Immobilization of dendrimers on Si-C linked carboxylic acid-terminated monolayers on silicon(111)

Poly(amidoamine) dendrimers were attached to activated undecanoic acid monolayers, covalently linked to smooth silicon surfaces via Si-C bonds. The resulting ultra-thin dendrimer films were characterized by X-ray photoelectron spectroscopy (XPS), X-ray reflectometry (XR) and atomic force microscopy (AFM). XPS results suggested amide bond formation between the dendrimer and the surface carboxylic acid groups. XR yielded thicknesses of 10 Å for the alkyl region of the undecanoic acid monolayer and 12 Å for the dendrimer layer, considerably smaller than the diameter of these spherical macromolecules in solution. This was consistent with AFM images showing collapsed dendrimers on the surface. It was concluded that the deformation arose from a large number of amine groups on the surface of each dendrimer reacting efficiently with the activated surface, whereby the dendrimers can deform to fill voids while spreading over the activated surface to form a homogeneous macromolecular layer.     

Engineering better wheelchairs to enhance community participation.

With about 2.2 million Americans currently using wheeled mobility devices, wheelchairs are frequently provided to people with impaired mobility to provide accessibility to the community. Individuals with spinal cord injuries, arthritis, balance disorders, and other conditions or diseases are typical users of wheelchairs. However, secondary injuries and wheelchair-related accidents are risks introduced by wheelchairs. Research is underway to advance wheelchair design to prevent or accommodate secondary injuries related to propulsion and transfer biomechanics, while improving safe, functional performance and accessibility to the community. This paper summarizes research and development underway aimed at enhancing safety and optimizing wheelchair design.     

Working memory capacity and the top-down control of visual search: Exploring the boundaries of "executive attention".

The executive attention theory of working memory capacity (WMC) proposes that measures of WMC broadly predict higher order cognitive abilities because they tap important and general attention capabilities (R. W. Engle & M. J. Kane, 2004). Previous research demonstrated WMC-related differences in attention tasks that required restraint of habitual responses or constraint of conscious focus. To further specify the executive attention construct, the present experiments sought boundary conditions of the WMC-attention relation. Three experiments correlated individual differences in WMC, as measured by complex span tasks, and executive control of visual search. In feature-absence search, conjunction search, and spatial configuration search, WMC was unrelated to search slopes, although they were large and reliably measured. Even in a search task designed to require the volitional movement of attention (J. M. Wolfe, G. A. Alvarez, & T. S. Horowitz, 2000), WMC was irrelevant to performance. Thus, WMC is not associated with all demanding or controlled attention processes, which poses problems for some general theories of WMC. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Maternally modulated infant separation responses are regulated by D2-family dopamine receptors.

Although dopamine is necessary for mammalian adult pair-bond formation and maternal behavior, its function in infant social behavior and attachment has been less thoroughly explored. The vocalization rate of an isolated rat pup is influenced by recent social contact. Interactions with the dam potentiate vocalization rate. Interactions with littermates or adult males do not. Systemic administration of the D2-family agonist quinpirole specifically blocked maternal potentiation at doses that did not alter vocalization rate in an isolation prior to dam contact. This result was not explained by quinpirole's effects on body temperature or locomotion. The results are consistent with a role for dopamine in infant social behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Review of The Robot's Rebellion: Finding Meaning in the Age of Darwin.

