Mechanical properties of porous ceramics in compression: On the transition between elastic,brittle, and cellular behavior

This paper deals with the uniaxial compression behavior of porous ceramics within a wide range of porosity, varying from 30 to 75 vol%. The load–displacement curves recorded on porous alumina samples showed a transition between a typical brittle behavior at porosity fractions below 60 vol% and a damageable, cellular-like behavior, at higher porosity fractions. This transition in fracture mode was confirmed by in situ compression tests in an X-ray tomograph. Based on a simple model taking into account the competition between the crack length initiating from spherical pores and the mean distance between pores, the porosity at which the transition took place was estimated. The influence of the pore size also depended on the volume fraction of pores: no size effect was noted at the lowest porosity whereas a statistical effect on the size of the solid walls was observed at higher porosity, with an increase in fracture strength with small pores.     

Study of the effect of prolonged magnetic stirring on the physico-chemical surface properties of nanometric transition alumina

This article reports the study of a transition nanometric alumina both as such and after prolonged magnetic stirring in bi-distilled water. Stirring was effective in inducing a significant reduction of starting particles agglomeration and modification of the surface properties of the material. The formation of an Al(OH)₃ (gibbsite) phase after magnetic stirring in water was detected by means of XRD on powdered samples. Correspondingly, Infra Red spectrum of magnetically stirred alumina outgassed at 150 °C showed a band at ca. 3300 cm⁻¹, ascribable to the hydroxide phase, which decomposes at higher temperature. Differential thermal analysis and thermogravimetry also showed a different thermal behaviour between the two materials, in that magnetically stirred alumina presents a broad endothermic peak at about 280 °C accompanied by an abrupt mass loss (ca. 0.5% of the initial weight), due to dehydration of the hydroxide phase.     

The effect of context on misclassification costs in e-commerce applications

The performance of customer behavior models depends on both the predictive accuracy and the cost of incorrect predictions. Previous research showed that including context in the customer behavior models can improve the accuracy. However, improving accuracy does not necessarily mean that the misclassification cost decreases. In fact, different errors have different costs. Even if the number of incorrect predictions decreases, the number of errors associated with higher costs increase. The aim of this paper is to understand whether including context in a predictive model reduces the misclassification costs and in which conditions this happens. Experimental analyses were done by varying the market granularity, the dependent variable and the context granularity. The results show that context leads to a decrease in the misclassification cost when the unit of analysis is the single customer or the micro-segment. The exceptions may occur when the unit of analysis is a segment. These findings have significant implications for companies that have to decide whether to gather context and how to exploit it best when they build predictive models of the behavior of their customers.     

Analyses of pressure perturbation events in boiling water reactor

In order to design more stable and safer core configurations, experimental and theoretical studies about BWR (Boiling Water Reactor) instability have been performed to characterize the phenomenon and to predict the conditions for its occurrence. The instabilities can be caused by interdependencies between thermal-hydraulic and reactivity feedback parameters such as the void-coefficient, for example, during a pressure perturbation event. In this work, the RELAP5-MOD3.3 thermal-hydraulic system code and the PARCS-2.4 3D neutron kinetic code were coupled to simulate BWR transients. The pressure perturbation is considered in order to study in detail this type of transient. Two different algorithms developed at the University of Pisa were used to calculate the Decay Ratio (DR) and the natural frequency (NF) from the power oscillation signals obtained from the transient calculations. The validation of a code model set up for the Peach Bottom-2 BWR plant is performed against Low-Flow Stability Tests (LFST). The four series of Stability Tests were performed at Peach Bottom Unit 2 in 1977 at the end of cycle 2 in order to measure the reactor core stability margins at the limiting conditions used in design and safety analysis.     

PD-1/PD-L1 Immuno-Mediated Therapy in NAFLD: Advantages and Obstacles in the Treatment of Advanced Disease

Non-alcoholic fatty liver disease (NAFLD) is characterized by an enhanced activation of the immune system, which predispose the evolution to nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Resident macrophages and leukocytes exert a key role in the pathogenesis of NAFLD. In particular, CD4+ effector T cells are activated during the early stages of liver inflammation and are followed by the increase of natural killer T cells and of CD8+ T cytotoxic lymphocytes which contribute to auto-aggressive tissue damage. To counteract T cells activation, programmed cell death 1 (PD-1) and its ligand PDL-1 are exposed respectively on lymphocytes and liver cells’ surface and can be targeted for therapy by using specific monoclonal antibodies, such as of Nivolumab, Pembrolizumab, and Atezolizumab. Despite the combination of Atezolizumab and Bevacizumab has been approved for the treatment of advanced HCC, PD-1/PD-L1 blockage treatment has not been approved for NAFLD and adjuvant immunotherapy does not seem to improve survival of patients with early-stage HCC. In this regard, different ongoing phase III trials are testing the efficacy of anti-PD-1/PD-L1 antibodies in HCC patients as first line therapy and in combination with other treatments. However, in the context of NAFLD, immune checkpoints inhibitors may not improve HCC prognosis, even worse leading to an increase of CD8+PD-1+ T cells and effector cytokines which aggravate liver damage. Here, we will describe the main pathogenetic mechanisms which characterize the immune system involvement in NAFLD discussing advantages and obstacles of anti PD-1/PDL-1 immunotherapy.     

Genotypic and phenotypic heterogeneity in Enterococcus isolates from Batzos, a raw goat milk cheese

This study investigated the genotypic and phenotypic diversity in 34 isolates of enterococci obtained during ripening of Batzos cheese from raw goat milk and characterized phenotypically as Enterococcus durans. RAPD-PCR, plasmid profiling and PFGE were used to study the genetic variability and distinguish closely related isolates. Species recognition by means of RAPD-PCR was in agreement with the phenotypic identification for 29 strains. One strain was characterized as Lactococcus lactis subsp. lactis by RAPD-PCR and four strains were grouped with the Enterococcus faecium reference strain. All strains were vancomycin sensitive, while 10 strains showed beta-haemolytic reaction on human blood and the majority of them (88.9%) showed decarboxylase activity on tyramine. All strains exhibited antagonistic activity against Bacillus cereus, Staphylococcus aureus, Escherichia coli and Listeria monocytogenes and the majority inhibited Enterococcus faecalis. Isolates displayed weak acidifying ability and low proteolytic activities when grown in milk for 24h. However, their caseinolytic activity after growth in milk for seven days was significant with preference for alphas-casein degradation.