Jin Seok  Sujin Jun  Jung Ok Lee  Gi Jin Kim 《International journal of molecular sciences》2020,21(22)

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Ji-Youn Kim  Chang-Hyeon An  Jae-Young Kim  Jae-Kwang Jung 《International journal of molecular sciences》2020,21(22)

Salivary secretory disorders are life-disrupting pathologic conditions with a high prevalence, especially in the geriatric population. Both patients and clinicians frequently feel helpless and get frustrated by the currently available therapeutic strategies, which consist mainly of palliative managements. Accordingly, to unravel the underlying mechanisms and to develop effective and curative strategies, several animal models have been developed and introduced. Experimental findings from these models have contributed to answer biological and biomedical questions. This review aims to provide various methodological considerations used for the examination of pathological fundamentals in salivary disorders using animal models and to summarize the obtained findings. The information provided in this review could provide plausible solutions for overcoming salivary disorders and also suggest purpose-specific experimental animal systems.  相似文献   

    

Eva-Maria Herrlinger  Mirjam Hau  Dr. Desiree Melanie Redhaber  Dr. Gabriele Greve  Dr. Dominica Willmann  Simon Steimle  Prof. Dr. Michael Müller  Prof. Michael Lübbert  Dr. Christoph Cornelius Miething  Prof. Roland Schüle  Prof. Manfred Jung 《Chembiochem : a European journal of chemical biology》2020,21(16):2329-2347

Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site-specific LSD1 inhibition, we developed an enzyme-prodrug system with the bacterial nitroreductase NfsB (NTR) that was expressed in the virally transfected AML cell line THP1-NTR⁺. The cellular activity of the NTR was proven with a new luminescent NTR probe. We synthesised a diverse set of nitroaromatic prodrugs that by design do not affect LSD1 and are reduced by the NTR to release an active LSD1 inhibitor. The emerging side products were differentially analysed using negative controls, thereby revealing cytotoxic effects. The 2-nitroimidazolyl prodrug of a potent LSD1 inhibitor emerged as one of the best prodrug candidates with a pronounced selectivity window between wild-type and transfected THP1 cells. Our prodrugs are selectively activated and release the LSD1 inhibitor locally, proving their suitability for future targeting approaches.  相似文献   

    

Su‐Kyo Jung  Jin Hyuck Heo  Byeong M. Oh  Jong Bum Lee  Sung‐Ha Park  Woojin Yoon  Yunmi Song  Hoseop Yun  Jong H. Kim  Sang Hyuk Im  O‐Pil Kwon 《Advanced functional materials》2020,30(13)

A series of chiral stereoisomers of electron transporting materials with two chiral substituents is rationally designed and synthesized, and the influence of stereoisomerism on their physical and electronic properties is investigated to demonstrate highly efficient and stable perovskite solar cells (PSCs). Compared to mesomeric naphthalene diimide (NDI) derivatives, which have heterochiral side groups with centrosymmetric molecular packing of symmetric‐shaped conformers in the crystalline state, enantiomeric NDI derivatives have homochiral side groups that exhibit non‐centrosymmetric molecular packing of asymmetric‐shaped conformers in the crystalline state and exhibit better solution processability based on one order of magnitude higher solubility. A similar trend is observed in different rylene diimide stereoisomers based on larger semiconducting core perylene diimide. The PSCs based on NDI enantiomers with good film‐forming ability and a very high lowest phase transition temperature (T_lowest) of 321 °C exhibit a high and uniform average power conversion efficiency (PCE) of 19.067 ± 0.654%. These PSCs also have a high temporal device stability, with less than 10% degradation of the PCE at 100 °C for 1000 h without encapsulation. Therefore, chiral stereoisomer engineering of charge transporting materials is a potential approach to achieve high solution processability, excellent performance, and significant temporal stability in organic electronic devices.  相似文献   

    

Moran Balaish  Ji‐Won Jung  Il‐Doo Kim  Yair Ein‐Eli 《Advanced functional materials》2020,30(18)

