Fabrication of high hardness Ni mold with electroless nickel–boron thin layer

The nickel electroforming method using a high-concentration nickel sulfamate bath is commonly used to fabricate micro metal molds in the LIGA process; however, this method does not produce micro metal molds of sufficient hardness. One means of improving the hardness of micro metal molds made using the nickel electroforming method is to include additives in the nickel plating solution. Another method is nickel alloy plating or a similar technique. In this research, we used a nickel–boron (Ni–B) electroless alloy plating method to obtain a hard nickel plated film having hardness of 832 Hv. It was also ascertained that Ni–B electroless alloy plated film retains its high hardness even during heat treatment in conditions of 250°C for 1 h. To deal with the high stresses developed in high-hardness plated films, we proposed double-layer nickel electroforming. This method is covered and used on conventional nickel electroforming layer by high hardness micro mold. High hardness micro metal mold using double-layer was fabricated by nickel electroforming and Ni–B electroless alloy plating method.     

Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics

Purpose : We aimed to identify novel chemotherapy responsiveness biomarkers for osteosarcoma (OS) by investigating the global protein expression profile of 12 biopsy samples from OS patients. Experimental design : Six patients were classified as good responders and six as poor responders, according to the Huvos grading system. The protein expression profiles obtained by 2‐D DIGE consisted of 2250 protein spots. Results : Among them, we identified 55 protein spots whose intensity was significantly different (Bonferroni adjusted p‐value<0.01) between the two patient groups. Mass spectrometric protein identification demonstrated that the 55 spots corresponded to 38 distinct gene products including peroxiredoxin 2 (PRDX 2). Use of a specific antibody against PRDX 2 confirmed the differential expression of PRDX 2 between good and poor responders, while PRDX 2 levels as measured by Western blotting correlated highly with their corresponding 2‐D DIGE values. The predictive value of PRDX 2 expression was further confirmed by examining an additional four OS cases using Western blotting. Conclusions and clinical relevance : These results establish PRDX 2 as a candidate for chemotherapy responsiveness marker in OS. Measuring PRDX 2 in biopsy samples before treatment may contribute to more effective management of OS.     

Effects of 4He impurities on 3He nuclear spin-lattice relaxation in hcp solid 3He

Nuclear spin-lattice relaxation properties of hcp solid ³He with ⁴He impurities have been studied. At temperatures below the exchange plateau region, three kinds of relaxation time were observed. To analyze the data, a phenomenological four-bath model was developed, the four baths being the Zeeman bath, the phonon bath, an X-bath, and a Y-bath. The X-bath consists of the exchange bath and a part of the ⁴He-⁴He elastic interaction bath. The Y-bath is the main part of the elastic interaction bath. We measured the concentration dependence of the energy constants of all the baths, as well as the temperature and concentration dependences of the three kinds of relaxation time. The relaxation behavior corresponding to the process between the X-bath and the Y-bath could not be expressed by a single exponential function of time and the relaxation rate was strongly dependent on the concentration. This process may be related to the internal thermal equilibrium process within the elastic interaction bath. The impurity-dependent relaxation time between the X-bath and the phonon bath had a temperature dependence of T ^–n with n = 7.4±0.3.     

Dynamic alternation of primate response properties during trial-and-error knowledge updating

Humans and animals seek appropriate solutions to novel problems through trial-and-error (TE) actions and observation of their outcomes. Once an individual has obtained the knowledge (rule) to solve a problem, knowledge-based (KB) actions may be applied in a stereotypical manner. Solutions can thus be based on TE or KB actions. To characterize this learning process at the behavioral level, we developed a new cognitive task for a laboratory monkey (Macaca fuscata) to perform. In this task, a search array consisting of six elements of different colors was presented, one of which was the behaviorally relevant target. The target color was changed unpredictably with no instruction or signal, requiring the monkey to use a TE search strategy to find the target color. We found that once the monkey identified the relevant color by chance after a color change, correct performance increased in a step-like manner and at the same time, other response properties (reaction time and color-choice tendency) also changed discontinuously. These step-like alternations in behavioral performance may be attributed to the subject’s switching between TE and KB search strategies in the two phases. The present study has therefore provided behavioral evidence for the timing and manner of switching between search strategies during the process of updating knowledge.     