Review of book The Robot's Rebellion: Finding Meaning in the Age of Darwin by Keith E. Stanovich (see record 2004-95228-000). In his interesting scholarly book, The Robot's Rebellion, Stanovich leads us on a journey to find meaning in a world populated by mortal biological vehicles, the robots, put on earth to replicate their masters' selfish genes. If the genes do a satisfactory job programming the robots, then the genes replicate in perpetuity and are, therefore, immortal. Stanovich's basic assumptions are: a) vehicles are designed to replicate genes; b) at least in human animals, the brain houses two minds; c) the first mind, System 1 or The Autonomous Set of Systems, evolved much earlier in evolutionary history than did the second mind, System 2 or the Analytic System; d) System 1 is associative, parallel, fast to respond, and designed to automatically serve its genetic master; e) System 2 is rule-based, serial, slow to respond, not aware of System 1 functioning but sometimes privy to System 1 output, controls executive functioning, and is capable of self-evaluation and leading the rebellion against its genetic master; and, f) memes, culturally generated ideas passed on by nongenetic means, can sometimes be as effective as System 1 at squashing the rebellion. These assumptions are derived from work in cognitive science and evolutionary biology, and provide a solid foundation for the book. Both the metaphor and the basic assumptions are embedded in detailed and informative reviews of decision theory, evolutionary psychology, memetic theory, rational philosophy, and utility theory. The interweaving of metaphor and review provides a framework that allows Stanovich to make inferences to help the general reader understand "the implications of modern science" (p. xi). He also develops criteria to evaluate memes that are needed in his quest to find meaning in human existence. In combination with the basic assumptions, these criteria are used to create an ethical ideology that will be embraced by some readers. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Experimental Investigation of Nonconventional Confinement for Concrete Using FRP

The present study investigates experimentally the behavior of concrete confined with fiber reinforced polymers (FRP) in the form of jackets which are applied according to a number of nonconventional techniques. First, the effectiveness of various jacketing configurations combined with anchors as a measure of increasing the strength and deformability of L-shaped columns is investigated. It is concluded that easy to install and low-cost anchors made of resin impregnated fibers properly placed at the reentrant corner of L-shaped columns enable excellent mobilization of confining stresses supplied by the FRP jackets. Next, a number of alternative confinement methods are investigated on concrete cylinders, aimed at quantifying the effectiveness of (1) unbonded jacketing, (2) spirally applied strips attached only at their ends, and (3) jacketing directly on concrete with mortar plastering. Although the study may be regarded as preliminary, it provides useful experimental support to a number of techniques which have the potential to open new horizons in the field of externally applied FRP for enhancing concrete confinement.     

Role of Inventory Buffers in Construction Labor Performance

Buffers of material stockpile (inventory) are formed at the work level in construction to help manage production. The size of material stockpiles often has an important bearing on construction project performance. In construction projects, where conditions are often uncertain and variable, some have suggested that buffers be sized and located according to the conditions. New management thinking like lean construction and theory of constraints suggests that the size of buffers needs to be managed carefully, because when oversized, buffers are wasteful, impede workflow, and hinder performance. Research has shown that project variability can be affected with the careful deployment of buffers but has not really evaluated the impact on construction labor performance. This paper reports an exploratory analysis of the relationship between inventory (buffers) and construction labor performance with data collected from three commercial projects in Brazil. In this study, the size of the buffer between rebar fabrication and installation in the construction of a structural system is compared to the labor performance of the fabrication and installation crews. The results show that some buffer helps achieve the best labor performance in the construction operations studied.     

Rotary Blanking ‐ a New Manufacturing Process

Rotary blanking is a method of blanking and punching with rotating tools whereby the cutting tools are fixed to a pair of rollers performing a continuous blanking operation on a strip of sheet metal. The purpose of this paper is to outline the determining conditions under which the rotary blanking process takes place and to discuss advantages, restrictions, applications and optimization of this technology.     

Predicting change for individual psychotherapy clients on the basis of their nearest neighbors.

This study extended client-focused research by using the nearest neighbor (NN) approach, a client-specific sampling and prediction strategy derived from research on alpine avalanches. Psychotherapy clients (N = 203) seen in routine practice settings in the United Kingdom completed a battery of intake measures and then completed symptom intensity ratings before each session. Forecasts of each client's rate of change and session-by-session variability were computed on the basis of that client's NNs (n = 10-50 in different comparisons). Alternative forecasts used linear or log-linear slopes and were compared with an alternative prediction strategy. Results showed that the NN approach was superior to the alternative model in predicting rate of change, though the advantage was less clear for predicting variability. (PsycINFO Database Record (c) 2010 APA, all rights reserved)