Solitary intraosseous infantile myofibroma of the orbital roof

BACKGROUND: There are several rare tumors that can cause proptosis in an infant, including infantile myofibroma. METHODS: A 3-month-old infant developed a painless, bone-destructive superomedial orbital mass, raising concern for orbital malignant neoplasms. Computed tomography disclosed a bone-destructive mass of the sphenoid wing. On magnetic resonance imaging, the intraosseous mass was well-circumscribed, surrounded by cortical bone, and showed prominent enhancement. RESULTS: Superomedial orbitotomy and biopsy revealed a lesion composed of spindled to stellate cells, without mitotic activity, set in a fibromyxoid stroma. Immunohistochemical stains were positive for vimentin and actin. Ultrastructurally, there were actinlike thin filaments, mitochondria, and rough endoplasmic reticulum confirming a myofibroblastic proliferation and supporting the diagnosis of congenital infantile myofibroma. CONCLUSION: Infantile myofibroma is a benign tumor that occurs rarely in the ocular region but can cause prominent bone destruction, misleading the clinician to suspect a malignant neoplasm.     

Phase I control chart based on a kernel estimator of the quantile function

To measure the statistical performance of a control chart in Phase I applications, the in‐control average run length (ARL) is the most frequently used parameter. In typical start up situations, control limits must be computed without knowledge of the underlying distribution of the quality characteristic. Assumptions of an underlying normal distribution can increase the probability of false alarms when the underlying distribution is non‐normal, which can lead to unnecessary process adjustments. In this paper, a control chart based on a kernel estimator of the quantile function is proposed. Monte Carlo simulation was used to evaluate the in‐control ARL performance of this chart relative to that of the Shewhart individuals control chart. The results indicate that the proposed chart is more robust to deviations in the assumed underlying distribution (with respect to the in‐control ARL) and results in an alternative method of designing control charts for individual units. Copyright © 2011 John Wiley & Sons, Ltd.     

The galanin antagonist, M-15, inhibits growth hormone release in rats

The neuropeptide, galanin, has been implicated in the regulation of rat growth hormone (rGH) release. In the present study, adult male rats were implanted dually with cannulae to the lateral cerebral ventricle and the right atrium. After surgical recovery, rats were infused with M-15, a specific galanin antagonist, into the lateral ventricle. During the course of this brain infusion, rats were subjected to serial blood sampling with red cell and artificial plasma replacement under stress-free conditions. Plasma was saved for rGH assay. Treatment with M-15 reduced rGH pulse amplitude and pulse frequency when compared to vehicle-infused controls. These data suggest that brain galanin participates in the ongoing stimulation of pulsatile rGH release in the adult male rat.     

Testing of commercial optical media

Data integrity is a primary concern for the users of any data storage medium. For optical data storage, the integrity is directly related to the performance and defect level of the storage media and to how they change as the media age. While media materials and thin-film stack designs are chosen with the goal of achieving high data integrity and reliability, variations in the media manufacturing processes themselves often can determine how the media will behave. These variations can be found through detailed and careful characterization testing. The authors describe some of the test methods used for characterizing rewritable media and discuss some results obtained while surveying commercially available media     

The effects of impoundment and non‐native species on a river food web in Mexico's central plateau

Habitat modifications, non‐native species and other anthropogenic impacts have restructured fish communities in lotic ecosystems of central Mexico. Conservation of native fishes requires understanding of food web changes resulting from the introduction of non‐native species, flow alteration and other human impacts. Using δ¹³C and δ¹⁵N analysis of fishes and invertebrates we investigated the effects of non‐native species, and reservoirs on food webs of the Laja river ecosystem (Guanajuato, central Mexico). We estimated trophic position (TP), relative trophic niche and food web dispersion at 11 reservoir, river and tailwater sites. Reservoirs and non‐native fishes modified food webs in the Laja. Food web dispersion was greater in reservoir than in tailwater and river sites. Reservoir food webs had the greatest range of δ¹³C values, indicating a more diverse resource base compared to rivers. δ¹³C values increased with distance downstream from reservoirs, suggesting declining subsidies of river food webs by reservoir productivity. Stable isotopes revealed potential effects of non‐native fishes on native fishes via predation or competition. Non‐native Micropterus salmoides were top predators in the system. Non‐natives Cyprinus carpio, Oreochromis mossambicus and Carassius auratus exhibited lowest TP in the Laja but overlapped significantly with most native species, indicating potential for resource competition. Native Chirostoma jordani was the only species with a significantly different trophic niche from all other fish. Many rivers in central Mexico share similar anthropogenic impacts and similar biotas, such that food web patterns described here are likely indicative of other river systems in central Mexico. Copyright © 2008 John Wiley & Sons, Ltd.     

