A dielectric-modulated field-effect transistor for biosensing

Interest in biosensors based on field-effect transistors (FETs), where an electrically operated gate controls the flow of charge through a semiconducting channel, is driven by the prospect of integrating biodetection capabilities into existing semiconductor technology. In a number of proposed FET biosensors, surface interactions with biomolecules in solution affect the operation of the gate or the channel. However, these devices often have limited sensitivity. We show here that a FET biosensor with a vertical gap is sensitive to the specific binding of streptavidin to biotin. The binding of the streptavidin changes the dielectric constant (and capacitance) of the gate, resulting in a large shift in the threshold voltage for operating the FET. The vertical gap is fabricated using simple thin-film deposition and wet-etching techniques. This may be an advantage over planar nanogap FETs, which require lithographic processing. We believe that the dielectric-modulated FET (DMFET) provides a useful approach towards biomolecular detection that could be extended to a number of other systems.     

A flexible depth probe using liquid crystal polymer

We proposed a method of making a flexible depth-type neural probe using liquid crystal polymer. Conventional depth neural probes made of metal or silicon have the limitations of a single recording site per shank or the brittleness of the silicon substrate. To avoid these drawbacks, polymer-based depth neural probes have been developed with biocompatible polymers such as polyimides or parylenes. However, those have suffered from the difficulty of inserting the probes into brain tissues due to their high flexibility, requiring mechanical reinforcements. Herein, we report the first attempt to use a flexible material, liquid crystal polymer (LCP), as a substrate for a depth-type neural probe. The LCP-based probe offers a controllable stiffness vs. flexibility and compatibility with thin-film processes in addition to its inherent characteristics such as high reliability and biocompatibility. In the present study, an LCP neural probe was fabricated to have enough stiffness to penetrate the dura mater of rodent brains without a guide tool or additional reinforcement structures. A simultaneous multichannel neural recording was successfully achieved from the somatosensory motor cortex of the rodents. Immunohistochemistry showed that the electrodes could be inserted into the desired regions in the brain.     

Development and evaluation of intelligent machine tools based on knowledge evolution in M2M environment

In the near future, the foreseen improvement in machine tools will be in the form of a knowledge evolution-based intelligent device. The goal of this study is to develop intelligent machine tools having knowledge-evolution capability in Machine to Machine (M2M) wired and wireless environment. The knowledge evolution-based intelligent machine tools are expected to be capable of gathering knowledge autonomously, producing knowledge, understanding knowledge, applying reasoning to knowledge, making new decisions, dialoguing with other machines, etc. The concept of the knowledge-evolution intelligent machine originated from the process of machine control operation by the sense, dialogue and decision of a human expert. The structure of knowledge evolution in M2M and the scheme for a dialogue agent among agent-based modules such as a sensory agent, a dialogue agent and an expert system (decision support agent) are presented in this paper, and work-offset compensation from thermal change and recommendation of cutting condition are performed on-line for knowledge-evolution verification.     

Surface Modification of Exfoliated Layered Gadolinium Hydroxide for the Development of Multimodal Contrast Agents for MRI and Fluorescence Imaging

A novel method for modifying the surface of magnetic‐resonance‐contrasting layered gadolinium hydroxide (LGdH) is developed providing them with water‐ and bio‐compatibility and acid‐resistance, all of which are essential for medical applications. A stable colloid of exfoliated layers is synthesized by exchanging interlayer anions of LGdH with oleate ions. The delaminated layers are successively coated with phospholipids with poly(ethylene glycol) tail groups, and their effectiveness as a contrast agent for magnetic resonance imaging (MRI) is demonstrated. The adaptability of this surface modification approach for incorporating functional molecules and fabricating a fluorescent colloid of LGdH, which has the potential utility as a multimodal probe, is also demonstrated. This result provides a novel approach for expanding the applications of layered inorganic materials and developing a new class of MRI contrast agents.     

Effects of oxygen stoichiometry on resistive switching properties in amorphous tungsten oxide films

The bipolar resistance switching in WO_3 + δ films sandwiched by Al and Pt electrodes was investigated by changing additional oxygen content (δ). Reliable switching voltages and retention were observed for all samples. As δ increases the bi-stable current-voltage characteristics fluctuate leading to unstable switching power consumption. An analysis of the temperature dependence of the bi-stable resistance states revealed additional features that thermionic emission and metallic conduction co-contribute to the electrical transport of the resistance states. The authors propose that the observed resistance switching is due to the combined effects of potential modification near the interface and the formation of a metallic channel.     

Thermally controlled wavelength locker integrated in widely tunable SGDBR-LD module

A sampled-grating distributed Bragg reflector laser module having an integrated multiwavelength locker has been developed and evaluated. The uniquely designed wavelength locker made of thermally controlled etalon has provided uniform wavelength monitoring and very stable wavelength locking in the 188-ITU grid channels (37 nm) with 25-GHz spacing. Over the case temperature from -5/spl deg/C to 65/spl deg/C, the laser wavelength was locked within /spl plusmn/0.5 GHz, and the total power consumption of the module was less than 4 W.     

Novel ESD strategy for high voltage non-volatile programming pin application

This paper presents a novel ESD strategy for non-volatile memory (NVM) programming pin in a 0.13um/30V technology. Suggested scheme can provide not only a major current discharge path to protect the internal circuit from ESD damage but also a voltage clamping function to prevent the soft error of programmed data during the ESD event. It has been validated by TLP experiments and TCAD simulation.     

O/sup 2/ABA: a novel high-performance predictable circuit architecture for the deep submicron era

Current VLSI design techniques focus on four major goals: higher integration, faster speed, lower power, and shorter time-to-market. These goals have been accomplished mainly by deep submicron (DSM) technology along with voltage scaling. However, scaling down of feature size causes larger interwire capacitance which results in large crosstalk between interconnects. In this paper, we propose a novel predictable circuit architecture, named "optimized overlaying array-based architecture" (O/sup 2/ABA), especially suited for the deep submicron regime. O/sup 2/ABA achieves reduction in crosstalk by considering the current directions and by reducing interwire capacitance. The introduction of "unit cell" leads to regularity, which makes the performance predictable even before layout, and shortens design time. O/sup 2/ABA is compared with other design styles, such as custom design and standard cell approach, in terms of coupling capacitance, area, and delay.     

Fabrication of Ordered Nanostructured Arrays Using Poly(dimethylsiloxane) Replica Molds Based on Three‐Dimensional Colloidal Crystals

Hexagonally arrayed structures of colloidal crystals with uniform surface are a good candidate for master molds to be used in soft lithography. Here, the fabrication of periodically arrayed nanostructures using poly(dimethylsiloxane) (PDMS) molds based on three‐dimensionally (3D) ordered colloidal crystals is reported. A robust, high‐quality 3D colloidal‐crystal master molds is prepared using the colloidal suspension containing a water‐soluble polymer. The surface patterns of the 3D colloidal crystals can then be transferred onto a polymer film via soft lithography, by means of the replication of the surface pattern with PDMS. Various hexagonally arrayed nanostructure patterns can be fabricated, including close‐packed and non‐close‐packed 2D arrays and honeycomb structures by the structural modification of the 3D colloidal‐crystal templates. The replicated hexagonally arrayed structures can also be used as templates for producing colloidal crystals with 2D superlattices.