基于状态监测的刀具管控一体化系统

针对刀具管理与刀具监控相互脱节的问题,创建了集成状态监测、故障诊断、刀具管理的刀具管控一体化系统平台,详细分析了系统的功能并提出了系统实现的关键技术。     

聚合物乳液粒子制备纳米多孔增透膜

采用提拉法在载玻片上沉积了PMMA/PS混合乳液粒子,用环己烷选择性地溶解掉表层PS粒子,制备了孔隙率从表向里梯度变化的纳米粒子增透膜,在578 nm处透过率可达99.5%;研究了两种聚合物纳米粒子的比例及环己烷浸泡时间对增透性能的影响。本方法可用于大面积和不规则基材上制备增透膜,并解决了提拉法成膜的粒子堆积紧密、孔隙率低且不易调节的缺点,使粒子膜的透过率大幅度提高。     

Advances in the Therapeutic Effects of Apoptotic Bodies on Systemic Diseases

Apoptosis plays an important role in development and in the maintenance of homeostasis. Apoptotic bodies (ApoBDs) are specifically generated from apoptotic cells and can contain a large variety of biological molecules, which are of great significance in intercellular communications and the regulation of phagocytes. Emerging evidence in recent years has shown that ApoBDs are essential for maintaining homeostasis, including systemic bone density and immune regulation as well as tissue regeneration. Moreover, studies have revealed the therapeutic effects of ApoBDs on systemic diseases, including cancer, atherosclerosis, diabetes, hepatic fibrosis, and wound healing, which can be used to treat potential targets. This review summarizes current research on the generation, application, and reconstruction of ApoBDs regarding their functions in cellular regulation and on systemic diseases, providing strong evidence and therapeutic strategies for further insights into related diseases.     

板坯连铸结晶器铜板热机耦合应力分析

通过对大板坯连铸结晶器铜板热电偶的实测温度数据的分析,获得了铜板温度场分布的基本规律,在考虑钢水、铸坯、铜板以及接触面介质的物理参数随温度变化的前提下,依托有限元软件ANSYS对结晶器铜板的动态温度场、耦合应力场进行动态仿真,获得了铜板在三排热电偶高度上的温度分布与耦合应力应变规律,研究结果为了解铜板的应力/变形情况以及铸坯缺陷分析提供了较好的数据参考.     

Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1–Bcl6 and NF-κB Signaling Pathways and Enhancing Osteoclast Apoptosis

Osteoporosis is a common bone disease, particularly in menopausal women. Herein, we screened four Kampo medicines (Unkeito (UKT), Kamishoyosan (KSS), Kamikihito (KKT), and Ninjinyoeito (NYT)), frequently used to treat menopausal syndromes, for their effects on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation in RAW 264 cells. Considering that UKT exhibited the most potent effect, we examined its effect on RANKL-induced osteoclastogenesis, the induction of osteoclast apoptosis, and the mechanisms underlying its effects. UKT inhibits RANKL-induced osteoclast differentiation in the early stage and decreases osteoclast-related genes, including tartrate-resistant acid phosphatase (Trap), dendritic cell-specific transmembrane protein (Dcstamp), matrix metalloproteinase-9 (Mmp9), and cathepsin K (Ctsk). Specifically, UKT inhibits the nuclear factor of activated T cells 1 (NFATc1), which is essential for osteoclastogenesis. UKT increases Bcl6, which antagonizes NFATc1 and Dc-stamp, thereby blocking the progression of osteoclasts to maturation. UKT also decreased nuclear translocation by downregulating the activity of p65/NF-κB. In addition, UKT enhances mononuclear osteoclast apoptosis via activation of caspase-3. Herein, we demonstrate that UKT suppresses RANKL-mediated osteoclastogenesis via the Blimp1–Bcl6 and NF-κB signaling pathways and enhances mononuclear osteoclast apoptosis. Furthermore, UKT prevents bone loss in OVX mice. Thus, UKT might be a potential therapeutic agent for postmenopausal osteoporosis.     

