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排序方式: 共有299条查询结果,搜索用时 31 毫秒
101.
Thomas Dippong Oana Cadar Firuta Goga Dana Toloman Erika Andrea Levei 《International journal of molecular sciences》2022,23(22)
The structure, morphology, and sonophotocatalytic activity of Ni-Zn-Co ferrite nanoparticles, embedded in a SiO2 matrix and produced by a modified sol-gel method, followed by thermal treatment, were investigated. The thermal analysis confirmed the formation of metal succinate precursors up to 200 °C, their decomposition to metal oxides and the formation of Ni-Zn-Co ferrites up to 500 °C. The crystalline phases, crystallite size and lattice parameter were determined based on X-ray diffraction patterns. Transmission electron microscopy revealed the shape, size, and distribution pattern of the ferrite nanoparticles. The particle sizes ranged between 34 and 40 nm. All the samples showed optical responses in the visible range. The best sonophotocatalytic activity against the rhodamine B solution under visible irradiation was obtained for Ni0.3Zn0.3Co0.4Fe2O4@SiO2. 相似文献
102.
Paul R. Fisher Claire Y. Allan Oana Sanislav Anna Atkinson Kevin R. W. Ngoei Bruce E. Kemp Elsdon Storey Danuta Z. Loesch Sarah J. Annesley 《International journal of molecular sciences》2021,22(19)
The X-linked FMR1 gene contains a non-coding trinucleotide repeat in its 5’ region that, in normal, healthy individuals contains 20–44 copies. Large expansions of this region (>200 copies) cause fragile X syndrome (FXS), but expansions of 55–199 copies (referred to as premutation alleles) predispose carriers to a neurodegenerative disease called fragile X-associated tremor/ataxia syndrome (FXTAS). The cytopathological mechanisms underlying FXTAS are poorly understood, but abnormalities in mitochondrial function are believed to play a role. We previously reported that lymphoblastoid cell lines (LCLs, or lymphoblasts) of premutation carriers have elevated mitochondrial respiratory activities. In the carriers, especially those not clinically affected with FXTAS, AMP-activated protein kinase (AMPK) activity was shown to be elevated. In the FXTAS patients, however, it was negatively correlated with brain white matter lesions, suggesting a protective role in the molecular mechanisms. Here, we report an enlarged and extended study of mitochondrial function and associated cellular stress-signaling pathways in lymphoblasts isolated from male and female premutation carriers, regardless of their clinical status, and healthy controls. The results confirmed the elevation of AMPK and mitochondrial respiratory activities and reduction in reactive O2 species (ROS) levels in premutation cells and revealed for the first time that target of rapamycin complex I (TORC1) activities are reduced. Extensive correlation, multiple regression, and principal components analysis revealed the best fitting statistical explanations of these changes in terms of the other variables measured. These suggested which variables might be the most “proximal” regulators of the others in the extensive network of known causal interactions amongst the measured parameters of mitochondrial function and cellular stress signaling. In the resulting model, the premutation alleles activate AMPK and inhibit both TORC1 and ROS production, the reduced TORC1 activity contributes to activation of AMPK and of nonmitochondrial metabolism, and the higher AMPK activity results in elevated catabolic metabolism, mitochondrial respiration, and ATP steady state levels. In addition, the results suggest a separate CGG repeat number-dependent elevation of TORC1 activity that is insufficient to overcome the inhibition of TORC1 in premutation cells but may presage the previously reported activation of TORC1 in FXS cells. 相似文献
103.
Parallel knowledge processing on SNAP 总被引:1,自引:0,他引:1
The semantic network array processor (SNAP) is a specialized, highly parallel architecture for knowledge representation and reasoning. The instruction set has been carefully designed to reflect the requirements of semantic network processing. SNAP is a marker propagation architecture, where the passing of markers between cells plays a fundamental role. The movement of markers between cells is controlled by a set of propagation rules. Various reasoning mechanisms were implemented using these propagation rules. A simulator was developed, and knowledge processing examples, such as inheritance, recognition, and classification, were tested. By comparing the simulation results with the same examples run on the Connection Machine, it was found that SNAP outperforms the Connection Machine over a broad range of knowledge processing examples by a factor of 1000 or more 相似文献
104.
H Oana RW Hammond JJ Schwinefus SC Wang M Doi MD Morris 《Canadian Metallurgical Quarterly》1998,70(3):574-579
Capillary electrophoresis in dilute and semidilute (slightly entangled) hydroxyethyl cellulose (HEC) is shown to separate linear double-stranded DNA (ds-DNA) and supercoiled plasmid DNA in the size range 1-16 thousand base pairs in 3 min. The mobilities of linear ds-DNA fragments are stronger functions of electric field strength and buffer concentration than the mobilities of supercoiled plasmids. The effects of HEC concentration and molecular weight are similar for both forms of DNA. The behavioral differences, which are attributed to the greater stiffness of the plasmids, can be used to define conditions that maximize resolution of supercoiled and linear ds-DNA of the same or similar number of base pairs. 相似文献
105.