Operating reserve determination and its influence on the operating costs of interconnected power systems

A methodology to carry out reliability studies to compute operating reserve requirements of interconnected systems is formulated.This paper shows the application of developments carried out at ‘Instituto de Energía Eléctrica’ in order to calculate the operating reserve requirements, their composition in relation to the access times of different kinds of reserve, and the influence that equipment variations will have on the electric power system operation costs.The calculation of power interchange between areas is performed with a stochastic model of the system. In this model the different levels of assistance capacity of each area are associated with their occurrence probabilities. Covering of own demand has priority. Interconnecting lines between areas are modeled by probabilities associated with their possible states.This methodology allows adequate consideration of operating conditions in power systems planning. System optimal operation costs are calculated under the constraint that there is sufficient operating reserve (stand-by plus spinning reserve) to guarantee a given reliability level.The main aim of this work was the application of this methodology to the Sistema Nacional Interconectado Argentino (Argentine National Interconnected System) for assessing a first approach to operating reserve composition and requirements. In addition, the influence on the operating costs of including a pumped storage power plant located in the province of Buenos Aires is evaluated.     

A new approach for power system online DSA using distributed processing and fuzzy logic

In this paper, a new approach for power system online dynamic security assessment, as well as a tool for calculating the proposed fuzzy dynamic security index is presented. This proposal is based on a three-stage fuzzy inference system, which composes the fuzzy dynamic security index making use of seven performance indexes herein defined. The calculation of the performance indexes is based on the results obtained through dynamic simulations of the system behaviour after each one of the credible contingencies in a given operation state. With the aim of reducing the calculation time a novel distributed processing of the dynamic simulations is also developed. High voltage systems are used to illustrate the ideas presented in the paper.     

Vaccination of pregnant cows with EspA, EspB, γ-intimin, and Shiga toxin 2 proteins from Escherichia coli O157:H7 induces high levels of specific colostral antibodies that are transferred to newborn calves

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major cause of intestinal disease and hemolytic uremic syndrome, a serious systemic complication that particularly affects children. Cattle are primary reservoirs for EHEC O157:H7 and the main source of infection for humans. Vaccination of cattle with different combinations of bacterial virulence factors has shown efficacy in decreasing EHEC O157:H7 shedding. It is, therefore, important to demonstrate whether vaccination of pregnant cows with EHEC O157:H7 induces high titers of transferable antibodies to avoid early colonization of calves by the bacteria. In this study we evaluated the ability of EspA, EspB, the C-terminal fragment of 280 amino acids of γ-intimin (γ-intimin C₂₈₀) and inactivated Shiga toxin (Stx) 2 proteins to induce specific antibodies in colostrum and their passive transference to colostrum-fed calves. Friesian pregnant cows immunized by the intramuscular route mounted significantly high serum and colostrum IgG responses against EspB and γ-intimin C₂₈₀ that were efficiently transferred to their calves. Antibodies to EspB and γ-intimin C₂₈₀ were detected in milk samples of vaccinated cows at d 40 postparturition. Significant Stx2-neutralizing titers were also observed in colostrum from Stx2-vaccinated cows and sera from colostrum-fed calves. The results presented showed that bovine colostrum with increased levels of antibodies against EHEC O157:H7 may be obtained by systemic immunization of pregnant cows, and that these specific antibodies are efficiently transferred to newborn calves by feeding colostrum. Hyperimmune colostrum and milk may be an alternative to protect calves from early colonization by EHEC O157:H7 and a possible key source of antibodies to block colonization and toxic activity of this bacterium