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1.
Modern information systems rely more and more on combining concurrent, distributed, mobile and heterogenous components. This move from old systems, typically conceived in isolation, induces the need for new languages and software architectures. In particular, coordination languages have been proposed to cleanly separate computational aspects and communication. On the other hand, software architects face the problem of specifying and reasoning about non-functional requirements. All these issues are widely perceived as fundamental to improve software productivity, to enhance maintainability, to advocate modularity, to promote reusability, and to lead to systems more tractable and more amenable to verification and global analysis.The FOCLASA workshop was organized on August 24th 2002 as a satellite event of Concur'02 with the aim of bringing together researchers working on the foundations of component-based computing, coordination, and software architectures.This volume contains selected 12 papers presented at the workshop. They were reviewed by the program committee, consisting, besides the editors, of
• Rocco De Nicola (University of Firenze, Italy)
• Jos Luiz Fiadeiro (ATX Software and University of Lisbon, Portugal)
• Roberto Gorrieri (University of Bologna, Italy)
• Paola Inverardi (University L'Aquila, Italy)
• Joost Kok (University of Leiden, The Netherlands)
• Antonio Porto (New University of Lisbon, Portugal)
We would like to thank them together with the authors of the papers for their contribution to the meeting. We would also like to thank Michael Mislove for his help in editing this volume. Finally, we are grateful to L. Brim, M. Kretinsky, and A. Kucera for their help in organizing the workshop in Brno.  相似文献   
2.
Wireless LAN technologies such as IEEE 802.11a and 802.11b support high bandwidth and multi-rate data transmission to match the channel condition (i.e., signal to noise ratio). While some wireless packet fair queuing algorithms to achieve the per-flow throughput fairness have been proposed, they are not appropriate for guaranteeing QoS in multi-rate wireless LAN environments. We propose a wireless packet scheduling algorithm that uses the multi-state (multi-rate) wireless channel model and performs packet scheduling by taking into account the channel usage time of each flow. The proposed algorithm aims at per-flow protection by providing equal channel usage time for each flow. To achieve the per-flow protection, we propose a temporally fair scheduling algorithm called Contention-Aware Temporally fair Scheduling (CATS) which provides equal channel usage time for each flow. Channel usage time is defined as the sum of the packet transmission time and the contention overhead time due to the CSMA/CA mechanism. The CATS algorithm provides per-flow protection in wireless LAN environments where the channel qualities of mobile stations are dynamic over time, and where the packet sizes are application-dependent. We also extend CATS to Decentralized-CATS (D-CATS) to provide per-flow protection in the uplink transmission. Using an NS-2 simulation, we evaluate the fairness property of both CATS and D-CATS in various scenarios. Simulation results show that the throughput of mobile stations with stable link conditions is not degraded by the mobility (or link instability) of other stations or by packet size variations. D-CATS also shows less delay and less delay jitter than FIFO. In addition, since D-CATS can coordinate the number of contending mobile stations, the overall throughput is not degraded as the number of mobile stations increases. This work was supported in part by the Brain Korea 21 project of Ministry of Education and in part by the National Research Laboratory project of Ministry of Science and Technology, 2004, Korea.  相似文献   
3.
A new RF switched capacitor bandpass filter and its command circuit made up of a ring voltage controlled oscillator with ‘XOR’ gates are proposed. Implemented in a standard CMOS technology, this circuit is intended to be used in a subset of professional mobile phone applications [380–520 MHz]. Experiments carried out on a prototype show a tunable center frequency range of 260 MHz [240–500 MHz], with a quality factor that can be as high as 300.  相似文献   
4.
This article presents a network-controlled approach of user terminal mobility within anIP based WirelessLAN Access Network. In a first part, this article makes a review of the mobility support, on the subject of emergingWLAN technologies asHIPERLAN/2 andIEEE 802.11, on the one hand, and, regardingIP networks as currently studied withinIETF, on the other hand. Both types ofIP mobility protocols are presented, either global mobility protocols such as MobileIP, or local mobility management protocols (micro mobility). In the next part, the overall principles of our mobility management approach are explained; this approach is based on the implementation of a new network entity dedicated to the control of user terminal mobility. The last part details a practical implementation of this approach. The implementation is carried out on the basis of Hierarchical MobileIPv6 (HMIPv6). The experimental results confirm the importance to carefully plan and control the user terminal mobility within largeIP based Access Networks, as this brings benefit to the user as well as to the operator.  相似文献   
5.
Abstract

The constituents of the essential oil extracted from the needles and twigs of white spruce - Picea glauca (Moench) Voss -by steam distillation are analyzed by GC-MS and GC with authentic samples. The analysis allows for the Identification of 39 constituents.  相似文献   
6.
Polyphosphorylated and perphosphorylated hexopyranose monosaccharides and disaccharides were synthesized from parent or partially protected carbohydrates as potential allosteric effectors of hemoglobin. A study toward the construction of seven- and eight-membered cyclic pyrophosphates was also performed on the sugars which had the proper orientation, protection, and number of phosphates. All final compounds were tested for their efficiency on oxygen release from human hemoglobin. Several compounds presented higher potency than myo-inositol hexakisphosphate, which is the most efficient of the known allosteric effectors of hemoglobin. Structure-activity relationships were analyzed. The affinity and efficiency depend on the number of phosphates attached to the carbohydrate skeleton and are related primarily to the number of negative charges present. Other effects operate, but play a lesser role.  相似文献   
7.