106.
A methodology for transforming the original search space into an equivalent but minimal search space is proposed. First, the concept of dependences leads to a procedure for reduction of the search space. The search procedure using this method can produce a minimal and complete search space. It is shown that this method is applicable to parallel search as well. An added advantage of this method is that it does not exclude the use of heuristics. π-λ transformation is introduced to reduce the parallel search space 相似文献
107.
J Galon I Moldovan A Galinha MA Provost-Marloie H Kaudewitz S Roman-Roman WH Fridman C Sautès 《Canadian Metallurgical Quarterly》1998,28(7):2101-2107
CD16 (FcgammaR type III) is a low-affinity IgG Fc receptor (R) that exists in two isoforms, a transmembrane FcgammaRIIIa expressed by NK cells and monocytes, and a phosphatidylinositol-linked FcgammaRIIIb expressed by neutrophils. A soluble form of CD16 (sCD16) circulates in plasma. The cleavage site and the nature of the enzyme(s) involved in production of sCD16 were investigated. Soluble CD16 was purified to apparent homogeneity from human serum by eight steps, including anion exchange and immunoaffinity chromatography. Serum sCD16 was sequenced at both ends, as well as a recombinant form of sCD16 used as control. N-terminal sequencing demonstrated that serum sCD16 originates from neutrophil FcgammaRIIIb and C-terminal sequencing suggested that the cleavage site is between Val 196 and Ser 197, close to the membrane anchor. Addition of a hydroxamate-based inhibitor of Zn2+ metalloproteinases (RU36156) led to a dramatic decrease of sCD16 production by phorbol 12-myristate 13-acetate-activated neutrophils, whereas inhibitors of serine proteinases had no significant effect, showing the metalloproteinase dependence of this cleavage process. 相似文献
108.
I. Vasiliu M. Gartner L. Todan M. Elisa F. Ungureanu A. Moldovan M. Zaharescu 《Thin solid films》2007,515(16):6601-6605
A comparative study of the sol-gel films prepared in the SiO2-P2O5 system starting with triethylphosphate, triethylphosphite and phosphoric acid as P precursors was performed. The work addresses basic aspects of physics, chemistry, and engineering of oxide films for applications in microelectronics, sensing, nano-photonics, and optoelectronics by establishing the influence of different precursors on the composition, structure and optical properties of the obtained films. The influence of the type of substrate (glass and indium tin oxide coated glass) and of the thermal treatment (200 and 500 °C) on their structure and properties was studied. By spectroscopic ellipsometry, X-Ray photoemission spectroscopy and atomic force microscopy measurements the high vaporization of the phosphorous during the densification of the films by thermal treatment was noticed when P-alkoxides were used. The phosphoric acid that forms chemical bond with silica network during the sol-gel process leads to better incorporation of P in the silica network as compared to the P-alkoxides. 相似文献
109.
A series of novel hybrid materials have been prepared by the Diels-Alder reaction of poly(vinyl furfural) to maleimide compound followed by the sol-gel condensation of triethoxysilyl groups with water and acetic acid. The poly(vinyl furfural) having acetalization degree of 15% and 25% were obtained by the acid-catalyzed homogenous acetalization of poly(vinyl alcohol) with 2-furfural in a nonaqueous media. The resulting hybrid materials were characterized by the Fourier transform infrared spectroscopy, X-ray diffractions, scanning electron microscopy and atomic force microscopy. The thermal properties were investigated by differential scanning calorimetry, thermogravimetric and dynamic mechanical analysis. The thermal stability of the hybrid materials increased with increasing the inorganic content. 相似文献
110.
Pascu O Caicedo JM López-García M Canalejas V Blanco Á López C Arbiol J Fontcuberta J Roig A Herranz G 《Nanoscale》2011,3(11):4811-4816
We report on an extremely fast and versatile synthetic approach, based on microwave assisted sol-gel chemistry, that allows a conformal nanometric coating of intricate three-dimensional structures. Using this methodology, we have achieved a conformal coverage of large areas of three-dimensional opals with a superparamagnetic manganese ferrite layer, yielding magneto-photonic crystals with excellent quality. The use of a ternary oxide for the ultrathin coating demonstrates the potential of this methodology to realize three-dimensional structures with complex materials that may find applications beyond photonics, such as energy, sensing or catalysis. 相似文献