Integrated solid-state nanopore devices for third generation DNA sequencing

Third generation DNA sequencing relies on monitoring the ionic current blockage during the DNA molecule’s threading through a nanoscale pore.It is still really tough to attain the single base discrimination on a DNA strand by merely analyzing the ionic current due to speedy DNA translocation and low spatial resolution.More integrated configurations are pursued to present versatile comparative dissimilarities of the four bases by enhancing the spatial resolution within a DNA molecule translocation event,such as transverse tunneling current,local potential change,and capacitance oriented voltage resonance.In this mini review,the insight is provided into the status quo on several functionalized techniques and methodologies for DNA sequencing and furthermore concluding remark and outlook are presented.     

DDCMP在电网自动化中的应用

在ＤＤＣＭＰ应用于四川省电网通信实践的基础上，对ＤＤＣＭＰ的工程技术问题进行了评估和分析。     

LaO_x(OH)_y supported platinum catalysts for CO oxidation:Deactivation by formation of lanthanum carbonate

Platinum catalyst for CO oxidation has been studied for decades,due to its high activity and good stability.In this work,we prepared three different lantha num oxide or hydroxide supports(LaO_x(OH)_y),and deposited platinum(Pt) with 0.5 at% via an impregnation approach to synthesize Pt/LaO_x(OH)_y catalysts.However,we find that these catalysts perform a poor stability for the CO oxidation reaction.The fresh and used samples were comprehensively characterized by multiple techniques including power X-ray diffraction(XRD),X-ray absorption fine structure(XAFS),transmission electron microscopy(TEM),temperature-programmed reduction by carbon monoxide(CO-TPR) and thermogravimetric analysis(TGA),to demonstrate that the oxidized platinum atoms or clusters,without any component of Pt-Pt metallic bond,are highly dispersed on the surface of LaO_x(OH)_y.Furthermore,the as-formed lanthanum carbonate(La₂O₂CO₃) during the exposure to ambient circumstances or in the reaction atmosphere of CO+O₂,severely impair the reactivity of Pt/LaO_x(OH)_y.On the basis of the obtained experimental results,we have drawn a conclusion that the oxidized P_tO_x atoms or PtxOy clusters are the active species for CO oxidation,while the formation of lanthanum carbonate is the origin of deactivation on reactivity.     

栀子食用人群栀子苷暴露评估

目的 了解我国居民栀子食用情况,评估我国栀子食用人群栀子苷暴露水平及健康风险。方法 通过文献检索和专项监测收集我国栀子中栀子苷含量数据,结合2019—2022年我国食药物质消费量调查数据,采用简单分布方法和概率评估方法获得我国不同人群通过食用栀子的栀子苷暴露水平及健康风险。结果 我国9省栀子食用率为10.32%,每日食用量均值为0.36 g,高消费人群每日栀子食用量为1.48 g。简单分布评估显示,9省栀子食用人群的栀子苷每日平均暴露量为0.29 mg/kg·BW,高消费人群（P95）栀子苷暴露量为1.28 mg/kg·BW,9省栀子食用人群中有17.20%的居民通过食用栀子的栀子苷暴露量超过其每日可耐受摄入量（TDI,0.386 mg/kg·BW）。河南省食用人群每日平均暴露量最高,为0.54 mg/kg·BW。概率评估结果显示,我国14.70%的栀子食用人群栀子苷暴露量超过TDI,具有潜在健康风险。结论 我国栀子食用人群的栀子苷暴露风险总体较低,但部分高消费人群（P95）存在健康风险。     

Unsourced Multiple Access for 6G Massive Machine Type Communications

Unsourced multiple access(UMA) is a multi-access technology for massive, low-power, uncoordinated, and unsourced Machine Type Communication(MTC) networks. It ensures transmission reliability under the premise of high energy efficiency.Based on the analysis of the 6G MTC key performance indicators(KPIs) and scenario characteristics,this paper summarizes its requirements for radio access networks. Following this, the existing multiple access models are analyzed under these standards to determine U...     

大行程位移台干涉测距系统的误差补偿

双频激光干涉仪作为常用的精密光学非接触式测量设备,具有精度高、抗干扰能力强、灵活性好等优点。然而环境温度变化、机械振动等因素可能会影响其测量结果的准确性,并且影响程度会随着测量光程的增加而增大。针对基于双频激光干涉仪的大行程位移台测距系统,首先研究了位移台测距系统的测量原理,然后针对系统存在的各项误差进行了分析和补偿,最后,对系统进行综合误差补偿实验,短时间补偿量达到10^-8 m量级,且时间越长补偿效果越好。该方法较现有的误差补偿方法更为完整,补偿量更大。     

A review on Ti3C2Tx-based nanomaterials:synthesis and applications in gas and humidity sensors

Ti3C2Tx,which is a novel two-dimensional (2D)material,has received enormous interest in the field of sensor technology due to its large surface area,excellent e...     

Collaborative Action of Microglia and Astrocytes Mediates Neutrophil Recruitment to the CNS to Defend against Escherichia coli K1 Infection

Escherichia coli K1 is a leading cause of neonatal bacterial meningitis. Recruitment of neutrophils to the central nervous system (CNS) via local immune response plays a critical role in defense against E. coli K1 infection; however, the mechanism underlying this recruitment remains unclear. In this study, we report that microglia and astrocytes are activated in response to stimulation by E. coli K1 and/or E. coli K1-derived outer membrane vesicles (OMVs) and work collaboratively to drive neutrophil recruitment to the CNS. Microglial activation results in the release of the pro-inflammatory cytokine TNF-α, which activates astrocytes, resulting in the production of CXCL1, a chemokine critical for recruiting neutrophils. Mice lacking either microglia or TNF-α exhibit impaired production of CXCL1, impaired neutrophil recruitment, and an increased CNS bacterial burden. C-X-C chemokine receptor 2 (CXCR2)-expressing neutrophils primarily respond to CXCL1 released by astrocytes. This study provides further insights into how immune responses drive neutrophil recruitment to the brain to combat E. coli K1 infection. In addition, we show that direct recognition of E. coli K1 by microglia is prevented by the K1 capsule. This study also reveals that OMVs are sufficient to induce microglial activation.     

四川盆地剑阁地区多层系储层叠前描述

近期龙岗62井长兴组及剑门102井须家河组须三段获得重大突破,证实长兴组生物礁储层及须家河组碎屑岩储层均具有较大的勘探潜力。通过对研究区资料特征进行分析对比,在攻关中采用了纵横波阻抗叠前同时反演、体曲率属性、瞬时振幅属性等针对性技术,准确地刻画了生物礁台缘发育相带,预测了碎屑岩裂缝发育和油气有利聚集区,为研究区下一步井位部署提供了准确的资料基础,并形成了一套有效的技术流程。