LC-VCO design optimization at 1/f 2 phase noise performance in 65 nm CMOS technology

A way of analytical calculation in the phase noise modeling of the LC-VCO topology without tail current resource is proposed. The noise current imported by the MOS channel is modeled to give approximate evaluation, and the period of the transistor noise is included in the model. Phase noise introduced by the tank loss resistance is also modeled to evaluate the circuit phase noise performance. The circuit has been implemented in a 65 nm CMOS technology. The chip occupies 951 × 705 um² areas with the buffer and pads. The test result indicates that the VCO core consumes 1.125 mW with a 1.2 V power supply, the frequency of the VCO baseband is from 1.258 to 1.37 GHz, and the multiband frequency is from 0.86 to 1.37 GHz. The best performance of the LC-VCO shows a phase noise of ?129.57 dBc/Hz at 1 MHz offset frequency from a 1.3 GHz carrier, resulting in an excellent FoM of ?191.27 dBc/Hz.     

Adaptive error coding using channel prediction

In this paper, we construct a finite-state Markov chain model for a Rayleigh fading channel by partitioning the range of the received signal envelope into K intervals. Using a simulation of the classic two-ray Rayleigh fading model, a Markov transition probability matrix is obtained. Using this matrix to predict the channel state, we introduce an adaptive forward error correction (FEC) coding scheme. Simulation results are presented to show that the adaptive FEC coding scheme significantly improves the performance of a wireless communication system.     

区域影像辅助诊断中心建设的实践与思考

区域影像辅助诊断中心的建立和应用,不仅有利于提高基层医疗卫生服务机构的医疗服务水平,更有利于提升普通患者的就医体验。浦东新区围绕医改就基于医疗联合体模式的区域影像辅助诊断中心的建设进行了一些研究性的探索。本文对已有的试点建设方案进行了分析和总结,并思考基于区域卫生信息平台建设区域影像辅助诊断中心的方案。     

Characterization of a new type HPV16 E7 variant isolated from cervical cancer highest incidence area in Hubei Province of China

AIM: To investigate the variation and biological properties of HPV16 E7 isolated from cervical cancer biopsy samples from highest incidence area in HuBei province of China. METHODS: HVP16 E7 sequences isolated from the cervical cancer biopsies of 10 local patients were amplified, sequenced and compared with prototype E7 gene. Then the variant gene was cloned into different vectors to study the antigenicity, expression and immunogenicity of its protein by Western blot, immunofluorescence and genetic immunization in vitro or in vivo. RESULTS: The results showed that 7 of 10 samples had the same mutations which led to a nonsense mutation at codon 43 of E7 sequence. The truncated E7 protein could be recognized by standard E7 monoclonal antibody in Western blot and expressed in NIH3T3 cells. In the blood sera of mice immunized intramuscularly by the plasmid DNA expressing the variant E7 gene specific E7 antibodies could be detected at week 2, 3, 5 and 6 after inoculation. However, no specific lymphoproliferation after E7 protein stimulation in vitro was detected by MTT colorimetric assay in comparison to the prototype E7 protein. CONCLUSION: HPV16 E7 gene may show variation in China and the variant protein could be expressed and induce host humoral immune response, but could not elicit special cellular-immune response against it. These data might hold the key for future development of HPV16 vaccine in HuBei province of China.     

Speed and accuracy comparison of techniques for multiuser detection in synchronous CDMA

In this letter, we compare the complexity and efficiency of several methods used for multiuser detection in a synchronous code-division multiple-access system. Various methods are discussed, including decision-feedback (DF) detection, group decision-feedback (GDF) detection, coordinate descent, quadratic programming with constraints, space-alternating generalized EM (SAGE) detection, Tabu search, a Boltzmann machine detector, semidefinite relaxation, probabilistic data association (PDA), branch and bound (BBD), and the sphere decoding (SD) method. The efficiencies of the algorithms, defined as the probability of group detection error divided by the number of floating point computations, are compared under various situations. Of particular interest is the appearance of an "efficient frontier" of algorithms, primarily composed of DF detector, GDF detector, PDA detector, the BBD optimal algorithm, and the SD method. The efficient frontier is the convex hull of algorithms as plotted on probability of error versus computational demands axes: algorithms not on this efficient frontier can be considered dominated by those that are.     

