Development of a Position Sensitive Neutron Detector with High Efficiency and Energy Resolution for Use at High-Flux Beam Sources

We are developing a high-efficiency neutron detector with 1 cm position resolution and coarse energy resolution for use at high-flux neutron source facilities currently proposed or under construction. The detector concept integrates a segmented ³He ionization chamber with the position sensitive, charged particle collection methods of a MicroMegas detector. Neutron absorption on the helium produces protons and tritons that ionize the fill gas. The charge is amplified in the field region around a wire mesh and subsequently detected in current mode by wire strips mounted on a substrate. One module consisting of a high-voltage plate, a field-shaping high-voltage plate, a grid and wire strips defines a detection region. For 100 % efficiency, detector modules are consecutively placed along the beam axis. Analysis over several regions with alternating wire strip orientation provides a two-dimensional beam profile. By using ³He, a 1/v absorption gas, each axial region captures neutrons of a different energy range, providing an energy-sensitive detection scheme especially useful at continuous beam sources.     

Life-cycle modeling for adaptive and variant design. Part 1: Methodology

Life-cycle modeling for design (LCMD) is a methodology for assessing the life-cycle impacts for a complex product with many individual components starting from initial design phases when few design specifications have been made. The methodology combines life-cycle assessment (LCA) with probabilistic design methods in a way that forecasts attributes of possible final designs yet reduces information needs. Specifically, LCMD is a methodology for generating arrays of design scenarios that communicate the range of designs being considered by a design team, and estimating missing data for those design scenarios. The main contribution to enhancing standard LCA is the incorporation of methods to estimate physical attributes of individual components for various design options and in four analyses for evaluating the arrays of design scenarios. An automotive case study presented in part 2 of this work demonstrates one application of LCMD.     

Extension of IMC tuning correlations for non-self regulating (integrating) processes

The filter term of a PID with Filter controller reduces the impact of measurement noise on the derivative action of the controller. This impact is quantified by the controller output travel defined as the total movement of the controller output per unit time. Decreasing controller output travel is important to reduce wear in the final control element. Internal Model Control (IMC) tuning correlations are widely published for PI, PID, and PID with Filter controllers for self regulating processes. For non-self regulating (or integrating) processes, IMC tuning correlations are published for PI and PID controllers but not for PID with Filter controllers. The important contribution of this work is that it completes the set of IMC tuning correlations with an extension to the PID with Filter controller for non-self regulating processes. Other published correlations (not based upon the IMC framework) for PID with Filter controllers fix the filter time constant at one-tenth the derivative time regardless of the model of the process. In contrast, the novel IMC correlations presented in this paper calculate a filter time constant based upon the model of the process and the user's choice for the closed-loop time constant. The set point tracking and disturbance rejection performance of the proposed IMC tunings is demonstrated using simulation studies and a bench-scale experimental system. The proposed IMC tunings are shown to perform as well as various PID correlations (with and without a filter term) while requiring considerably less controller action.     

Al2O3 and TiO2 atomic layer deposition on copper for water corrosion resistance

Al(2)O(3) and TiO(2) atomic layer deposition (ALD) were employed to develop an ultrathin barrier film on copper to prevent water corrosion. The strategy was to utilize Al(2)O(3) ALD as a pinhole-free barrier and to protect the Al(2)O(3) ALD using TiO(2) ALD. An initial set of experiments was performed at 177 °C to establish that Al(2)O(3) ALD could nucleate on copper and produce a high-quality Al(2)O(3) film. In situ quartz crystal microbalance (QCM) measurements verified that Al(2)O(3) ALD nucleated and grew efficiently on copper-plated quartz crystals at 177 °C using trimethylaluminum (TMA) and water as the reactants. An electroplating technique also established that the Al(2)O(3) ALD films had a low defect density. A second set of experiments was performed for ALD at 120 °C to study the ability of ALD films to prevent copper corrosion. These experiments revealed that an Al(2)O(3) ALD film alone was insufficient to prevent copper corrosion because of the dissolution of the Al(2)O(3) film in water. Subsequently, TiO(2) ALD was explored on copper at 120 °C using TiCl(4) and water as the reactants. The resulting TiO(2) films also did not prevent the water corrosion of copper. Fortunately, Al(2)O(3) films with a TiO(2) capping layer were much more resilient to dissolution in water and prevented the water corrosion of copper. Optical microscopy images revealed that TiO(2) capping layers as thin as 200 ? on Al(2)O(3) adhesion layers could prevent copper corrosion in water at 90 °C for ~80 days. In contrast, the copper corroded almost immediately in water at 90 °C for Al(2)O(3) and ZnO films by themselves on copper. Ellipsometer measurements revealed that Al(2)O(3) films with a thickness of ~200 ? and ZnO films with a thickness of ~250 ? dissolved in water at 90 °C in ~10 days. In contrast, the ellipsometer measurements confirmed that the TiO(2) capping layers with thicknesses of ~200 ? on the Al(2)O(3) adhesion layers protected the copper for ~80 days in water at 90 °C. The TiO(2) ALD coatings were also hydrophilic and facilitated H(2)O wetting to copper wire mesh substrates.     

