共载TPE衍生物和纳米银的PLGA复合载药体系的抑菌活性研究

通过复乳法合成复合纳米载药体系PLGA@TPE@Ag,其粒径大小300 nm左右,分散均一.其载药量达到了35±3.7％,包封率为73±0.9％,具有明显的药物缓释特性.PLGA@TPE@Ag对耐药性的大肠杆菌MIC值是2.3±0.09μg/mL.PLGA@TPE@Ag质量浓度为20μg/mL时对金黄色葡萄球菌和大肠杆菌的抑制率都高达90％以上.载药体系PLGA@TPE@Ag对细菌细胞内部形态的破坏可能是导致其细菌被抑制存活的主要机制.小鼠器官毒性试验明确PLGA@TPE@Ag无毒性.复合载药体系的抑菌活性相对于单一的载药体系有极大的提高.     

In-depth investigation on the factors affecting the performance of high oil-absorption resin by response surface method

A series of high oil-absorption resins with low cross-linking degree were synthesized by suspension polymerization using stearyl methacrylate(SMA), 2-Ethylhexyl methacrylate(EHMA), and styrene(St) as monomers.Response surface methodology(RSM) with central composite design(CCD) was also applied to determine the optimal parameters that are mainly known to affect their synthesis. Thus, the effects of the monomer mass ratio(EHMA:SMA), the rigid monomer(St) dosage, the porous agent(acetone) dosage, and their pairwise interaction on the resin's oil-absorption capacity were analyzed, highlighting PSES-R_2 as the resin with the optimum performance. The pure oil-absorption rates of PSES-R2 for gasoline, diesel, and kerosene were 11.19 g·g~(-1),16.25 g·g~(-1), and 14.84 g·g~(-1), respectively, while the oil removal rates from oily wastewater were 98.82%,65.11%, and 99.63%, respectively.     

绿色有效合成N,N,N-三甲基-1-金刚烷基季铵碱

报道了一种安全、绿色、高效合成N,N,N-三甲基-1-金刚烷基季铵碱的方法.首先,以1-金刚烷胺为原料,碳酸二甲酯(DMC)为甲基化试剂,合成中间体N,N,N-三甲基-1-金刚烷基季铵盐.然后,中间体与氢氧化钙反应,得到最终产物N,N,N-三甲基-1-金刚烷基季铵碱.通过1HNMR和13CNMR对季铵盐和季铵碱的结构进行了表征.分别考察了催化剂、反应物物质的量比〔n(1-金刚烷胺):n(DMC)〕、反应温度和时间对N,N,N-三甲基-1-金刚烷基季铵盐收率的影响.得到的最佳反应条件为:N,N-二甲基甲酰胺(DMF)作为催化剂,且m(DMF)/m(1-金刚烷胺)=0.25,n(1-金刚烷胺):n(DMC)=1:8,反应温度和时间分别为140℃和5 h.在该条件下,N,N,N-三甲基-1-金刚烷基季铵盐的收率可达97.3％.     

Formation of Proto-Kranz in C3 Rice Induced by Spike-Stalk Injection Method

Introduction of C4 photosynthetic traits into C3 crops is an important strategy for improving photosynthetic capacity and productivity. Here, we report the research results of a variant line of sorghum–rice (SR) plant with big panicle and high spikelet density by introducing sorghum genome DNA into rice by spike-stalk injection. The whole-genome resequencing showed that a few sorghum genes could be integrated into the rice genome. Gene expression was confirmed for two C4 photosynthetic enzymes containing pyruvate, orthophosphate dikinase and phosphoenolpyruvate carboxykinase. Exogenous sorghum DNA integration induced a series of key traits associated with the C4 pathway called “proto-Kranz” anatomy, including leaf thickness, bundle sheath number and size, and chloroplast size in bundle sheath cells. Significantly, transgenic plants exhibited enhanced photosynthetic capacity resulting from both photosynthetic CO₂-concentrating effect and improved energy balance, which led to an increase in carbohydrate levels and productivity. Furthermore, such rice plant exhibited delayed leaf senescence. In summary, this study provides a proof for the feasibility of inducing the transition from C3 leaf anatomy to proto-Kranz by spike-stalk injection to achieve efficient photosynthesis and increase productivity.     

