain NO in the development of sensitization to both psychostimulants, cocaine and METH. However, it appears that the inability of 7-NI to completely abolish the sensitized responses induced after METH administration is the result of the resistible conditioned locomotion caused by METH, but not by cocaine.     

The Association Between Burnout, Depression, Anxiety, and Inflammation Biomarkers: C-Reactive Protein and Fibrinogen in Men and Women.

Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The authors controlled for possible confounders including 2 other negative affective states: depression and anxiety. In women, burnout was positively associated with hs-CRP and fibrinogen concentrations, and anxiety was negatively associated with them. In men, depression was positively associated with hs-CRP and fibrinogen concentrations, but not with burnout or anxiety. Thus, burnout, depression, and anxiety are differentially associated with microinflammation biomarkers, dependent on gender. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes

The deleterious effect of the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on dopaminergic neurons of the substantia nigra is well established. In addition, increased glutamatergic drive to basal ganglia output nuclei is considered a likely contributor to the pathogenesis of Parkinson's disease. One possibility for the increased excitatory tone may be related to an impairment in glutamate uptake. As astrocytes possess efficient transport mechanisms for both MPTP and glutamate, we have examined the effect of this agent on D-aspartate uptake into these cells. Treatment of cultures with 50 microM MPTP for 24 h decreased uptake by 39%. Kinetic analysis revealed that this effect was due to a 35% decrease in Vmax with no change in the Km. Treatment with deprenyl, a monoamine oxidase B inhibitor, produced a complete reversal of MPTP-induced uptake inhibition, but was ineffective following exposure of cells to the MPTP metabolite, 1-methyl-4-phenylpyridinium (MPP+). Removal of MPTP from cultures resulted in a complete restoration of glutamate uptake after 24 h. These results show that MPTP reversibly compromises glutamate uptake in cultured astrocytes, which is dependent on the conversion of MPTP to MPP+. Such findings suggest that the glutamate transporter in astrocytes plays an important role in MPTP-induced neurotoxicity and possibly in parkinsonism.     

Effect of the signal measured from the glottis on determination of the vocal tract shape

All-pole and pole-zero models for the vocal tract are developed. First an impulse train, then the pressure signal measured from the glottis, is used as the input in the models. The models for eight Turkish vowels produced by one male subject are studied to determine the effects of the presumed impulse train and the pressure signal measured from the glottis on the estimation of the vocal tract shape. The motion of the tongue is also examined for a whole word.     

Improved resistance to cyclic oxidation of a nickel-based superalloy by high temperature etching treatment (HTET)

A method to increase the cyclic oxidation resistance of a chromium and molybdenum rich nickel-based superalloy, Hastelloy-X (48 Ni22Cr18Fe9Mo), is presented, in which the cyclic oxidation resistance is increased at 1100°C. The time after which the total weight change becomes zero is increased from 100 to between 400 and 500 h. The method consists of thermally etching the alloy with gaseous hydrochloric acid (HCL) at 1100°C for approximately 0.5 h. The mechanism of the increased oxidation resistance was investigated using metallography, X-ray diffraction and electron microprobe analysis. As a result of the HTET, a thick and continuous protective subscale of Cr₈O₃ is formed during the oxidation which acts as an efficient diffusion barrier against further oxidation.     

One of the Bloodiest Days: A Comparative Analysis of Open and Closed Television News

This article analyzes television news reports, from five countries, dealing with an incident that took place in the West Bank village of Nahalin in April 1989 during the Palestinian uprising. The analysis of both the verbal and visual texts attempts to explicate "open" and "closed" presentations of the incident by referring to three dimensions: the rhetoric of balance, the rhetoric of facticity, and the rhetoric of neutrality. The analysis suggests that the stories by both Israel Television and CBS are relatively "closed," with the Israeli case being "defensive" while that of CBS being "offensive." The other versions are appraised as lying somewhere between poetic closure and journalistic openness.