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排序方式: 共有4585条查询结果,搜索用时 13 毫秒
31.
Kazuko Satake Ai Katayama Hideki Ohkoshi Takeshi Nakahara Takashi Takeuchi 《Sensors and actuators. B, Chemical》1994,20(2-3):111-117
Oxide semiconductors have been examined to develop NOx sensors for exhaust monitoring. Titania doped with trivalent elements, such as Al3+, Sc3+, Ga3+ or In3+, has a good sensitivity and selectivity to NO between 450 and 550 °C, and shows rapid response. A sensor probe for monitoring exhaust NOx has been fabricated. Many kinds of interference gases, such as C3H6, CO and SO2, have been found to have only a slight influence on the sensor response to NO. The influence of O2 and H2O is also negligible, except for the cases of 0% H2O and fuel-rich conditions. In accordance with these results, the sensor probe operates satisfactority in the exhaust gas of various combustion conditions without interference from the various kinds of gas species in the exhaust gases. 相似文献
32.
Rod-shaped BaTiO3 powder particles have been prepared from rod-shaped TiO2 ·nH2O and BaCO3 in molten chloride. The morphology of BaTiO3 particles was studied referring to the effects of the chemical species of the starting titanium compound, amount of chloride, particle size of the titanium compound and reaction conditions, and the preparation condition of rod-shaped BaTiO3 has been determined: i.e., large TiO2 ·nH2O particles were heated at 700°C in molten salt with an equal amount of BaTiO3. This condition was effective in suppressing the formation of BaTiO3 by a solution-precipitation process as well as the deformation of either TiO2 ·nH2O or BaTiO3, which are responsible for the formation of equiaxed BaTiO3 particles. The obtained rod-shaped BaTiO3 particles had a cubic symmetry. Electron diffraction analysis showed that the following topotactic relation is retained; 0 1 0potassium tetratitanate 0 1 0hydrated titania 1 0 0anatase 1 0 0barium titanate 相似文献
33.
Takashi Ogihara Tadashi Ikemoto Nobuyasu Mizutani Masanori Kato Yukuaki Mitarai 《Journal of Materials Science》1986,21(8):2771-2774
The Ta2O5 powders synthesized by the hydrolysis of tantalum pentaethoxide, Ta(OC2H5)5 in alcoholic solution were monodispersed fine oxide particles, which were a uniform, spherical shape, non-agglomerate, and had a narrow size distribution. They grew to 1.2m after ageing for 1 h after hydrolysis. Powder X-ray diffraction and differential thermal analysisthermogravimetric analysis showed the particles were amorphous and hydrated. These particles lost the water at 290° C and gave well-crystalline Ta2O at 740° C. Throughout these thermal processes, the particle morphology was kept almost the same. 相似文献
34.
Takashi Hayashi Makoto Mihoya Iwao Yamai Hajime Saito Shin-Ichi Hirano 《Journal of Materials Science》1987,22(4):1305-1309
Needle-like or wool-like Al2O3 whiskers can be grown on a substrate by the hydrolysis of aluminium fluoride vapour. Effects of the growth conditions on the morphology of the crystals and growth processes of the whisker were investigated, and the optimum growth condition of whiskers was examined. Adequate vapour pressure conditions of the reactant gases for the growth of the wool-like whisker were found to be
. Aluminium oxyfluoride was assumed to be the most probable intermediate species for the growth of Al2O3 whiskers. A variety of crystal morphologies are also shown and described with respect to the experimental conditions. 相似文献
35.
Mio Yamaguchi Kiyoshi Takagi Koki Narita Yasuhiro Miki Yoshiaki Onodera Minoru Miyashita Hironobu Sasano Takashi Suzuki 《International journal of molecular sciences》2021,22(4)
Chemokines secreted from stromal cells have important roles for interactions with carcinoma cells and regulating tumor progression. C-C motif chemokine ligand (CCL) 5 is expressed in various types of stromal cells and associated with tumor progression, interacting with C-C chemokine receptor (CCR) 1, 3 and 5 expressed in tumor cells. However, the expression on CCL5 and its receptors have so far not been well-examined in human breast carcinoma tissues. We therefore immunolocalized CCL5, as well as CCR1, 3 and 5, in 111 human breast carcinoma tissues and correlated them with clinicopathological characteristics. Stromal CCL5 immunoreactivity was significantly correlated with the aggressive phenotype of breast carcinomas. Importantly, this tendency was observed especially in the CCR3-positive group. Furthermore, the risk of recurrence was significantly higher in the patients with breast carcinomas positive for CCL5 and CCR3 but negative for CCR1 and CCR5, as compared with other patients. In summary, the CCL5-CCR3 axis might contribute to a worse prognosis in breast cancer patients, and these findings will contribute to a better understanding of the significance of the CCL5/CCRs axis in breast carcinoma microenvironment. 相似文献
36.