可调谐单纵模光纤激光器模式特性研究

为了实现光纤激光的单纵模,提出了一种环形腔结构,采用可调谐光纤Bragg光栅(FBG)作为波长选择器件,与2 m未抽运掺Er光纤(EDF)产生驻波饱和效应,在1.55 μm波长处形成42 nm激光输出,输出功率大于3.5 dBm,功率稳定性优于±0.005 dB.扫描Fabry-Porot(F-P)干涉仪观测到2个正交的偏振模,在环形腔内加入偏振器后可抑制强度较低的偏振模式,测量到清晰的单纵模激光,纵模线宽为20 MHz.由于饱和吸收效应,导致了激光输出斜率曲线表现出光学双稳态现象.     

聚硅酸复合絮凝剂的结构和絮凝机理研究

介绍了聚硅酸复合絮凝剂的结构并采用x光衍射分析方法和透射电镜对其形态和絮凝机理进行了分析.结果表明,该絮凝剂具有很好的稳定性和较佳的处理效果,是一种较PAC、PFC更加优良的絮凝剂.     

砂泥岩互层裂缝发育的地层厚度效应

为了研究砂泥岩互层型地层的厚度效应对裂缝发育的影响,塔里木盆地库车坳陷克深气田辫状河三角洲前缘砂泥岩互层型储集层为例,分析了裂缝发育机制,应用数值模拟方法计算了不同厚度砂泥岩互层型地层裂缝的密度、开度和孔隙度,提出了6种砂泥岩组合的裂缝发育模式。数值模拟结果显示,砂岩、泥岩单层厚度越薄,越容易产生裂缝,砂泥岩互层型地层裂缝发育还受到岩层厚度的影响。在相同应力条件下,中、厚层（1.5~10.0 m）砂岩可以产生开度大和延伸长的裂缝,裂缝能够延伸至或刺穿泥岩层;薄层（小于1.5 m）砂岩裂缝规模小,对泥岩影响较弱。泥岩厚度相同时,与其组合的砂岩厚度越大,泥岩越容易产生裂缝。当泥岩厚度小于1.0 m时,泥岩受力后自身就容易破裂而产生裂缝。在构造变形相似的区域,辫状河三角洲前缘水下分流河道裂缝孔隙度高,连通性好,可以形成良好的储集层;其次为河口坝;远砂坝和席状砂以及水下分流河道间砂体裂缝孔隙度较低,且裂缝连通性差,难以成为有利储集层。泥岩厚度大于1.0 m且与泥岩组合的砂岩厚度小于5.5 m时,可以成为隔夹层,对油气起到封隔作用。     

砂砾岩稠油油藏蒸汽驱数值模拟研究

对砂砾岩稠油油藏进行注蒸汽热力采油，在吞吐阶段历史拟合、汽驱阶段跟踪拟合的基础上，进行方案优选。确定该类型油藏吞吐７～８周期为最佳转驱时机；汽驱阶段最佳注汽速度为６～８ｔ／ｈ；汽驱阶段边角井蒸汽引效能实现较好的开发效果；采用略大于１．０的采注比，按最优方案生产，汽驱阶段采出程度为１７％～１８％。     

马来酸酐-丙烯酸十八醇酯-醋酸乙烯酯三元共聚物柴油降凝剂的合成及其性能评价

实验以马来酸酐(MA)、丙烯酸十八醇酯(AE)、醋酸乙烯酯(VA)为原料,合成三元聚合物MAV。考察了MAV的最佳反应条件及其对柴油的降滤效果,分析了4种不同柴油正构烷烃碳数分布,测试了MAV对4种不同柴油的降滤效果,红外光谱(IR)表征了AE单体及MAV共聚物。实验结果表明,MAV三元聚合物的最佳合成条件为:n(马来酸酐):n(丙烯酸十八醇酯):n(醋酸乙烯酯)=1:1:1,聚合温度为80℃,聚合时间为4 h,引发剂用量为1.0%。MAV对四种不同柴油的降滤效果不同,对加氢柴油有较好的适用性,对直馏柴油和催化裂化柴油的降滤效果较差。当加剂量为0.3%时,可将燕化加氢柴油的冷滤点降低3℃。MAV柴油降凝剂对正构烷烃分布较宽且含量低的柴油感受性较好,对正构烷烃分布窄且含量高,特别是高碳数正构烷烃含量较高的柴油几乎无降滤效果。