Evaluation of dynamic density by simultaneous measurement of ultrasonic velocity and elastic modulus under oscillatory deformation

It is proposed that dynamic density can be estimated from simultaneous measurements of ultrasonic velocity and modulus under an oscillatory deformation. An experimental investigation was carried out and a theoretical model applied. Preliminary experiments show that measurement of the dynamic density is a major aid to the study of plastic deformation.     

Left heart bypass using the oscillated blood flow with totally implantable vibrating flow pump

Palliative care was initiated in Italy towards the end of the 1970s, mainly through the efforts of Professor Ventafridda and his colleagues. This article describes some of the most important steps made in this country to gain widespread acceptance for the principles and practice of palliative care. After about 15 years the Italian situation is still confusing. While some Regions have made progress, others are far from reaching even minimal goals. The efforts of many charities and of the Italian Society for Palliative Care and the Italian School for Palliative Medicine, have been huge, but still not sufficient to promote widespread involvement of the National Health Authorities. In the absence of clear Regional and central laws, the recent changes in the Italian health system combined with increasing financial difficulties threaten the advances already made.     

A 1.6-GB/s data-rate 1-Gb synchronous DRAM with hierarchicalsquare-shaped memory block and distributed bank architecture

This paper describes key techniques for a 1.6-GB/s high data-rate 1-Gb synchronous DRAM (SDRAM). Its high data transfer rate and large memory capacity are targeted to the advanced unified memory system in which a single DRAM (array) is used as both the main memory and the three-dimensional (3-D) graphics frame memory in a time sharing fashion. The 200-MHz high-speed operation is achieved by the unique hierarchical square-shaped memory block (SSMB) layout and the novel distributed bank (D-BANK) architecture. A 0.29 μm² cell and 581.8 mm² small die area are achieved using 0.15-μm CMOS technology. The ×61 chip uses 196-pin BGA type chip-scale-package (CSP). Implementation of a built-in self-test (BIST) circuit with a margin test capability is also described     

Relationship between glomerular epithelial cell injury and proteinuria in IgA nephropathy

The cost of in-hospital percutaneous transluminal coronary angioplasty (PTCA) has risen since the introduction of the coronary stent. Increased attention is now being given to the PTCA charges in Japan and a multicenter study is necessary with regard to in-hospital charges. To clarify the differences in in-hospital charges for PTCA with and without coronary stent [Stent Group and plain old balloon angioplasty (POBA) Group, respectively], we studied the PTCA charges of 352 patients in 6 hospitals. Age, male gender and extent of coronary artery disease were not different. The ratio of acute myocardial infarction ranged from 16% to 64% and that of coronary stenting ranged from 24% to 65% (p < 0.001). In-hospital charge ranged from 1.4 +/- 0.8 to 2.2 +/- 1.0 million yen (p < 0.0001). The procedural charge accounted for 53% to 75% of the in-hospital charge (p < 0.01). The in-hospital charge ranged from 1.6 +/- 0.7 to 3.3 +/- 1.6 million yen in the Stent Group, higher than the charge of 1.1 +/- 0.8 to 1.9 +/- 0.7 million yen in the POBA Group (p < 0.0001). There was a statistical difference in the number of balloon catheters used (1.1 +/- 0.4 to 2.1 +/- 0.9, p < 0.005) but not in the mean number of stents used (1.1 +/- 0.3 to 1.4 +/- 0.7). The procedural charge of the institutes with higher stenting rate (> 45%) seemed to be lower than that of the institutes with lower stenting rate (p < 0.02). In conclusion, there are large variation between institutions in PTCA charges, and in-hospital charges increased with the use of stents on introduction of the Diagnosis Related Group used in the United States. We should charge separately for coronary stenting and POBA. Despite any initial increase in the in-hospital charge for coronary stenting compared to POBA, successful stent implantation will result in a superior saving in procedural charges.     

Structural changes and cell properties of human ovarian surface epithelium in ovarian pathophysiology