Analysis of accelerated creep under constant sustaining load for austenitic stainless steels

The effect of stress on creep rate of austenitic stainless steels of type 347 and 316 was studied by applying the differential test technique. It was found that the creep rate could be expressed as follows, whereB ₁ is a material constant depending on temperature,a ₁ anda _o are constants, and σ is the real stress. Considering the increase in real stress during creep process due to void formation and to the decrease in cross sectional area of the specimen, integrating the above equation yields the following creep curve, 1 $$ \in = \in _m + \frac{1}{{n_o \left( {c_o + 1} \right)}}ln\frac{1}{{1 - n_o \left( {c_o + 1} \right) \in _m (t - t_{_m } )}}$$ where ∈ is the creep strain at a given time (t), ∈_m is the minimum creep rate, ∈_m andt _m are the strain and time, respectively, at the minimum creep rate,n _o is a constant, andc _o is the material constant relating to the void formation. This equation agrees very well with the experimental creep curve.     

A rate-dependent cohesive model for simulating dynamic crack propagation in brittle materials

Numerical investigations are conducted to simulate high-speed crack propagation in pre-strained PMMA plates. In the simulations, the dynamic material separation is explicitly modeled by cohesive elements incorporating an initially rigid, linear-decaying cohesive law. Initial attempts using a rate-independent cohesive law failed to reproduce available experimental results as numerical crack velocities consistently overestimate experimental observations. As proof of concept, a phenomenological rate-dependent cohesive law, which bases itself on the physics of microcracking, is introduced to modulate the cohesive law with the macroscopic crack velocity. We then generalize this phenomenological approach by establishing a rate-dependent cohesive law, which relates the traction to the effective displacement and rate of change of effective displacement. It is shown that this new model produces numerical results in good agreement with experimental data. The analysis demonstrates that the simulation of high-speed crack propagation in brittle structures necessitates the use of rate-dependent cohesive models, which account for the complicated rate-process of dynamic fracture at the propagating crack tip.     

Comparisons of optimal release policies for software systems

In a software product management, it is an important problem to determine the optimal release timing which minimizes the total expected cost incurred in both testing and operation phases. In this paper, we compare the performance between two kinds of software release methods, which are referred to as the T-policy and the N-policy. Based on the existing software reliability growth models, we formulate the expected cost functions and derive analytically the optimal policies under these control methods. Also, we derive a criterion for which control methods should be adopted. Finally, in numerical examples, we calculate the optimal release policies for several cost parameters.     

Parallel processing circuit of line image using neuristor

A simultaneous detecting circuit system of centers and lengths of some lines in one dimension is presented applying an electronic circuit model of the nervous axon with respect to signal transmission. This model consists of series of one basic section, and has functions of Neuristor. The circuit system has a paralell processing function. It is constructed by three layers. In the first layer each visual signal of lines is changed to electric pulse signal. In the second layer edges of each line are detected, and in the third layer these detected signals are converted into voltages which correspond to lengths of the lines. These functions were confirmed experimentally using its hardware.     

Identification of charge‐transfer transition between Gd3+ to O2− in gadolinium‐containing oxide phosphors in VUV region

Abstract— The broad bands at around 155 nm for GdAl₃(BO₃)₄:Eu, at 184 nm for Ca₄GdO(BO₃)₃:Eu, at 183 nm for Gd₂SiO₅:Eu, and at 170 nm for GdAlO₃:Eu were observed. These bands were assigned to the charge‐transfer (CT) transition of Gd³⁺‐O^2?. In the excitation spectrum of (Gd,Y)BO₃:Eu, a broadened excitation band was observed in VUV region. It could be considered that this band was composed of two bands at about 160 and 166 nm. The preceding band was assigned to the BO₃ group absorption. The later one at about 166 nm could be assigned to the CT transition of Gd³⁺‐O^2?, according to the result of GdAl₃(BO₃)₄:Eu, Ca₄GdO(BO₃)₃:Eu, Gd₂SiO₅:Eu, and GdAlO₃:Eu. The excitation spectra overlapped between the CT transition of Gd³⁺‐O^2? and BO₃ groups absorption. It caused the emission of Eu³⁺ to take place effectively in the trivalent europium‐doped (Gd,Y)BO₃ host lattice under 147‐nm excitation.