Grain fracture in rapid particulate media deformation and a particulate media research roadmap from the PMEE workshops

It is well known that grain fracture plays an important role in quasi-static compaction of particulate media (e.g. civil engineering applications). Grain fracture is frequently the energy-minimizing path which enables particulate media to support large stresses. Less well known is the role that fracture plays in higher-rate particulate media systems. This paper discusses grain-scale & macro-scale evidence for the role of fracture in high-pressure/rate particulate media deformation events. It also presents (Appendix) a related particulate materials research roadmap developed by feedback from the Particulate Materials in Extreme Environments (PMEE) workshops. Experimental evidence is presented from recent sand fracture experiments performed by launching hemispherical-nose projectiles into specially-prepared beds of sand. Particle size analysis, SEM images of virgin & fractured media, and images from the bulk sand fracture & flow are used to illustrate the role of sand fracture. It is shown that as-poured sand exhibits a dilatational response and that mechanically compacted sand exhibits a compaction response when each is stimulated by a high-speed hemi-nose projectile. For compacted sand, particle size analysis suggests that particles near the rear of the target (lower projectile velocities and pressures) are reduced more in size. Fractured sand is shown to exhibit abrasion, attrition and fracture modes with visual self-similarity limited to specific particle size range roughly divided into classes larger or smaller than ~50 microns. Initial particulate media density affects the bulk response to high-pressure/rate events. Varying the density can transition the flow from dilation to compaction-dominated, likely as a function of inter-grain stresses from compaction. Substantial particle fracture is an artifact of both flow cases.     

Engaging High‐Sensation Seekers: The Dynamic Interplay of Sensation Seeking,Message Visual‐Auditory Complexity and Arousing Content

This study extends the research on message‐sensation value (MSV) by treating it as a dynamic stream of complex visual‐auditory information and arousing content (MSV‐d). Real‐time attentional and emotional responses to this dynamic stream during the PSA viewing process are indicated by psychophysiological measures. Dynamic models are used to systematically examine endogenous and exogenous influences on message processing to more accurately understand the effects of MSV‐d variables and individuals' sensation seeking tendencies during the processing of the PSAs. An important finding is that generally, increasing visual‐auditory complexity activates an approach tendency in those with high sensation‐seeking tendencies but activates an avoidance tendency in those with low sensation‐seeking tendencies, and this response pattern is moderated by arousing content.     

Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation

Different cell types possess different miRNA expression profiles, and cell/tissue/organ-specific miRNAs (or profiles) indicate different diseases. Circulating miRNA is either actively secreted by living cells or passively released during cell death. Circulating cell/tissue/organ-specific miRNA may serve as a non-invasive biomarker for allo- or xeno-transplantation to monitor organ survival and immune rejection. In this review, we summarize the proof of concept that circulating organ-specific miRNAs serve as non-invasive biomarkers for a wide spectrum of clinical organ-specific manifestations such as liver-related disease, heart-related disease, kidney-related disease, and lung-related disease. Furthermore, we summarize how circulating organ-specific miRNAs may have advantages over conventional methods for monitoring immune rejection in organ transplantation. Finally, we discuss the implications and challenges of applying miRNA to monitor organ survival and immune rejection in allo- or xeno-transplantation.     

Real-time in situ monitoring of the thermal cure of a bisphenol cyanate: A view toward intelligent processing

A dispersive fiber-optic Raman spectrometer was used to remotely monitor, in real-time, the local temperature and the extent of reaction of a commercial cyanate ester polymer (AroCy L-10). The local temperature was determined by solving the Boltzmann relation governing the intensity ratio of the Raman Stokes and anti-Stokes scattering of a reference mode which does not vary with the reaction chemistry. The extent of the reaction can be monitored using either individual peaks assciated with the reactant or product or by using the entire spectrum and principal component multivariate calibration. The use of principal component analysis has distinct advantages over the single-peak method. © 1996 John Wiley & Sons, Inc.     

Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma

Oral cancer often presents with aggressive behavior and a high risk of recurrence and metastasis. For oral squamous cell carcinoma (OSCC), which is the most frequent histological subtype, therapy strategies include surgery, radiation therapy, chemotherapy, immune checkpoint inhibitors, and EGFR inhibitors. Recently, a Trop-2 antibody-drug conjugate (ADC) has been approved in the United States of America for the treatment of advanced triple-negative breast cancer. However, this ADC has also been tested in other solid tumors including head & neck squamous cell carcinoma. The prognostic impact of Trop-2 has already been reported for several cancers. We studied the prognostic influence of Trop-2 protein expression on OSCC patients’ survival. The cohort comprised n = 229 OSCC patients with available archived tumor tissue and corresponding non-neoplastic oral mucosa tissue. Using immunohistochemistry, we investigated Trop-2 expression in both the central and peripheral regions of each tumor and in corresponding non-neoplastic oral mucosa. In patients suffering from OSCC with combined high central and low peripheral Trop-2 expression, five-year overall survival (OS) was 41.2%, whereas 55.6% of OSCC patients who presented lower central and/or higher peripheral tumoral Trop-2 expression were alive after five years (p = 0.075). In multivariate Cox regression, the expression pattern of high central tumoral and lower peripheral Trop-2 expression was significantly correlated with impaired OS (HR = 1.802, 95%-CI: 1.134–2.864; p = 0.013) and recurrence-free survival (RFS) (HR = 1.633, 95%-CI: 1.042–2.560; p = 0.033), respectively, when adjusting for co-variables. Hence, Trop-2 may serve as an independent prognostic biomarker in OSCC. In subsequent studies, the pathophysiological meaning of downregulated Trop-2 expression in the OSCC periphery has to be analyzed.