全文获取类型
收费全文 | 652篇 |
免费 | 25篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 28篇 |
化学工业 | 193篇 |
金属工艺 | 12篇 |
机械仪表 | 13篇 |
建筑科学 | 28篇 |
矿业工程 | 1篇 |
能源动力 | 27篇 |
轻工业 | 79篇 |
无线电 | 37篇 |
一般工业技术 | 131篇 |
冶金工业 | 51篇 |
原子能技术 | 11篇 |
自动化技术 | 67篇 |
出版年
2023年 | 6篇 |
2022年 | 13篇 |
2021年 | 22篇 |
2020年 | 7篇 |
2019年 | 14篇 |
2018年 | 17篇 |
2017年 | 11篇 |
2016年 | 19篇 |
2015年 | 12篇 |
2014年 | 21篇 |
2013年 | 36篇 |
2012年 | 23篇 |
2011年 | 54篇 |
2010年 | 41篇 |
2009年 | 26篇 |
2008年 | 22篇 |
2007年 | 46篇 |
2006年 | 26篇 |
2005年 | 27篇 |
2004年 | 17篇 |
2003年 | 29篇 |
2002年 | 16篇 |
2001年 | 6篇 |
2000年 | 16篇 |
1999年 | 15篇 |
1998年 | 21篇 |
1997年 | 9篇 |
1996年 | 16篇 |
1995年 | 8篇 |
1994年 | 16篇 |
1993年 | 7篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 7篇 |
1989年 | 3篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 1篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1981年 | 8篇 |
1980年 | 4篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有678条查询结果,搜索用时 15 毫秒
51.
52.
Kazunori Kageyama Yasumasa Iwasaki Yutaka Watanuki Kanako Niioka Makoto Daimon 《International journal of molecular sciences》2021,22(11)
The hypothalamic-pituitary-adrenal axis is stimulated in response to stress. When activated, it is suppressed by the negative feedback effect of glucocorticoids. Glucocorticoids directly inhibit proopiomelanocortin (Pomc) gene expression in the pituitary. Glucocorticoid signaling is mediated via glucocorticoid receptors, 11β-hydroxysteroid dehydrogenases, and the FK506-binding immunophilins, Fkbp4 and Fkbp5. Fkbp4 and Fkbp5 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor, resulting in modulation of the glucocorticoid action. Here, we explored the regulation of Fkbp4 and Fkbp5 genes and their proteins with dexamethasone, a major synthetic glucocorticoid drug, in murine AtT-20 corticotroph cells. To elucidate further roles of Fkbp4 and Fkbp5, we examined their effects on Pomc mRNA levels in corticotroph cells. Dexamethasone decreased Pomc mRNA levels as well as Fkpb4 mRNA levels in mouse corticotroph cells. Dexamethasone tended to decrease Fkbp4 protein levels, while it increased Fkpb5 mRNA and its protein levels. The dexamethasone-induced decreases in Pomc mRNA levels were partially canceled by Fkbp4 knockdown. Alternatively, Pomc mRNA levels were further decreased by Fkbp5 knockdown. Thus, Fkbp4 contributes to the negative feedback of glucocorticoids, and Fkbp5 reduces the efficiency of the glucocorticoid effect on Pomc gene expression in pituitary corticotroph cells. 相似文献
53.
A numerical method to achieve the simultaneous computation of the seepage flows in porous media and the Navier-Stokes flows in the domain occupied purely by a fluid is presented in this paper. The method uses the Darcy-Brinkman equations with the continuous modelling of the interfacial flow velocity, and applies the finite volume method to the spatial discretization and the fractional step method to the numerical simulation of the incompressible fluid. The coupling of the two different flows is realized by the relevant interpolation of the pressure and the flow velocity onto the interface at which permeability and porosity are discontinuous. The interpolation schemes provide simple solutions to overcome the computational instability caused by the discontinuous change in permeability and to avoid having to resolve the considerably thin transition zone near the interface. Numerical analyses of the one-dimensional uniform flow, the lid-driven cavity flow, and the pipe-flow in a porous medium have been carried out. The results have shown that the proposed schemes enable a stable computation and fulfill the accurate and physically realistic numerical solutions. 相似文献
54.
