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排序方式: 共有540条查询结果,搜索用时 15 毫秒
71.
Hitoshi Kakimoto Takehiro Hayashi Hirosi Handa Kenzi Yukihira Yukio Okamura Naotaka Odaka 《Electrical Engineering in Japan》1995,115(5):75-87
This paper describes the development of the Automatic Fault Point Locating and Sectional Isolating System. This system locates a single-line-to-ground fault point at each pole by using ground-current sensors, and isolates the faulted section by controlling pole switches with no outage of unfaulted sections. The ground-current sensor is connected to the line between allied ground terminals of pole devices and grounded conductor. It detects a ground fault current of more than 0.64 amperes that is determined so as to avoid an unexpected operation by stray current, but to detect the fault current accurately, and sends out an emergency signal with time delay of 0.1 s. Sectional isolation starts when both the emergency signal from the sensor and relay operation signals from a substation are received and ends within a feeder circuit-breaker tripping time of 1.5 s. 相似文献
72.
Two studies examined the effects of an apology on a victim's aggression and explored the psychological mechanisms underlying such effects. In Study 1, female undergraduates were psychologically harmed and then received an apology by another female student. In Study 2, male undergraduates were asked to role play a victim in a hypothetical harm situation. Results indicate that when the harm-doers apologized, as opposed to when they did not, the victim-subjects refrained from severe aggression against them. Regression analyses suggested that such aggression-inhibitory effects of an apology were mediated by impression improvement, emotional mitigation, and reduction in desire for an apology within the victims. It was also found that when the harm was severe, such effects of an apology on aggression were attenuated. The more severe the harm is, the more extensive of an apology may be needed to alleviate the victim's anger and aggression. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
73.
74.
A series (C1-C12) of alkyl gallates was examined for their effects on the activity of xanthine oxidase. Octyl (C8), decyl (C10), and dodecyl (C12) gallates competitively inhibited uric acid formation generated by xanthine oxidase, and the inhibition increased upon increasing the alkyl chain length. Interestingly, neither menthyl nor bornyl gallates inhibited uric acid formation. These data indicate that the hydrophobic alkyl portion is associated with the xanthine-binding site in the Mo-binding domain. It is likely that the linear alkyl portion interacts with the hydrophobic domain close to the binding site, and the hydrophobic interaction is crucial to inhibit the xanthine oxidase reaction. On the other hand, all of gallic acid and its esters equally suppress superoxide anion generation catalyzed by xanthine oxidase at low concentration. The suppression is not due to scavenging activity of these gallates but due to reduction of xanthine oxidase by these gallates. The reduced enzyme catalyzes the reaction to generate hydrogen peroxide and uric acid. 相似文献
75.
Kurokawa M Sato K Smyth J Wu H Fukami K Takenawa T Fissore RA 《Reproduction (Cambridge, England)》2004,127(4):441-454
Recent evidence in marine invertebrate, frog, and zebrafish eggs suggests the involvement of a Src family kinase (SFK) in fertilization-induced Ca2+ release. In the present study, we have investigated whether activation of an SFK is required for initiation of intracellular Ca2+ ([Ca2+]i) oscillations in mouse fertilization. We detected a Hck-like protein and tyrosine-phosphorylated proteins in soluble and insoluble sperm fractions, respectively. However, the presence of these proteins did not correspond to the active fractions of porcine sperm extracts (pSE). Moreover, [Ca2+]i oscillations induced by pSE in mouse eggs were unaltered by pre-incubation of pSE with specific SFK inhibitors such as 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazol[3,4-d]-pyrimidine (PP2) or lavendustin A, despite the fact that the inhibitors were shown to be active both in vivo and in vitro. Another SFK inhibitor, peptide A, blocked oscillations when incubated with pSE prior to injection into eggs, but this inhibition required more than ten times the concentration reportedly required to inhibit SFK activity. In addition, pre-injection or pre-incubation of eggs with these inhibitors did not affect the ability of pSE to trigger [Ca2+]i oscillations in mouse eggs. Microinjection of a recombinant c-Src protein or mRNAs encoding constitutively active Src proteins did not induce [Ca2+]i release. Finally, when sperm and eggs, both of which were pre-treated with PP2, were fertilized, [Ca2+]i oscillations occurred normally. We can therefore conclude that activation of an SFK is neither necessary nor sufficient for triggering fertilization-induced [Ca2+]i oscillations. 相似文献
76.