Over-erase phenomenon in SONOS-type flash memory and its minimization using a hafnium oxide charge storage Layer

The over-erase phenomenon in the polysilicon-oxide-silicon nitride-oxide-silicon (SONOS) memory structure is minimized by using hafnium oxide or hafnium aluminum oxide to replace silicon nitride as the charge storage layer (the resulting structures are termed SOHOS devices, where the "H" denotes the high dielectric constant material instead of silicon nitride). Unlike SONOS devices, SOHOS structures show a reduced over-erase phenomenon and self-limiting charge storage behavior under both erase and program operations. These are attributed to the differences in band offset and the crystallinity of the charge storage layer.     

Remarkable Antibacterial Activity of Reduced Graphene Oxide Functionalized by Copper Ions

Despite long-term efforts for exploring antibacterial agents or drugs, potentiating antibacterial activity and meanwhile minimizing toxicity to the environment remains a challenge. Here, it is experimentally shown that the functionality of reduced graphene oxide (rGO) through copper ions displays selective antibacterial activity that is significantly stronger than that of rGO itself and no toxicity to mammalian cells. Remarkably, this antibacterial activity is two-orders-of-magnitude greater than the activity of its surrounding copper ions. It is demonstrated that rGO is functionalized through the cation–π interaction to massively adsorb copper ions to form a rGO–copper composite and result in an extremely low concentration level of surrounding copper ions (less than ≈0.5 µm ). These copper ions on rGO are positively charged and strongly interact with negatively charged bacterial cells to selectively achieve antibacterial activity, while rGO exhibits the functionality to not only actuate rapid delivery of copper ions and massive assembly onto bacterial cells but also result in the valence shift in the copper ions from Cu²⁺ into Cu⁺, which greatly enhances the antibacterial activity. Notably, this rGO functionality through cation–π interaction with copper ions can similarly achieve algaecidal activity but does not exert cytotoxicity against neutrally charged mammalian cells.     

Printing Reconfigurable Bundles of Dielectric Elastomer Fibers

Active soft materials that change shape on demand are of interest for a myriad of applications, including soft robotics, biomedical devices, and adaptive systems. Despite recent advances, the ability to rapidly design and fabricate active matter in complex, reconfigurable layouts remains challenging. Here, the 3D printing of core-sheath-shell dielectric elastomer fibers (DEF) and fiber bundles with programmable actuation is reported. Complex shape morphing responses are achieved by printing individually addressable fibers within 3D architectures, including vertical coils and fiber bundles. These DEF devices exhibit resonance frequencies up to 700 Hz and lifetimes exceeding 2.6 million cycles. The multimaterial, multicore-shell 3D printing method opens new avenues for creating active soft matter with fast programable actuation.     

Engineering 2D Arsenic-Phosphorus Theranostic Nanosheets

As an anticancer drugs, arsenic trioxide (ATO) has been certified to efficiently treat refractory acute promyelocytic leukemia (APL). Unfortunately it suffers from limited therapeutic potency for solid tumors due to its in vivo restricted administration dose and rapid renal clearance. Herein, distinct 2D arsenic-phosphorus (AsP) nanosheets are engineered by adopting an alloy strategy followed by exfoliation, which can confine toxic arsenic into AsP crystals, thus significantly improving the biosafety and biocompatibility of arsenic-based chemotherapeutic drugs. Of particular note, the high light absorption and strong photothermal-conversion efficiency (37.6%) in the second near infrared biowindow (NIR-II) of AsP nanosheets not only endow them with desirable contrast-enhanced photoacoustic imaging properties, but also achieve efficient local tumor hyperthermia, which further synergistically triggers the in-situ transformation from low toxic/nontoxic AsP crystals into highly toxic arsenic species, exerting a strong arsenic-mediated antineoplastic effect. Both in vitro and in vivo data verify the synergy between photonic therapy in NIR-II and enhanced chemotherapy as enabled by AsP nanosheets, paving the way for efficient nanomedicine-enabled arsenic-based chemotherapeutic tumor treatment.     

基于仿真技术的雷达软件测试

文中通过仿真技术,实现了一种雷达软件测试方法。搭建了基于仿真技术的雷达软件测试架构,将仿真信号注入雷达系统的不同部分实现不同模块的测试。重点研究雷达目标航路模拟及射频信号仿真,并针对性的测试雷达软件异常值、边界值、丢帧、大数据量等情况。该雷达仿真系统在实际雷达软件测试中应用,达到了预期效果。