This review reports on the most updated technological aspects of Li–air battery cathode materials. It provides the reader with recent developments, alongside critical views. The requirements for air‐cathodes, as well as the classification and characterization of carbon‐based and carbon‐free air cathodes, are listed. The effects of two major substituent groups of materials, namely carbon and advanced materials (metals, metal‐oxides, metal‐carbides, and metal‐nitrides) aimed at replacing carbon, are discussed in terms of their chemical and electrochemical stability. The report covers aspects of surface chemistry and structure influence on the electrolyte and discharge products stability. The review also reports on the efforts to suppress side reactions and deterioration of the polymeric binders (if a composite electrode is being considered). This is recognized as a means to enhance Li–air battery performance. The report concludes with an outlook and perspective, providing the readers with some insight on other factors and their impact on the long road toward a viable air‐cathode suitable for Li–air battery operations.  相似文献   

    

In‐Hwan Ahn  Seon Ju Yeo  Kinam Jung  Gumin Kang  Dong‐Hun Shin  Ho Seong Jang  Byunghoon Kim  Minwoo Nam  Seok Joon Kwon  Doo‐Hyun Ko 《Advanced functional materials》2020,30(13)

Upconversion nanoparticles (UCNPs) have been integrated with photonic platforms to overcome the intrinsically low quantum efficiency limit of upconversion luminescence (UCL). However, platforms based on thin films lack transferability and flexibility, which hinders their broader and more practical application. A plasmonic structure is developed that works as a multi‐functional platform for flexible, transparent, and washable near‐infrared (NIR)‐to‐visible UCL films with ultra‐strong UCL intensity. The platform consists of dielectric microbeads decorated with plasmonic metal nanoparticles on an insulator/metal substrate. Distinct improvements in NIR confinement, visible light extraction, and boosted plasmonic effects for upconversion are observed. With weak NIR excitation, the UCL intensity is higher by three orders of magnitude relative to the reference platform. When the microbeads are organized in a square lattice array, the functionality of the platform can be expanded to wearable and washable UCL films. The platform can be transferred to transparent, flexible, and foldable films and still emit strong UCL with a wide viewing angle.  相似文献   

    

Junyoung Kim  Jaewoo Lee  Jonghyeok Yun  Seung Hyun Choi  Sang A Han  Janghyuk Moon  Jung Ho Kim  Jong‐Won Lee  Min‐Sik Park 《Advanced functional materials》2020,30(15)

Lithium (Li) metal is regarded as the most attractive anode material for high‐energy Li batteries, but it faces unavoidable challenges—uncontrollable dendritic growth of Li and severe volume changes during Li plating and stripping. Herein, a porous carbon framework (PCF) derived from a metal–organic framework (MOF) is proposed as a dual‐phase Li storage material that enables efficient and reversible Li storage via lithiation and metallization processes. Li is electrochemically stored in the PCF upon charging to 0 V versus Li/Li⁺ (lithiation), making the PCF surface more lithiophilic, and then the formation of metallic Li phase can be induced spontaneously in the internal nanopores during further charging below 0 V versus Li/Li⁺ (metallization). Based on thermodynamic calculations and experimental studies, it is shown that atomically dispersed zinc plays an important role in facilitating Li plating and that the reversibility of Li storage is significantly improved by controlled nanostructural engineering of 3D porous nanoarchitectures to promote the uniform formation of Li. Moreover, the MOF‐derived PCF does not suffer from macroscopic volume changes during cycling. This work demonstrates that the nanostructural engineering of porous carbon structures combined with lithiophilic element coordination would be an effective approach for realizing high‐capacity, reversible Li‐metal anodes.  相似文献   

    

Yu‐Hsiang Chang  Chia‐Wei Ku  Yi‐Hua Zhang  Hsiang‐Chen Wang  Jung‐Yao Chen 《Advanced functional materials》2020,30(21)