Kazunori Asano 《International Journal of Cast Metals Research》2018,31(1):29-36
Pure aluminium and high-silicon aluminium alloy were reinforced with the discontinuous pitch-based carbon fibres by squeeze casting, then the thermal conductivity and the mechanical properties of the composites were investigated. Optical microscopy revealed that the fibres were in a random planar arrangement, and the transmission electron microscopy revealed that there is no interfacial reaction between the matrices and the fibres. The random planar arrangement of the fibres leads to the anisotropy of the composite. The fibre-reinforcement increased the thermal conductivity in the parallel direction for both pure aluminium and its alloy matrices, while the thermal conductivity decreased in the vertical direction. The increase in the elastic modulus by the reinforcement was not observed for both matrices. The proof stress of the pure aluminium increased by the reinforcement especially in the parallel direction, while that of the high-silicon alloy decreased by the reinforcement. 相似文献
55.
56.
Kyoko Kofuji Yuzhou Huang Kazufumi Tsubaki Fumihiko Kokido Kazunori Nishikawa Takashi Isobe Yoshifumi Murata 《Reactive and Functional Polymers》2010,70(10):784-789
A transparent wound dressing sheet was obtained by forming a complex between β-glucan and chitosan (CS). These materials were chosen for their biocompatible, bioabsorbable, and biodegradable properties, and they were expected to promote the therapeutic efficacy of the dressing by increasing the wound healing response. The therapeutic efficacy of the β-glucan–CS complex sheet as a wound dressing was evaluated in wounds created on the dorsal surfaces of mice. β-glucan–CS complex sheets demonstrated therapeutic efficacies comparable or superior to that of Beschitin®W, a commercial wound dressing made from CS. Additionally, the β-glucan–CS complex sheet did not dissolve during the application period, did not adhere to wounds, and was easy to remove. Cumulatively, these results indicate that β-glucan–CS complex sheets are a promising new wound dressing product. 相似文献
57.
Hideaki Fujita Kazunori ShimizuYuki Morioka Eiji Nagamori 《Journal of Bioscience and Bioengineering》2010,110(3):359-362
We have studied the effect of enhanced oxygen delivery by perfluorocarbons on the differentiation of C2C12 cells. The extent of differentiation was assessed by means of phase contrast/fluorescence microscopy, active tension measurement and the glucose consumption/lactate production rates. We found that enhanced oxygen delivery is suitable for full differentiation of C2C12 cells. 相似文献
58.
59.
The thermal conductivity of the surface layer of engineering materials changes in the early stages of material degradation due to the appearance of micro‐cracks. A new method for evaluating and assessing the degree of degradation of a material using this change is proposed herein. The influence of the micro‐cracked layer on the temperature response as measured by a thermophysical handy tester was theoretically examined. By defining a thermal degradation parameter, the amount of degradation of various materials was evaluated. In order to verify this theory, fatigue tests using metallic materials were conducted. Comparisons before and after the fatigue tests were then made to establish the correlation between the density of micro‐cracks and the decrease in thermal conductivity. As a result, it was ascertained that a thermal degradation parameter can easily be estimated from a temperature response curve obtained using the tester. © 2007 Wiley Periodicals, Inc. Heat Trans Asian Res, 36(8): 501–512, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/htj.20178 相似文献
60.
日本新建筑标准的结构抗火设计 总被引:4,自引:0,他引:4
KazunoriHarada 《建筑钢结构进展》2003,5(2):46-56
本的目的是为了说明1998—2000期间日本建筑规程(日本建筑标准)以及相关技术标准的修订。考虑了功能要求后,规程修订趋向于以性能为主。在抗大这一章节中,功能要求指的是在发生火灾时防止结构倒塌以及火势向其他隔问的蔓延,同时还包括防止火势由失火建筑物内部向周围建筑的扩散。为了满足功能上的要求,我们提供了三种方法(A、B、C)。方法A是传统的设计方法,即建筑框架及隔墙采用防火构件。相对于方法A,新近引进了以考虑性能为主的方法B。在方法B中,由一系列设计公式计算出指定部分发生火灾可能产生的后果、结构和边界部分的热反应、构件破坏的临界时间。设计公式应足够简单,以便于建筑工程师和有关官员的使用。由方法B计算出的结果通常是保守的。方法C是一个框架,用最先进的设计方法。规程没有指定采用的设计方法,但是工程上火灾和结构分析的结果只有在全面地考证后才能被行业接受。 相似文献