Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus

Advanced glycosylation end products (AGEs) accumulate on long-lived extracellular matrix proteins and have been implicated in the micro- and macrovascular complications of diabetes mellitus. Within the arterial wall, AGE-modified proteins increase vascular permeability, inactivate nitric oxide activity, and induce the release of growth-promoting cytokines. Recently developed anti-AGE antibodies were used in an immunohistochemical analysis of coronary arteries obtained from type II diabetic and nondiabetic patients. High levels of AGE reactivity were observed within the atherosclerotic plaque present in vessels from selected patients with diabetes. Considered together with the pathological effects of AGEs on vascular wall homeostasis, these data support the role of advanced glycosylation in the rapidly progressive atherosclerosis associated with diabetes mellitus.     

Heat Generation in Multilayer Piezoelectric Actuators

Multilayer piezoelectric actuators when driven under high frequency, generate significant heat, which influences the reliability and other piezoelectric properties. In this paper, heat generation in various types of multilayer PZT-based actuators was studied. Experimental results showed that heat generation is mainly caused by ferroelectric hysteresis loss in the stress-free state. A simplified analytic method was established to evaluate the temperature rise, which is useful for the design of multilayer and other high-power actuators.     

Discharge behaviour of electrodeposited PbO2 and Pb electrodes

The discharge behaviour of electrodeposited lead dioxide and lead electrodes was investigated under various conditions; the surfaces of the discharged electrodes were observed with a scanning electron microscope. Both the positive and negative electrodes were passivated by a covering of deposited lead sulphate crystals. The amount of lead sulphate required for passivation depended on the size of the crystals.     

Band Gaps of Na2C60 and K4C60

respectively.     

Bottom-up multi-agent reinforcement learning by reward shaping for cooperative-competitive tasks

Applied Intelligence - A multi-agent system (MAS) is expected to be applied to various real-world problems where a single agent cannot accomplish given tasks. Due to the inherent complexity in the...     

Development of a dual‐lamp projector with higher brightness

Stationary projectors mainly used in system applications have recently gained a wider application range, including general presentations in halls and large conference rooms and being used, for example, in digital signage and for monitoring purposes. Consequently, they are required to meet new market demands for durability, reliability, and flexibility in installation in addition to their conventional basic performance such as especially high brightness. To achieve especially high brightness, a new optical system with two lamps is proposed; the profile of the cover glass that prevents the glass from scattering is made aspherical, the profile of the beam‐combining mirror is improved with its position optimized, and the size of the incident plane of the integrator rod is made larger (1.1 times). These measures resulted in an optical system of an even higher efficiency with 7000 lm, which is the highest in its class (according to a June 2010 investigation). Also, the arrangement of two parallel lamps completely eliminated the effect of heat passing from one lamp to the other, which helped secure durability, reliability, and flexibility in installation. Furthermore, the combined use of the unique non‐telecentric optical system, adopted from the conventional single‐lamp model, helps maintain the class‐highest contrast ratio.^1,2     

Space–Time and ALE-VMS Techniques for Patient-Specific Cardiovascular Fluid–Structure Interaction Modeling

This is an extensive overview of the core and special space?Ctime and Arbitrary Lagrangian?CEulerian (ALE) techniques developed by the authors?? research teams for patient-specific cardiovascular fluid?Cstructure interaction (FSI) modeling. The core techniques are the ALE-based variational multiscale (ALE-VMS) method, the Deforming-Spatial-Domain/Stabilized Space?CTime formulation, and the stabilized space?Ctime FSI technique. The special techniques include methods for calculating an estimated zero-pressure arterial geometry, prestressing of the blood vessel wall, a special mapping technique for specifying the velocity profile at an inflow boundary with non-circular shape, techniques for using variable arterial wall thickness, mesh generation techniques for building layers of refined fluid mechanics mesh near the arterial walls, a recipe for pre-FSI computations that improve the convergence of the FSI computations, the Sequentially-Coupled Arterial FSI technique and its multiscale versions, techniques for the projection of fluid?Cstructure interface stresses, calculation of the wall shear stress and oscillatory shear index, arterial-surface extraction and boundary condition techniques, and a scaling technique for specifying a more realistic volumetric flow rate. With results from earlier computations, we show how these core and special FSI techniques work in patient-specific cardiovascular simulations.     

Computational Methods for Parachute Fluid–Structure Interactions

The computational challenges posed by fluid–structure interaction (FSI) modeling of parachutes include the lightness of the parachute canopy compared to the air masses involved in the parachute dynamics, in the case of “ringsail” parachutes the geometric complexities created by the construction of the canopy from “rings” and “sails” with hundreds of ring “gaps” and sail “slits”, and in the case of parachute clusters the contact between the parachutes. The Team for Advanced Flow Simulation and Modeling () has successfully addressed these computational challenges with the Stabilized Space–Time FSI (SSTFSI) technique, which was developed and improved over the years by the and serves as the core numerical technology, and a number of special techniques developed in conjunction with the SSTFSI technique. The quasi-direct and direct coupling techniques developed by the , which are applicable to cases with incompatible fluid and structure meshes at the interface, yield more robust algorithms for FSI computations where the structure is light and therefore more sensitive to the variations in the fluid dynamics forces. The special technique used in dealing with the geometric complexities of the rings and sails is the Homogenized Modeling of Geometric Porosity, which was developed and improved in recent years by the . The Surface-Edge-Node Contact Tracking (SENCT) technique was introduced by the as a contact algorithm where the objective is to prevent the structural surfaces from coming closer than a minimum distance in an FSI computation. The recently-introduced conservative version of the SENCT technique is more robust and is now an essential technology in the parachute cluster computations carried out by the . We provide an overview of the core and special techniques developed by the , present single-parachute FSI computations carried out for design-parameter studies, and report FSI computation and dynamical analysis of two-parachute clusters.     

用微机图象法对脉冲MAG焊接熔池进行观察和控制的研究

本文对微机图象法在脉冲MAG焊接中的应用作了探讨,设计和采用了带有CCD摄象机的微机控制系统,对脉冲MAG焊接熔池进行了观察、监控和图象处理。其结果证明了采用微机图象法来实现实时控制是可行的。