Two kinds of aromatic–aliphatic polyamide oligomers were newly prepared by the reactant pairs of 3,4′-oxydianiline–adipic acid and 3,4′-oxydianiline–azelaic acid. These oligomers were then condensed separately with α, ω-polybutadienedicarboxylic acid giving two series of polybutadiene–polyamide multiblock copolymers. Properties of four series of polybutadiene–polyamide multiblock copolymers, whose polyamide blocks consisted of not only newly prepared polyamides but also previously synthesized aromatic polyamides derived from 4,4′-oxydianiline–isophthalic acid and 3,4′-oxydianiline–isophthalic acid, were investigated on the view point of structure-property relationship. A larger extent of the Tg depression of polybutadiene phase, and higher tensile strength and modulus were observed in the block copolymers having aromatic polyamides compared with those having aliphatic ones. 相似文献
77.
Human placenta gangliosides 总被引:2,自引:0,他引:2
Takao Taki Ken-ichi Matsuo Kaname Yamamoto Toshiko Matsubara Akira Hayashi Tadayuki Abe Makoto Matsumoto 《Lipids》1988,23(3):192-198
Gangliosides extracted from human placenta were composed of four major components (G1–G4), which were purified by silica beads
column chromatography. The structures of these gangliosides were analyzed by exoglycosidase treatments, 400 MHz proton magnetic
resonance spectroscopy and gas chromatography-mass spectrometry and were concluded to be as follows:
Gangliosides containing more than 10 sugar residues were observed in addition to the above four major components. But ganglio-series
gngliosides were undetectable in the placenta. 相似文献
78.
Summary Plasma-polymerized membranes for gas separation were prepared from 1-(trimethylsilyl)-1-propyne. The permeation data of He, H2 02, N2, CO2, and CH4 through the membranes showed plasma-polymerized 1-(trimethylsilyl)-1-propyne had high permselectivity but low permeability compared with poly[l-(trimethylsilyl)-1-propyne]. This behavior is considered to be due to the crosslinking structure of the plasma-polymerized membrane. The correlation between plasma polymerization conditions and the membrane performance was studied. The optimum condition at which the deposition rate of the plasma polymer is maximized agreed with the optimum value to yield maximum separation factor of gases through the membrane. 相似文献
79.
Hakoshima Toshio; Toda Shoji; Sugio Shigetoshi; Tomita Ken-ichi; Nishikawa Satoshi; Morioka Hiroshi; Fuchimura Kayoko; Kimura Tsuyoshi; Uesugi Sei-ichi; Ohtsuka Eiko; Ikehara Morio 《Protein engineering, design & selection : PEDS》1988,2(1):55-61
Recognition by ribonuclease T1 of guanine bases via multidentatehydrogen bonding and stacking interactions appears to be mediatedmainly by a short peptide segment formed by one stretch of aheptapeptide, Tyr42-Asn43-Asn44-Tyr45-Gly46-Gly47-Phe48. Thesegment displays a unique folding of the polypeptide chainconsistingof a reverse turn, Asn44-Tyr45-Glu46-Gly47, stabilized by ahydrogen-bond network involving the side chain of Asn44, themain-chain atoms of Asn44, Gly47 and Phe48 and one water molecule.The segment is connected to the C terminus of a ß-strandand expands into a loop region between Asn43 and Ser54. Lowvalues for the crystallographic thermal parameters of the segmentindicate that the structure has a rigidity comparable to thatof a ß-pleated sheet. Replacement of Asn44 with alanineleads to a far lower enzymatic activity and demonstrates thatthe side chain of Asn44 plays a key role in polypeptide foldingin addition to a role in maintaining the segment structure.Substitution of Asn43 by alanine to remove a weak hydrogen bondto the guanine base destabilized the transition state of thecomplex by 6.3 kJ/mol at 37°C. In contrast, mutation ofGlu46 to alanine to remove a strong hydrogen bond to the guaninebase caused a destabilization of the complex by 14.0 kJ/mol.A double-mutant enzyme with substitutions of Asn43 by a histidineand Asn44 by an aspartic acid, to reproduce the natural substitutionsfound in ribonuclease Ms, showed an activity and base specificitysimilar to that of the wild-type ribonuclease Ms. The segmenttherefore appears to be well conserved in several fungal ribonucleases. 相似文献
80.
Masaki Tsuji Seiji Isoda Masayoshi Ohara Akiyoshi Kawaguchi Ken-ichi Katayama 《Polymer》1982,23(11):1568-1574
Individual chains comprising a β-form poly(p-xylylene) (PPX) single crystal were resolved with a high resolution electron microscope (JEM-500). In a polymer crystal the important limiting factor for resolution is radiation damage. The total end point dose of a PPX crystal is about 0.5 coulomb cm?2 for 500 kV electron irradiation which is more than 20 times greater than that for a polyethylene crystal. The high resolution image obtained was processed by optical filtering to reduce noise due to the granularity of film. The processed image, which corresponds to the ab-plane projection of polymer chains, shows clearly the mutual arrangement of each molecule in the crystal. This high resolution image is sufficient to provide a starting point for determining the unknown crystal structure of the β-modification of PPX. 相似文献