The surface epithelial cells of the ovary, which are modified peritoneal cells, form a single, focally pseudostratified layer. The Müllerian ducts differentiate after invagination of the coelomic mesothelium over the gonadal ridges during the 6th week of embryonic life. On the basis of the embryologically putative Müllerian potential of this epithelium, endometriosis can be explained by coelomic metaplasia from the peritoneum, including ovarian surface epithelium. Some pelvic endometriosis specimens have shown that epithelial cells on the ovary or pelvis are serially changed to endometriotic gland cells. Immunohistochemistry as well as scanning electron microscopy also reinforce the light-microscopical findings. A three-dimensional culture system demonstrated that human ovarian surface epithelial cells exhibited a glandular-stromal structure when they were cocultured with endometrial stromal cells in an estrogen-rich environment. Ovarian carcinomas in the epithelial-stromal category are thought to arise from the surface epithelium and its inclusions. The ovarian surface epithelium is physiologically involved in follicular rupture, oocyte release, and the subsequent repair of follicle wall during reproductive age. Simultaneously, ovulation may cause a loss of integrity of the surface epithelium, followed by accumulation of multiple mutations. The cortical invagination, surface stromal proliferation, and Müllerian differentiation of these cells are likely not to be an early step in the cancer development. However, the inclusion cysts are closely related with carcinogenesis because they are significantly more common in ovaries contralateral to those containing epithelial cancers than in control ovaries. As an in vitro study, ovarian carcinoma cell lines were established from simian virus 40 large T antigen-transformed human surface epithelial cells of the ovary. Further investigations of these cell lines may lead to insights into the preneoplastic and early stages of carcinomas. To clarify the pathogenesis of endometriosis and epithelial ovarian cancer, specifically designed studies of ovarian surface epithelium are required.     

Preparation of carbon microcoils by catalytic methane hot-wire CVD process

Three-dimensional (3D) double-helix carbon microcoils (CMCs) were synthesized by the catalytic pyrolysis of methane using Ni catalyst in various hot-wire CVD processes. The most effective process is: using preheating method, in which methane was preheated at 1500 °C in a upper reaction tube by a hot wire, and chemical vapor deposition of carbon then occurred at 700-750 °C in a lower reaction tube, where CMCs were synthesized. The growth morphologies and microstructure were examined and compared with the conventional CMCs grown by acetylene catalytic pyrolysis.     

Giant spin Hall effect in perpendicularly spin-polarized FePt/Au devices

Conversion of charge current into pure spin current and vice versa in non-magnetic semiconductors or metals, which are called the direct and inverse spin Hall effects (SHEs), provide a new functionality of materials for future spin-electronic architectures. Thus, the realization of a large SHE in a device with a simple and practical geometry is a crucial issue for its applications. Here, we present a multi-terminal device with a Au Hall cross and an FePt perpendicular spin injector to detect giant direct and inverse SHEs at room temperature. Perpendicularly magnetized FePt injects or detects perpendicularly polarized spin current without magnetic field, enabling the unambiguous identification of SHEs. The unprecedentedly large spin Hall resistance of up to 2.9 mOmega is attributed to the large spin Hall angle in Au through the skew scattering mechanism and the highly efficient spin injection due to the well-matched spin resistances of the chosen materials.     

Natriuretic peptides in ectopic myocardial tissues originating from mouse embryonic stem cells

In a previous report we described the survival and contractile function of mouse embryonic stem cell-derived cardiomyocytes in the host retroperitoneum. To further understand the nature of embryonic stem cell-derived cardiomyocytes, the study assessed the synthesis of natriuretic peptides in ectopic myocardial tissues of embryonic stem cell origin. Cardiomyocytes formed in embryoid body outgrowths were transplanted into the retroperitoneum of adult nude mice, and the myocardial tissues that developed were characterized by RT-PCR and immunohistochemistry concerning atrial and brain natriuretic peptides (ANP, BNP). In the outgrowths of embryoid bodies in vitro, gene expression of ANP and BNP was detected by RT-PCR and granules positive for the peptides were identified in a few cardiomyocytes by light and electron microscopic immunocytochemistry. Seven days after transplantation the transplants exhibited multidifferentiated teratoma tissues. Developing chamber myocardial tissues positive for cardiac troponin I, cadherin, and connexin 43 were evident in the transplants, which contained ANP-positive cardiomyocytes. Transplants with beating bundles were observed 30 days after transplantation, in which gene expression of both natriuretic peptides was detected. Myocardial tissues with abundant ANP-immunoreactivity, as well as with BNP-immunoreactivity to a lesser extent, were evident in the transplants. Also, myocardial tissues without immunoreactivity for natriuretic peptides were observed. Immunoelectron microscopy showed discernible secretory granules containing ANP and/or BNP in the cardiomyocytes. These results showed that part of the cardiomyocytes in embryonic stem cell-derived ectopic myocardial tissues are capable of producing natriuretic peptides, which suggests that they may be used as an endocrine source for cardiac hormones.     

Oscillation waveforms of SnO2-based thick-film co sensors

An oscillation phenomenon in SnO₂-based sensors, incorporating hydrophobic silica, has been noticeable when they are exposed to CO gas in air. Its waveform is a stable saw-tooth for sensors with 2 wt.% silica. Sensors with more than 5 wt.% silica, however, exhibit an oscillation with a complex wave when they are heated at higher temperature than 200°C and exposed to an appropriate high CO gas concentration. The dependences of critical conditions to be complex upon the sensor temperature, the gas concentration, and the silica contents have been examined. Also, the mechanisms of the appearance of the complex wave are discussed.