Myo-inositol trispyrophosphate (ITPP), a synthetic allosteric effector of hemoglobin, increases the regulated oxygen-releasing capacity of red blood cells (RBCs), leading to suppression of hypoxia-inducible factor 1α (HIF-1α) and to down-regulation of hypoxia-inducible genes such as vascular endothelial growth factor (VEGF). As a consequence, tumor growth is markedly affected. The effect of weekly intravenous injection of ITPP on an orthotopic, syngenic rat hepatocellular carcinoma (HCC) model was compared to that for untreated animals and animals subjected to conventional Doxorubicin chemotherapy. The longitudinal examination of HCC was performed by microCT imaging, and the cellular and molecular changes were evaluated by histology and Western blotting analysis of HIF-1α, VEGF, and caspase-3 gene expression in the tumor and in the surrounding liver. Hematologic impact was evaluated by blood cell-count measurement and determination of P50 (oxygen partial pressure for a 50 % oxygen saturation of hemoglobin). The HCC evaluation by microCT revealed a high potency of ITPP for tumor growth inhibition, thus allowing long-term survival and even cure of almost all the treated animals. The P50 value of hemoglobin in RBCs underwent a shift of 30 % following ITPP injection. Under these conditions, HIF-1α activity was strongly decreased, VEGF expression was down-regulated, and apoptosis was induced in HCC and surrounding liver cells, as indicated by Caspase-3 expression. ITPP did not affect hematologic parameters during treatment. The observations of in vivo tumor eradication suggest a significant clinical potential for ITPP in cancer therapy.  相似文献   
8.
The morphology of solution grown single crystals of a series of double crystalline diblock copolymers derived from l-lactide and ?-caprolactone has been investigated by means of transmission electron microscopy. The copolymers had a variable composition with a poly(l-lactide) weight percentage that ranged between 81 and 10%. All samples had a low polydispersity index (1.4-1.1) and a similar number average molecular weight (20,000-35,000 g/mol).Bulk crystallization and melting behaviour of diblock copolymers were evaluated by DSC and the results demonstrated the double crystalline nature of the samples. Fractionated crystallization clearly occurred in copolymers having an intermediate composition.Isothermal crystallizations were performed in dilute n-hexanol solutions at temperatures that ranged between 80 and 50 °C. Crystal morphologies were dependent on the crystallization temperature and even on the composition. Thus, the inability of poly(?-caprolactone) (PCL) blocks to crystallize between 80 and 70 °C rendered lozenge, truncated and spindle-shaped crystals associated to the poly(l-lactide) (PLLA) block. These usually had thicker edges due to PLLA overgrowths that mainly took place in their periphery. However, an overgrowth of irregular PCL crystals during subsequent cooling and crystallization at room temperature was also detected. Complex morphologies constituted by lamellar crystals of both PCL and PLLA blocks were developed at intermediate temperatures (70-65 °C), whereas elongated hexagonal morphologies mainly associated to the PCL block were detected at the lowest crystallization temperature. In general, electron diffraction patterns showed for all samples’ reflections associated to both poly(?-caprolactone) and poly(l-lactide) (α-form) crystals. The relative intensity between the two types of reflections varied according to the copolymer composition.  相似文献   
9.
Nonspecific binding (NSB) is a key parameter in optimizing PET imaging tracers. We compared the ability to predict NSB of three available methods: LIMBA, rat fu,brain, and CHI(IAM). Even though NSB is often associated with lipophilicity, we observed that logD does not correlate with any of these assays, clearly indicating that lipophilicity, while influencing NSB, is insufficient to predict it. A cross-comparison of the methods showed that all three correlate and are useful predictors of NSB. The three assays, however, rank the molecules slightly differently, illustrating the challenge of comparing molecules within a narrow chemical space. We also noted that CHI(IAM) values more effectively predict VNS, a measure of in vivo NSB in the human brain. CHI(IAM) measurements might be a closer model of the actual physicochemical interaction between PET tracer candidates and cell membranes, and seems to be the method of choice for the optimization of in vivo NSB.  相似文献   
10.
Galacto- and fuco-clusters conjugated with one to three catechol or hydroxamate motifs were synthesised to target LecA and LecB lectins of Pseudomonas aeruginosa (PA) localised in the outer membrane and inside the bacterium. The resulting glycocluster–pseudosiderophore conjugates were evaluated as Trojan horses to cross the outer membrane of PA by iron transport. The data suggest that glycoclusters with catechol moieties are able to hijack the iron transport, whereas those with hydroxamates showed strong nonspecific interactions. Mono- and tricatechol galactoclusters ( G1C and G3C ) were evaluated as inhibitors of infection by PA in comparison with the free galactocluster ( G0 ). All of them exhibited an inhibitory effect between 46 to 75 % at 100 μM, with a higher potency than G0 . This result shows that LecA localised in the outer membrane of PA is involved in the infection mechanism.  相似文献   
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