REENGINEERING METHODOLOGIES AND TOOLS A Prescription for Enhancing Success

Companies are seeking methodologies and tools to facilitate well-disciplined and organized ways of structuring, assessing, and resolving the issues that business process reengineering raises. This article reviews approaches to BPR that can better your odds of success.     

Evaluation of hydroxylapatite/poly(l-lactide) composites: physico-chemical properties

The aim of this in vitro study was to examine the physico-chemical behaviour of hydroxylapatite/poly(l-lactide) (HA/PLLA) composites in solution tests. The polymer PLLA, the composites 30 wt% HA/PLLA (C30) and 50 wt% HA/PLLA (C50) and a one-side HA-coated PLLA (HAcP) were evaluated. Rectangular specimens were incubated in various acellular aqueous buffer solutions [citrate, Gomori's and phosphate-buffered saline (PBS)] up to 24 weeks. Data for cumulative release of calcium, phosphate and l-lactate release in solutions containing C30 or C50 showed linear patterns. Release data for solutions containing HAcP combined with scanning micrographs, X-ray microanalysis and X-ray diffraction patterns of the specimens in time showed that the plasma-sprayed HA coating on PLLA dissolves significantly, progressively in the first weeks and almost completely within the tested period of 24 weeks in vitro. A precipitate of scaly crystallites (calcium phosphates) was observed at the HA coating-PBS interface. After 24 weeks incubation all materials were still above their initial weight, indicating that swelling still exceeded dissolution. Application of C30, C50 and HAcP as implant materials seems interesting where initial stabilization through bone bonding is needed or where the linear release of constituents is a requirement. HAcP has the advantage that the HA coating acts as a hydrolysis barrier and consequently delays the degradation of PLLA in vitro.     

trans-2-phenylcyclopropylamine is a substrate for and inactivator of horseradish peroxidase

Horseradish peroxidase (HRP) is well known for mediating the electron-transfer oxidation of electron-rich aromatic 'donors' such as phenols and anilines, but has not been described to oxidize aliphatic amines. We here confirm the inability of HRP to oxidize typical aliphatic amines, even those which would exist significantly as free bases at the operative pH. In contrast, trans-2-phenylcyclopropylamine (2-PCPA) is both a substrate (turnover product is cinnamaldehyde) and a time-dependent inactivator of HRP. These activities of 2-PCPA are consistent with either a concerted or rapid sequential one-electron-oxidation/ring-opening to give an intermediate capable of covalent binding to the enzyme. 2-PCPA is the first known example of a simple aliphatic amine which serves as a substrate for HRP under turnover conditions.     

Natural convective flow between an array of vertical cylinders

The natural-convectioe flow of a viscous and heat-conducting fluid in systems of cylinders, arranged vertically in regular patterns, is studied. The aim of the study is to determine the conditions of stability of the fluid when heated from below and cooled from above. In particular, the influence of geometry and thermal properties of the system on the free stationary convection are studied. A new way of calculating the free convection threshold is proposed. The final results are analytical formulas for determining the critical Rayleigh numbers for the studied forms of flow and graphs, showing the dependency of these numbers on the geometrical parameters of arrays.     

Formation of linear aldehydes during surface water preozonization and their removal in water treatment in relation to mutagenic activity and sum parameters

Low molecular weight aldehydes were formed during surface water preozonization, their levels showing a positive correlation with increasing ozone dose applied and with increasing water temperature. A strong negative correlation was observed between aldehyde levels and U.V. absorbance at 254 nm.Coagulation had no influence on the aldehydes present and the influence of rapid double layer filtration varied strongly with temperature : significant removals were only observed above 10°C.Mutagenic activity generated by preozonization in Salmonella typhimurium TA98 shows an ozone dose depending relationship different from the formation of linear aldehydes. Its removal by coagulation is not effective but rapid double layer filtration reduces mutagenic activity to marginal levels.In this respect too no clear parallel can be drawn between the presence of low molecular weight aldehydes and mutagenic activity.     

The U.S. role in global internet governance

Who should control the Internet? A dozen years after the Internet became a mass medium, this issue has continued to grow in urgency, becoming white hot in fall 2005. At the September 2005 preparatory meeting for the UN World Summit on the Information Society (WSIS), a coalition of countries criticized the United States' unilateral control of the Internet's domain name system (DNS) and proposed the establishment of a multinational Council to supervise it. This proposal emerged from the Final Report of the UN Working Group on Internet Governance. Researchers from the Internet Governance Project, a university-based consortium for policy analysis, have concluded that the United States should internationalize governance of the Internet, but in a way that avoids intrusive, centralized control.     

RasterCalc: Calculus for Operations on Graphics Colour Rasters

An extended model and calculus, called RasterCalc, is presented for operations on discrete graphics rasters, including their colour functions. The operations are separated into two main categories: operations on domains, and operations on colour functions. The operations are further classified as local and remote, depending on the correspondence between destination and source pixels. The new raster element or pixel can be a function of a single element from one or more rasters, a function of a small area from other rasters, or a function of entire rasters. Local operations have their main applications in computer graphics, while remote operations are more oriented towards image processing. A mathematically oriented notation is used to define and represent the operations included. RasterCalc has been implemented as a procedure package in Pascal, to be used on a powerful, yet expensive display. Recently a C version has been completed for a personal colour computer with a special chip for raster operations. The work reported in this paper is partially supplied by the Dutch Technical Sciences Foundation, under project number LWI 14.0130: “Facilities for raster graphics in programming languages”     

A new method for the electro-optical measuring of fast high voltage pulses

This report describes a new method for measuring fast high voltage electric pulses based on one particular application of the Kerr effect. This work was carried out in order to further the development of optical particle detectors. At the present time with our method, the minimum risetime of the measured pulse reaches the nanosecond domain while the maximum voltage is limited only by the physical dimension of the electro-optical transducer.The measuring principle chosen requires a new calibration method in order to reconstruct the observed signal.The use of nitrobenzol as the active liquid allows the continuous modification of the cell sensitivity over a ratio of 1 to 3 without changing the geometry of the cell.