The exotic photophysical properties of organic–inorganic hybrid perovskite with long exciton lifetimes and small binding energy have appeared as promising front‐runners for next‐generation non‐volatile flash photomemory. However, the long photo‐programming time of photomemory limits its application on light‐fidelity (Li‐Fi), which requires high storage capacity and short programming times. Herein, the spatially addressable perovskite in polystyrene‐block‐poly(ethylene oxide) (PS‐b‐PEO)/perovskite composite film as an photoactive floating gate is demonstrated to elucidate the effect of morphology on the photo‐responsive characteristics of photomemory. The chelation between lead ion and PEO segment promotes the anti‐solvent functionalities of the perovskite/PS‐b‐PEO composite film, thus allowing the solution‐processable poly(3‐hexylthiophene‐2,5‐diyl) (P3HT) to act as the active channel. Through manipulating the interfacial area between perovskite and P3HT, fast photo‐induced charge transfer rate of 0.056 ns^?1, high charge transfer efficiency of 89%, ON/OFF current ratio of 10⁴, and extremely low programming time of 5 ms can be achieved. This solution‐processable and fast photo‐programmable non‐volatile flash photomemory can trigger the practical application on Li‐Fi.  相似文献   

    

Tengfei Qiu  Bin Luo  Eser Metin Akinoglu  Jung‐Ho Yun  Ian R. Gentle  Lianzhou Wang 《Advanced functional materials》2020,30(31)

Metallic mesh materials are promising candidates to replace traditional transparent conductive oxides such as indium tin oxide (ITO) that is restricted by the limited indium resource and its brittle nature. The challenge of metal based transparent conductive networks is to achieve high transmittance, low sheet resistance, and small perforation size simultaneously, all of which significantly relate to device performances in optoelectronics. In this work, trilayer dielectric/metal/dielectric (D/M/D) nanomesh electrodes are reported with precisely controlled perforation size, wire width, and uniform hole distribution employing the nanosphere lithography technique. TiO₂/Au/TiO₂ nanomesh films with small hole diameter (≤700 nm) and low thickness (≤50 nm) are shown to yield high transmittance (>90%), low sheet resistance (≤70 Ω sq^?1), as well as outstanding flexural endurance and feasibility for large area patterning. Further, by tuning the surface wettability, these films are applied as easily recyclable flexible electrodes for electrochromic devices. The simple and cost‐effective fabrication of diverse D/M/D nanomesh transparent conductive films with tunable optoelectronic properties paves a way for the design and realization of specialized transparent electrodes in optoelectronics.  相似文献   

    

Jinwoo Lee  Heayoun Sul  Yeongju Jung  Hyeonseok Kim  Seonggeun Han  Joonhwa Choi  Jaeho Shin  Dongkwan Kim  Jinwook Jung  Sukjoon Hong  Seung Hwan Ko 《Advanced functional materials》2020,30(36)

Cephalopods’ extraordinary ability to hide into any background has inspired researchers to reproduce the intriguing ability to readily camouflage in the infrared (IR) and visible spectrum but this still remains as a conundrum. In this study, a multispectral imperceptible skin that enables human skin to actively blend into the background both in the IR‐visible integrated spectrum only by simple temperature control with a flexible bi‐functional device (active cooling and heating) is developed. The thermochromic layer on the outer surface of the device, which produces various colors based on device surface temperature, expands the cloaking range to the visible spectrum (thus visible‐to‐IR) and ultimately completes day‐and‐night stealth platform simply by controlling device temperature. In addition, the scalable pixelization of the device allows localized control of each autonomous pixel, enabling the artificial skin surface to adapt to the background of the sophisticated pattern with higher resolution and eventually heightening the level of imperceptibility. As this proof‐of‐concept can be directly worn and conceals the human skin in multispectral ranges, the work is expected to contribute to the development of next‐generation soft covert military wearables and perhaps a multispectral cloak that belongs to cephalopods or futuristic camouflage gadgets in the movies.  相似文献