Determination of photoinitiated polymerization of multifunctional acrylates with acetic acid derivatives of thioxanthone by RT-FTIR

Photopolymerization of multifunctional acrylates with 2-thioxanthone-thioacetic acid (TXSCH₂COOH) and 2-(carboxymethoxy) thioxanthone (TXOCH₂COOH) as the one-component photoinitiator has been investigated by real-time Fourier transform infrared (RT-FTIR) spectroscopy. The photobleaching of these one-component nature initiators was performed in air. The irradiation time for total bleaching was 240 s for TXSCH₂COOH and 540 s for TXOCH₂COOH.     

Experimental investigation of the performance of a solar‐assisted ground‐source heat pump system for greenhouse heating

The main objective of the present study is to investigate the performance characteristics of a solar‐assisted ground‐source heat pump system (SAGSHPS) for greenhouse heating with a 50 m vertical 1¼ in nominal diameter U‐bend ground heat exchanger. This system was designed and installed in the Solar Energy Institute, Ege University, Izmir (568 degree days cooling, base: 22°C, 1226 degree days heating, base: 18°C), Turkey. Based upon the measurements made in the heating mode, the heat extraction rate from the soil is found to be, on average, 54.08 Wm^?1 of bore depth, while the required borehole length in meter per kW of heating capacity is obtained as 12.57. The entering water temperature to the unit ranges from 8.2 to 16.2°C, with an average value of 9.1°C. The greenhouse air is at a maximum day temperature of 25°C and night temperature of 14°C with a relative humidity of 40%. The heating coefficient of performance of the heat pump (COP_HP) is about 2.13 at the end of a cloudy day, while it is about 2.84 at the end of sunny day and fluctuates between these values in other times. The COP values for the whole system are also obtained to be 5–15% lower than COP_HP. Copyright © 2004 John Wiley & Sons, Ltd.     

Medicinal importance of grapefruit juice and its interaction with various drugs

Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P – 450 3A4 system, which is responsible for the first pass metabolism of many drugs. The P – glycoprotein pump, found in the brush border of the intestinal wall which transports many of these cytochrome P – 450 3A4 substrates, has also been implicated to be inhibited by grapefruit juice. By inhibiting these enzyme systems, grapefruit juice alters the pharmacokinetics of a variety of medications, leading to elevation of their serum concentrations. Most notable are its effects on the calcium channel antagonist and the statin group of drugs. In the case of many drugs, the increased serum concentration has been found to be associated with increased frequency of dose dependent adverse effects. In this review, we have discussed the phytochemistry of grapefruit juice, the various drugs involved in the drug – grapefruit juice eraction with their mechanisms of action and have presented the clinical implications of these interactions.     

Second law analysis of two‐stage compression transcritical CO2 heat pump cycle

Because of the global warming impact of hydro fluorocarbons, the uses of natural refrigerants in automotive and HVAC industries have received worldwide attention. CO₂ is the most promising refrigerant in these industries, especially the transcritical CO₂ refrigeration cycle. The objective of this work is to identify the main factors that affect two‐stage compression transcritical CO₂ system efficiency. A second law of thermodynamic analysis on the entire two‐stage CO₂ cycle is conducted so that the exergy destruction of each system component can be deduced and ranked, allowing future efforts to focus on improving the components that have the highest potential for advancement. The inter‐stage pressure is used as a variable parameter in the analysis study. The second law efficiency, coefficient of cooling performance and total exergy destruction of the system variations with the inter‐stage pressure are presented graphically. It was concluded that there is an optimum inter‐stage pressure that maximizes both first law and second law efficiencies. Copyright © 2008 John Wiley & Sons, Ltd.     

Fluorescent Probes for G‐Quadruplex Structures

Mounting evidence supports the presence of biologically relevant G‐quadruplexes in single‐cell organisms, but the existence of endogenous G‐quadruplex structures in mammalian cells remains highly controversial. This is due, in part, to the common misconception that DNA and RNA molecules are passive information carriers with relatively little structural or functional complexity. For those working in the field, however, the lack of available tools for characterizing DNA structures in vivo remains a major limitation to addressing fundamental questions about structure–function relationships of nucleic acids. In this review, we present progress towards the direct detection of G‐quadruplex structures by using small molecules and modified oligonucleotides as fluorescent probes. While most development has focused on cell‐permeable probes that selectively bind to G‐quadruplex structures with high affinity, these same probes can induce G‐quadruplex folding, thereby making the native conformation of the DNA or RNA molecule (i.e., in the absence of probe) uncertain. For this reason, modified oligonucleotides and fluorescent base analogues that serve as “internal” fluorescent probes are presented as an orthogonal means for detecting conformational changes, without necessarily perturbing the equilibria between G‐quadruplex, single‐stranded, and duplex DNA. The major challenges and motivation for the development of fluorescent probes for G‐quadruplex structures are presented, along with a summary of the key photophysical, biophysical, and biological properties of reported examples.     

Vapor-Phase Thermal Conductivity Measurements of Refrigerants

The paper reports further developments of the transient hot-wire technique. The particular development of interest is the extension of the technique to study polar, or electrically-conducting gases with a relatively low thermal conductivity but a high thermal diffusivity, circumstances which occur at low density and therefore low pressure, for gases of high molecular weight. The theory of the transient hot-wire instrument is examined again in order to guide a revised design of the thermal conductivity cell with this particular application in mind. Test measurements have then been conducted on helium, argon, and propane at low and moderate pressures to confirm that the instrument operates in accordance with the theory of it. The satisfactory completion of these tests demonstrates that the new equipment overcomes many of the defects observed in earlier variants of the instrument for application to the study of refrigerant gases.