3D Printing Conductive Composites with Poly(ionic liquid) as a Noncovalent Intermedia to Fabricate Carbon Circuits

In this study, a kind of imidazole type poly(ionic liquid) ([PEP-MIM]Cl) is synthesized, which can disperse carbon effectively. [PEP-MIM]Cl is used as an intermediate to coat carbon on the poly(acrylic acid)(PAA-co-MBA) via ion exchange to obtain conductive polymer composite (CPC). A series of characterizations are performed. Experiments show that carbon can be coated on the PAA-co-MBA uniformly, and compared with using carbon as filler, this method requires less carbon to achieve good conductive performance. The carbon layer on the polymer's surface is enriched via the swelling-shrinking properties of PAA-co-MBA according to the SEM images. Furthermore, in combination with 3D printing technology, PAA-co-MBA can be designed into different shapes to achieve various functions such as pressure-sensing element. Finally, a new type of CPC named carbon clad polymeric laminate (CCPL) is prepared by using the carbon coating method and 3D printing technology. It has the potential to replace copper clad laminate (CCL) and printed circuit board (PCB), to a certain extent. This technology expands the preparation method and application of the CPC such as flexible and wearable conductive fabrics.     

岩溶区石灰石矿山溶洞探测分析

江西南城南方水泥有限公司蒋源矿区矿山开采过程中发现了溶洞,并利用空洞仪（一种物探设备）对溶洞探测并采集数据以及使用RTK对溶洞分布情况进行坐标数据采集。经过对空洞仪成像分析,结合现场采集的数据制作出溶洞空间分布图,精确掌握溶洞发育的规模、空间状态,对制定岩溶发育区域矿山开采、爆破施工方案、应急预案,以及确保施工安全起到了非常重要的作用。     

Effects of Ultrasonic Vibration on Material Flow and Thermal Cycles in Friction Stir Welding of Dissimilar Al/Mg Alloys

Comparative experiments are performed in friction stir welding (FSW) of dissimilar Al/Mg alloys with and without assistance of ultrasonic vibration. Metallographic characterization of the welds at transverse cross sections reveals that ultrasonic vibration induces differences in plastic material flow in two conditions. In FSW, the plastic material in the peripheral area of shoulder-affected zone (SAZ) tends to flow downward because of the weakening of the driving force of the shoulder, and a plastic material insulation layer is formed at the SAZ edge. When ultrasonic vibration is exerted, the stirred zone is divided into the inner and outer shear layers, the downward material flow trend of the inner shear layer disappears and tends to flow upward, and the onion-ring structure caused by the swirl motion is avoided in the pin-affected zone. By improving the flow behavior of plastic materials in the stirred zone, ultrasonic vibration reduces the heat generation, accelerates the heat dissipation in nugget zone and changes the thermal cycles, thus inhibiting the formation of intermetallic compound layers.

     

液压机本体柔性化设计相关技术的研究

针对液压机本体设计特点，在液压机本体CAD应用系统的开发中，引入了柔性化设计的概念，以Pro／E为建模后台、VB6．0为操作语言，研究了柔性化设计的相关技术，并提出了相关解决方案，并为以：Pro／E为后台的应用系统的开发提供了一种可行方案。     

鞍钢鲅鱼圈4038m3高炉高比例使用中块焦炭生产实践

针对鞍钢股份有限公司鲅鱼圈钢铁分公司4038 m3高炉高比例使用中块焦炭后出现的风量萎缩、顺行变差,尤其是高炉休送风恢复过程中炉缸活跃性差、煤气流中心通道打不开、频繁崩滑料现象,提出采取合理匹配上下部调剂、组织好炉前渣铁排放、小焦布料制度以及改善休风料结构等措施.实践后,高炉实现了中块焦比为90 kg/t情况下的长期稳定顺行,休送风恢复未出现超时现象,适应了高比例使用中块焦炭的生产.     

2205双相不锈钢模拟焊接HAZ组织与性能

采用热模拟法研究了2205DSS焊接HAZ的组织与性能，探讨了冷却时间对模拟HAZ冲击韧性的影响规律。结果表明：冷却时间对组织及性能有很大的影响，随冷却时间的延长，铁素体含量减少，奥氏体含量增加，冲击韧性增大：随冷却时间延长，模拟组织显微硬度降低，而且模拟组织中铁素体的硬度低于奥氏体的硬度：固定冷却时间t8／5时，随冷却时间t12／8的增加，冲击韧性提高：固定冷却时间t12／8时，随冷却时间t8／5的增加，冲击韧性降低。