Protein interaction networks: centrality,modularity, dynamics,and applications

In the post-genomic era, proteomics has achieved significant theoretical and practical advances with the development of high-throughput technologies. Especially the rapid accumulation of protein-protein interactions (PPIs) provides a foundation for constructing protein interaction networks (PINs), which can furnish a new perspective for understanding cellular organizations, processes, and functions at network level. In this paper, we present a comprehensive survey on three main characteristics of PINs: centrality, modularity, and dynamics. 1) Different centrality measures, which are used to calculate the importance of proteins, are summarized based on the structural characteristics of PINs or on the basis of its integrated biological information; 2) Different modularity definitions and various clustering algorithms for predicting protein complexes or identifying functional modules are introduced; 3) The dynamics of proteins, PPIs and sub-networks are discussed, respectively. Finally, the main applications of PINs in the complex diseases are reviewed, and the challenges and future research directions are also discussed.     

顶部定常吸气对高层建筑模型气动力的影响

为减少高层建筑受到的风荷载,提高高层建筑抗风性能,提出一种顶部吸气的主动控制方法。在一高宽比为H/d=5的正方形截面柱体的高层建筑模型上,通过在其顶部前边缘开设狭缝进行吸气来实现流动控制。通过风洞试验研究了顶部吸气对气动力与顶部分离流的影响.利用流动可视化与流场测试结果揭示了顶部狭缝吸气的控制机理.实验对比了不同吸气系数Q(=U/U_∞,U为狭缝吸气速度)对气动力控制效果的影响,并对Q=0,1和3的三种工况下风压分布与顶部剪切流进行了详细对比.研究发现狭缝吸气改变了顶部分离流特性,并对模型所有高度上的气动力均有显著影响.Q=1时控制效果最佳,脉动阻力与脉动升力分别减小17.8%和45.5%.此时顶面分离流被削弱并伴随有再附现象且湍流强度较大,最有利于顶部剪切流与尾流间的动量交换,从而削弱柱体展向涡脱落与脉动气动力.     

Aerodynamic performance analysis of trains on slope topography under crosswinds

This work used the computational fluid dynamics method combined with full-scale train tests to analyze the train aerodynamic performance on special slope topography. Results show that with the increment in the slope gradient, the aerodynamic forces and moment increase sharply. Compared with the flat ground condition, the lateral force, lift force, and overturning moment of the train on the first line increase by 153.2%, 53.4% and 124.7%, respectively, under the slope gradient of 20°. However, with the increment of the windward side's depth, the windbreak effect is improved obviously. When the depth is equal to 10 m, compared with the 0 m, the lateral force, lift force and overturning moment of the train on the first line decrease by 70.9%, 77.0% and 70.6%,respectively. Through analyzing the influence of slope parameters on the aerodynamic performance of the train, the relationships among them are established. All these will provide a basic reference for enhancing train aerodynamic performances under different slope conditions and achieve reasonable train speeds for the operation safety in different wind environments.     

导磁体在汽车零件感应加热中的应用技术

本文简单介绍了导磁体工作的基本原理，并给出在汽车零件大规模生产中所积累的导磁体应用的一些经验，以阐明如何更有效地使用导磁体。     

对变压器真实油温的智能化监测

本文中作者通过FLUENT温度场解析和变压器实物温升试验,找出了变压器油温最热的真实位置,从而提出智能化监测的解决方案,为真实反映油温升提供可靠的依据.     

高温预析出对Al-Zn-Mg-Cu铝合金显微组织、强度和应力腐蚀抗力的影响

通过改变固溶条件 ,对Al Zn Mg Cu高强铝合金采用先高温后低温的两步固溶处理 (高温预析出 )来改善晶内和晶界的析出状态 ,研究了高温预析出对Al Zn Mg Cu铝合金的金相组织、强度和应力腐蚀性能的影响。结果表明 ,4 6 5℃高温预析出在保持较高强度和塑性的同时 ,可以改善合金的抗应力腐蚀性能     

熟料烧结过程中氧化铁反应行为的热力学分析

通过对Fe2O3与碳酸钠、氧化钙以及硅酸钙反应的热力学分析,明确Fe2O3在铝土矿炉料烧结过程中的热力学反应规律。热力学计算、分析结果表明:Fe2O3在正常烧结温度范围内能与Na2CO3或CaO发生反应,但更易与CaO反应形成2CaO.Fe2O3或CaO.Fe2O3,Fe2O3和Na2O.Fe2O3能使2CaO.SiO2和3CaO.2SiO2转变为CaO.SiO2,CaO.SiO2进一步与Na2O.Al2O3或Na2O.Fe2O3反应生成不溶的三元化合物而造成烧结法生产氧化铝过程中Na2O和Al2O3的损失。4CaO.Al2O3.Fe2O3不能由铁酸钙和铝酸钠相互反应产生,而可能是CaO、Al2O3和Fe2O3三者直接反应的产物,且在烧结条件下Na2O.Fe2O3可分解4CaO.Al2O3.Fe2O3。     

双端制动器惯性试验台的设计

随着我国汽车工业的迅猛发展,汽车产量不断增多,车速越来越高,对汽车制动性能要求也越来越高。汽车制动器是汽车上的重要设备,其质量的好坏影响着行车的安全。电惯量模拟是近几年兴起的一种比较先进的负载模拟方法,文章就制动器惯性试验台系统结构以及电惯量模拟的方法进行了比较详细的说明。     

高钒高速钢碳化钒形态的数值化分析

针对碳化钒的不同形态,设计出定量分析软件,并利用形状因子K,实现了高钒高速钢不同碳化物形态数值化处理,当K介于0.785～1.000之间碳化钒形态为团球状;K≤0.223,碳化钒呈开花状.高钒高速钢当碳含量达到4.2%时,K为0.86和当量直径D为0.78μm,碳化物呈团球状均匀分布.     

CA6140车床数控改造中机械装置设计技巧

介绍了普通车床数控改造中机械装置的几个独特设计，使得数控车床纵向进给系统结构更简单、性能更可靠、装拆更方便。