Dr. Daisuke Okuno Dr. Noriho Sakamoto Dr. Mohammed S. O. Tagod Yoshiko Akiyama Dr. Sakiko Moriyama Dr. Takuto Miyamura Dr. Atsuko Hara Dr. Takashi Kido Dr. Hiroshi Ishimoto Prof. Yuji Ishimatsu Prof. Takashi Tanaka Prof. Jun Ishihara Prof. Kohsuke Takeda Prof. Yoshimasa Tanaka Prof. Hiroshi Mukae 《ChemMedChem》2021,16(16):2515-2523
Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, is causally related to fibrotic diseases, including idiopathic pulmonary fibrosis. The identification of Compounds that interfere with the HSP47-collagen interaction is essential for the development of relevant therapeutics. Herein, we prepared human HSP47 as a soluble fusion protein expressed in E. coli and established an assay system for HSP47 inhibitor screening. We screened a natural and synthetic Compound library established at Nagasaki University. Among 1023 Compounds, 13 exhibited inhibitory activity against human HSP47, of which three inhibited its function in a dose-dependent manner. Epigallocatechin-3-O-gallate, one of these three Compounds, is a typical polyphenol Compound derived from tea leaves. Structurally related Compounds were synthesized and examined for their activity, revealing a hydroxyl group at A-ring position 5 as important for its activity. The present findings provide valuable insight for the development of natural product-derived therapeutics for fibrotic diseases, including idiopathic pulmonary fibrosis. 相似文献
37.
Gaku Yamanaka Shinichiro Morichi Tomoko Takamatsu Yusuke Watanabe Shinji Suzuki Yu Ishida Shingo Oana Takashi Yamazaki Fuyuko Takata Hisashi Kawashima 《International journal of molecular sciences》2021,22(9)
Accumulating evidence has demonstrated that the pathogenesis of epilepsy is linked to neuroinflammation and cerebrovascular dysfunction. Peripheral immune cell invasion into the brain, along with these responses, is implicitly involved in epilepsy. This review explored the current literature on the association between the peripheral and central nervous systems in the pathogenesis of epilepsy, and highlights novel research directions for therapeutic interventions targeting these reactions. Previous experimental and human studies have demonstrated the activation of the innate and adaptive immune responses in the brain. The time required for monocytes (responsible for innate immunity) and T cells (involved in acquired immunity) to invade the central nervous system after a seizure varies. Moreover, the time between the leakage associated with blood–brain barrier (BBB) failure and the infiltration of these cells varies. This suggests that cell infiltration is not merely a secondary disruptive event associated with BBB failure, but also a non-disruptive event facilitated by various mediators produced by the neurovascular unit consisting of neurons, perivascular astrocytes, microglia, pericytes, and endothelial cells. Moreover, genetic manipulation has enabled the differentiation between peripheral monocytes and resident microglia, which was previously considered difficult. Thus, the evidence suggests that peripheral monocytes may contribute to the pathogenesis of seizures. 相似文献
38.
Sachi Oshima Shunichi Asai Naohiko Seki Chikashi Minemura Takashi Kinoshita Yusuke Goto Naoko Kikkawa Shogo Moriya Atsushi Kasamatsu Toyoyuki Hanazawa Katsuhiro Uzawa 《International journal of molecular sciences》2021,22(12)
We identified the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) tissues by RNA sequencing, in which 168 miRNAs were significantly upregulated, including both strands of the miR-31 duplex (miR-31-5p and miR-31-3p). The aims of this study were to identify networks of tumor suppressor genes regulated by miR-31-5p and miR-31-3p in HNSCC cells. Our functional assays showed that inhibition of miR-31-5p and miR-31-3p attenuated cancer cell malignant phenotypes (cell proliferation, migration, and invasion), suggesting that they had oncogenic potential in HNSCC cells. Our in silico analysis revealed 146 genes regulated by miR-31 in HNSCC cells. Among these targets, the low expression of seven genes (miR-31-5p targets: CACNB2 and IL34; miR-31-3p targets: CGNL1, CNTN3, GAS7, HOPX, and PBX1) was closely associated with poor prognosis in HNSCC. According to multivariate Cox regression analyses, the expression levels of five of those genes (CACNB2: p = 0.0189; IL34: p = 0.0425; CGNL1: p = 0.0014; CNTN3: p = 0.0304; and GAS7: p = 0.0412) were independent prognostic factors in patients with HNSCC. Our miRNA signature and miRNA-based approach will provide new insights into the molecular pathogenesis of HNSCC. 相似文献
39.
While reuse is an effective lifecycle option in terms of reduction of environmental loads and value of reutilization, reuse has inherent difficulties. Our naive question is why component reuse of home appliances seems impossible while that of photocopiers succeeded. This paper clarifies an essential factor for successful reuse; that is, the balance between supply and demand of reusables, and proposes an index named ‘marginal reuse rate,’ which indicates upper limit of reusability. By using this index, reusability of several products is analyzed. The marginal reuse rate indicates that design of lifecycle, in addition to product design, is indispensable for successful reuse. 相似文献
40.
Yttria (Y2O3) films were prepared at high deposition rates of up to 83 nm/s (300 μm/h) by laser chemical vapor deposition (LCVD) using an Y(dpm)3 precursor. The effects of deposition conditions, mainly total gas pressure and laser power, on morphology, deposition rate and preferred orientation were studied. Plasma was produced around the substrate over a critical laser power resulting in significant increases in deposition temperature and deposition rate. The high deposition rate (300 μm/h) by LCVD was about 100 to 1000 times as high as those by conventional CVD. The morphology of Y2O3 films changed from faceted and columnar structures with high (400) orientation to a columnar structure with high (440) orientation, and finally to a cone-like structure with moderate (440) orientation with increasing total gas pressure (Ptot). 相似文献