Comprehensive Analysis of Oligo/Polysialylglycoconjugates in Cancer Cell Lines

In cancer cells, cell-surface sialylation is altered, including a change in oligo/polysialic acid (oligo/polySia) structures. Since they are unique and rarely expressed in normal cells, oligo/polySia structures may serve as promising novel biomarkers and targets for therapies. For the diagnosis and treatment of the disease, a precise understanding of the oligo/polySia structures in cancer cells is necessary. In this study, flow cytometric analysis and gene expression datasets were obtained from sixteen different cancer cell lines. These datasets demonstrated the ability to predict glycan structures and their sialylation status. Our results also revealed that sialylation patterns are unique to each cancer cell line. Thus, we can suggest promising combinations of antibody and cancer cell for glycan prediction. However, the precise prediction of minor glycans need to be further explored.     

Fractals from simple polynomial composite functions

This paper describes a method of generating fractals by composing two simple polynomial functions. Many common fractals, such as the Mandelbrot set, the tricorn, and the forced logistic map, as well as new fractals can be generated with this technique. In many cases, the symmetry of the resulting fractal can be easily proved.     

循环函数法在回热系统中的局部定量计算

根据等效焓降法在热力系统计算时的特点,推导了循环函数法在回热系统中的局部定量计算方法,导出了回热系统局部定量计算的几个重要结论.最后,通过实例计算对所得结论进行了验证.验证结果表明,该方法在回热系统局部定量计算过程中具有简洁、准确、概念清晰等特点,适合推广.     

成本时间限制下的网格分类调度算法研究

在网格环境中,由于资源广域分布、异构、动态且有多个管理域,调度一组具有多QoS需求如成本、时间的独立任务是一个非常重要的问题。针对网格任务的成本和执行时间要求,提出了一种基于网格经济模型,根据实际执行成本和预算成本进行分类的网格分类优化调度算法。模拟实际网格任务调度实验表明,该算法能很好地满足网格环境中不同用户的需求。     

预张力值对郑州会展中心斜拉结构的稳定性能影响分析

郑州国际会展中心钢屋盖采用空间斜拉式张弦桁架结构,预张力的施加成为影响结构稳定性能的主要因素之一。以其钢屋盖的一个矩形单元为算例,借助ANSYS分析软件,模拟结构的初始状态进行分析。在自重和预张力作用下,对下悬张拉索分别施加不同大小的预张力,从0 kN到1 500 kN共计18种,研究预张力值变化与结构稳定安全系数以及屈曲模态变化所呈现出的关系。结果表明,预张力值对结构稳定性能的影响趋于复杂化和无规律化。建议在预张力施加过程中,对于稳定性能的影响评判要兼顾多方面的考虑。为斜拉张弦桁架体系在初始状态下的预张力取值提供了设计依据。     

粗糙平面的激光散射特性研究

为了检测目标的边缘信息,采用激光扫描目标表面、通过回波信号变化来得到目标的边缘信息的方法,利用随机面元模型,分析了刚性随机粗糙平面的激光散射特点,建立了实用化的随机粗糙平面激光散射理论模型,并给出了正入射时几种情况下的激光散射图像,分析了平面目标的激光散射能量计算方法,仿真了光束在平面目标表面做正弦摆动时,光斑在不同位置的反射能量,利用激光信号的强度变化,采用峰(谷)检出法或者过零检出法就可以得到物体的边缘信息。结果表明,通过回波信号的变化,可以得到目标的边缘轮廓。     

Balancing the corrosion resistance and through-plane electrical conductivity of Cr coating via oxygen plasma treatment

Developing an electrically conductive and corrosion-resistant coating is essential for metal bipolar plates of polymer electrolyte membrane fuel cells(PEMFCs). Although enhanced corrosion resistance was seen for Cr coated stainless steel(Cr/SS) bipolar plates, they experience a quick decrease of through-plane electrical conductivity due to the formation of a porous and low-conductive corrosion product layer at the plate surface, thus leading to an increase in interfacial contact resistance(ICR). To tackle this issue, the multilayer Cr coatings were deposited using the magnetron sputtering with a remote inductively coupled oxygen plasma(O-ICP) in the present study. After the O-ICP treatment, a Cr oxide layer(Cr O*) is formed on the specimen surface. The Cr O*/Cr/SS has a remarkably lower stable corrosion rate(iss) than that of the native Cr oxides(Cr On/Cr/SS). Compared with Cr On/Cr/SS, the excellent performance of Cr O*/Cr/SS is attributed to a denser and thicker surface layer of Cr O* with Cr being oxidized to its highest valence state,Cr(VI). More importantly, the through-plane electrical conductivity of the specimens treated by the optimized O-ICP decreases much slowly than Cr On/Cr/SS and thus, the increament of ICR of Cr O*/Cr/SS after the potentiostatic polarization test is considerably smaller than that of Cr On/Cr/SS, which is benefited from the reduced issthat mitigates the deposition of corrosion products and hinders further oxidation of Cr coating. Therefore, Cr O*/Cr/SS proves to be a well balanced trade-off between corrosion resistance and through-plane electrical conductivity. The results of this study demonstrate that O-ICP treatment on a conductive metal coating is an effective strategy to improve the corrosion resistance and suppress the increase of ICR over the long-term polarization. The technique reported herein exhibits its promising potential application in preparing corrosion resistant and electrically conductive coatings on metal bipolar plates to be used in PEMFCs.     

Example Based Everyting

The magic of computer graphics as seen in many current movies and computer games comes at a cost. Creating the geometric forms with which to generate synthetic characters and animating the characters to bring them to life require either highly skilled artists and/or sophisticated capture devices. Both are expensive and, in the case of highly skilled artists, rare.     

Discovery of functional protein groups by clustering community links and integration of ontological knowledge

In this paper we cluster data from protein networks and integrate the results with chemical databases and ontologies to investigate functional links between related disease states. It is well know that certain genes participate in more than one function and if they are defective are likely to be responsible for several health problems. Furthermore, genes tend to cooperate in associated networks or cascades often with ’crosstalk’ between networks which can subtly alter cellular functions. Understanding the complexity and role of the various cell functions and mechanisms requires the use of computational models to make inferences and link together the interplay between genes, proteins and chemical interactions. A deeper understanding of the mechanisms of diseases will eventually be of benefit for the development new and improved therapies. The particular disease state we investigate in this work is cystinosis which is characterized by the widespread deposition of the amino acid cystine in cells due to a defect in cystine transport. In cystinosis, cystine accumulates in the lysosomes and eventually forms crystals throughout the body causing problems in the kidneys and the eyes. The defect is caused by a mutation in the CTNS gene and this forms the starting point for our investigation.