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排序方式: 共有801条查询结果,搜索用时 0 毫秒
81.
82.
Terutsugu Koya Yo Niida Misa Togi Kenichi Yoshida Takuya Sakamoto Hiroki Ura Sumihito Togi Tomohisa Kato Jr. Sohsuke Yamada Haruo Sugiyama Shigeo Koido Shigetaka Shimodaira 《International journal of molecular sciences》2022,23(20)
Malignant pleural effusion (MPE) provides a liquid tumor microenvironment model that includes cancer cells and immune cells. However, the characteristics of tumor antigen-specific CD8+ T cells have not been investigated in detail. Here, we analyzed MPE samples taken from a patient with pancreatic cancer who received a dendritic cell vaccine targeting Wilms’ Tumor 1 (WT1) antigen over the disease course (two points at MPE1st and 2nd, two months after MPE1st). Epithelial cell adhesion molecule (EpCAM)+ cancer cells (PD-L1− or T cell immunoglobulin mucin-3, TIM-3−), both PD-1 or TIM-3 positive CD8+ T cells, and CD14+CD68+CD163+TIM-3+ macrophages increased from the MPE1st to MPE2nd. The ratio of WT1-specific cytotoxic lymphocytes (WT1-CTLs) to MPE CD8+ T cells and IFN-γ secretion of WT1-CTLs were reduced with disease progression. Coincidentally, the fraction of central memory T (TCM) of WT1-CTLs was decreased. On the other hand, CD8+ T cells in response to SMAD4P130L, which is homogeneously expressed in EpCAM+ cancer cells, were detected using in vitro expansion with the HLA-A*11:01 restrictive SVCVNLYH neoantigen. Furthermore, the CD8+ T cell response to SMAD4P130L was diminished following remarkably decreased numbers of CD8+ TCM in MPE samples. In conclusion, CD8+ T cells responding to WT1 or SMAD4P130L neoantigen expressed in EpCAM+ pancreatic cancer cells were detected in MPE. A tumor antigen-specific immune response would provide novel insight into the MPE microenvironment. 相似文献
83.
Hideki Harano Kenichi Kinoshita Koji Yoshii Toru Ueda Shunsuke Okita Mitsuru Uesaka 《Journal of Nuclear Materials》2000,280(3):255-263
As a promising tool for ultrafast material analyses, we propose to utilize the X-ray pulse which may be generated in a quite simple manner using subpicosecond electron linacs. The properties of the X-ray were numerically studied with the EGS4 code. Verification of the X-ray generation was also conducted at the Nuclear Engineering Research Laboratory (NERL) linac and clear diffraction patterns of characteristic X-ray were obtained for typical single crystals. 相似文献
84.
In recent years the requirement for the reduction of energy consumption has been increasing to solve the problems of global warming and the shortage of petroleum resources. For example, in the power generation field, as thermal power generation occupied 60% of the power generation demand, considerable improvement of the thermal efficiency is required. This paper describes the pressure drop characteristics of finned tube banks used for heat exchangers in thermal power generation that were clarified by testing serrated finned tube banks with different fin heights for improved heat transfer and conventional spiral finned tube banks with different fin heights, and an equation to predict pressure drop which is necessary for the heat exchanger design is proposed. © 2006 Wiley Periodicals, Inc. Heat Trans Asian Res, 35(3): 179–193, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/htj.20112 相似文献
85.
Solving fuzzy shortest path problems by neural networks 总被引:1,自引:0,他引:1
In this paper, we introduce the neural networks for solving fuzzy shortest path problems. The penalization of the neural networks is realized after transforming into crisp shortest path model. The procedure and efficiency of this approach are shown with numerical simulations. 相似文献
86.
This paper describes realtime network management support systems which have been developed forntt’s telephone network. In particular, the advanced traffic observation and management information collecting system referred to as Atomics and the traffic congestion control system referred to astcs are presented. The purpose of the development, concept, functions and capabilities of each system are explained. Examples of powerful realtime network management supported by Atomics andTSC are also presented. 相似文献
87.
The slip systems of diacetylene (PTS) monomer crystals which were deformed with a shear deformation and a micro indentation
were determined. The (1 0 0) [0 0 1], (1 0 0) [0 1 0] and (1 0 2) [0 1 0] slip systems eventually were identified as the main
slip systems from the stress-strain curves, slip lines and etch-pit arrangements. 相似文献
88.
Experiments using partial report techniques have typically failed to find left-right visual field differences in the recognition of tachistoscopically presented letter rows. Such data represent a difficulty for theories that emphasize the relevance of cerebral hemispheric asymmetry. It is contended that the end items of a display are critical, and that a truly symmetric display should have both a left and a right end item in each visual field. In the present experiments with 36 righthanded university students, partial report procedures were employed, but a gap was placed between the left and right halves of the display. In the 1st experiment, a single-letter spatial probe procedure was used, and a clear right visual field superiority was found. In the 2nd experiment, a hemifield report procedure was used; the presence of a gap in the display enhanced the right visual field superiority, especially for shorter strings of letters. Results indicate that right visual field superiority can be obtained with partial report procedures under appropriate conditions. (French summary) (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
89.
Photoelectrochemical investigations were undertaken on energy transfer and other interactions between chlorophyll-a (Chl-a) and β-carotene (Car) in lipid monolayers. A heterobilayer composed of a Chl-a-lecithin monolayer and a Car- lecithin monolayer was prepared on an SnO2 semiconductor electrode by Langmuir-Blodgett techniques. When the bilayer-coated electrode was irradiated in an aqueous electrolyte, anodic photocurrents due to the sensitizations by Chl-a and Car respectively were observed. The photocurrent efficiency (ratio of photons to electrons) was much for Car (about 10-3) than for Chl-a (about 10-1). This large difference permits a quantitative estimation of the energy transfer from Car to Chl-a, based on the concept that the energy transfer results in an increase in the Car- induced sensitized photocurrent. The effect of added Chl-a on the Car photocurrent was measured for heterobilayers with various Chl-a-to-Car molar ratios. The experimental results, as well as theoretical calculations, showed that the Car-to- Chl-a energy transfer is inefficient. The effect of Car on the Chl-a-sensitized photocurrent was also studied with the same bilayer system. The effect was shown to be complex depending on the Car content. A lowering of the Chl-a photocurrent occurred at high Car contents, which is considered to reflect the quenching of the Chl-a excited triplet by Car. The usefulness of the present photoelectrochemical approach for the study of energy transfer between the photosynthetic pigments is demonstrated. 相似文献
90.