Vibration analysis of submerged thin FGM cylindrical shells

This study gives a brief work on vibration characteristics of cylindrical shells submerged in an incompressible fluid. The shell is presumed to be structured from functionally graded material. The effect of the fluid is introduced by using the acoustic wave equation. Love’s first order thin shell theory is utilized in the shell dynamical equations. The problem is framed by combining shell dynamical equations with the acoustic wave equation. Fluid-loaded terms are associated with Hankel function of second kind. Wave propagation approach is employed to solve the shell problem. Some comparisons of numerical results are performed for the natural frequencies of simply supported-simply supported, clamped-clamped and clamped-simply supported boundary conditions of isotropic as well as functionally graded cylindrical shells to check the validity of the present approach. The influence of fluid on the submerged functionally graded cylindrical shells is noticed to be very pronounced.     

Porous Gold Nanoshells on Functional NH2‐MOFs: Facile Synthesis and Designable Platforms for Cancer Multiple Therapy

AuroShell nanoparticles (sealed gold nanoshell on silica) are the only inorganic materials that are approved for clinical trial for photothermal ablation of solid tumors. Based on that, porous gold nanoshell structures are thus critical for cancer multiple theranostics in the future owing to their inherent cargo‐loading ability. Nevertheless, adjusting the diverse experimental parameters of the reported procedures to obtain porous gold nanoshell structures is challenging. Herein, a series of amino‐functionalized porous metal–organic frameworks (NH₂‐MOFs) nanoparticles are uncovered as superior templates for porous gold nanoshell deposition (NH₂‐MOFs@Au_shell) by means of a more facile and general one‐step method, which combines the enriched functionalities of NH₂‐MOFs with those of porous gold nanoshells. Moreover, in order to illustrate the promising applications of this method in biomedicine, platinum nanozymes‐encapsulated NH₂‐MOFs are further designed with porous gold nanoshell coating and photosensitizer chlorin e6 (Ce6)‐loaded nanoparticles with continuous O₂‐evolving ability (Pt@UiO‐66‐NH₂@Au_shell‐Ce6). The combination of photodynamic and photothermal therapy is then carried out both in vitro and in vivo, achieving excellent synergistic therapeutic outcomes. Therefore, this work not only presents a facile strategy to fabricate functionalized porous gold nanoshell structures, but also illustrates an excellent synergistic tumor therapy strategy.     

EDM of Ti-6Al-4V: Electrode and polarity selection for minimum tool wear rate and overcut

Titanium and its alloys especially Ti-6Al-4V are being widely used numerous application areas. In addition to have iconic properties, Ti-6Al-4V is considered as challenging material in machining perspective that is why it has captured global research focus. In this research, electric discharge machining of Ti-6Al-4V has been carried out by employing four different types of electrode materials (graphite, aluminum, copper, and brass) assigned with two alternate polarities (positive and negative). Selection of the most appropriate tool material and electrode polarity is the important aspect needed to be explored for this alloy. In addition to polarity, discharge current, and pulse time ratio have been considered as process variables owing to have their direct influence in electric discharge machining. Taguchi L9 array has been employed for each of the four electrodes with positive polarity and similarly L9 with negative polarity. Thus, a total number of 72 experiments have been conducted. Tool wear rate and overcut (OC) around the machined surfaces are the response characteristics to be investigated in order to achieve minimum amounts of both of these two responses. Selection of the most suitable tool with common tool polarity has been carried out meeting the decision criteria of minimum tool wear and minimum OC.