基于磁场传感器的层状磁电复合材料动态特性的有限元模型研究

依据Hamilton变分原理,运用有限元方法建立了用于磁场传感器的核心元件—磁电复合材料动态特性的有限元模型。应用所建立的模型求解了LT型Terfenol-D/PZT/Terfenol-D三层磁电复合材料的输出特性,并与实验结果进行对比分析。结果发现当静态偏置磁场为22.1 kA/m,正弦交流驱动磁场为7.4 kA/m、频率100 Hz时,计算结果和实验结果误差为0.9%。表明该模型适用于磁电复合材料输出特性为线性变化的区域。     

平移式浮动夹头的结构设计及应用

介绍了在加工换热器管板时采用的平移式浮动夹头的结构设计及应用情况。     

Hot Corrosion Behaviors of Ni-14%Cr Alloys in Molten Sulfate

The corrosion behaviors and mechanism of Ni-14%Cr alloys in molten salt with Na2SO4 at 1000℃ was investigated by means of XRD analysis and SEM observation. Results show that the alloys were subjected to the accelerated corrosion in molten salt and the corrosion kinetic of the alloy obeys the parabolic law. On the other hand, the corrosion-resistance of the alloy could be improved significantly by increasing of chromium content. Corrosion products may be divided into three layers, i. e. NiCr2O4, CoCr2O4, CoN...     

浅谈中文图书编目的几个问题

从文献编目所含有的环节及编目理论的作用入手,着重论述了文献编目中题名的选取、主题词的著录和图书在版编目对书目数据的影响。     

泸型成品酒货架期间质量变化及对策探讨

通过对泸型不同档次的成品酒在货架期间的酒体进行理化、色谱分析以及感官鉴评跟踪比较,初步得出:随货架时间的增加,总酸呈增加趋势,总酯呈降低趋势,尤以低度、低档次的成品酒更加突出;感官鉴评也表现出,随货架时间的增加,酒体后味现短淡,尤以低度、低档次的成品酒更显著。在此基础上,提出了在酒体设计中应采取的质量对策措施。     

嗜碱性芽孢杆菌碱性纤维素酶酶系的研究

本文研究了各种碳、氮源、ｐＨ、通风量等工艺条件对嗜碱性芽孢杆菌Ｖ－５产酶酶系的影响，通过酶在表面活性剂中的实验，分析不同表面活性剂对酶系中各组分的影响，初步研究酶系与去污力的关系，认为除以内切酶为主外，酶系中另二个组分，在去污效果中的辅助作用不容忽视。     

Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells

TRPV4 (transient receptor potential vanilloid 4), a calcium permeable TRP ion channel, is known to play a key role in endocytosis. However, whether it contributes to exocytosis remains unclear. Here, we report that activation of TRPV4 induced massive exocytosis in both melanoma A375 cell and heterologous expression systems. We show here that, upon application of TRPV4-specific agonists, prominent vesicle priming from endoplasmic reticulum (ER) was observed, followed by morphological changes of mitochondrial crista may lead to cell ferroptosis. We further identified interactions between TRPV4 and folding/vesicle trafficking proteins, which were triggered by calcium entry through activated TRPV4. This interplay, in turn, enhanced TRPV4-mediated activation of folding and vesicle trafficking proteins to promote exocytosis. Our study revealed a signaling mechanism underlying stimulus-triggered exocytosis in melanoma and highlighted the role of cellular sensor TRPV4 ion channel in mediating ferroptosis.     

Bioinformatics of Differentially Expressed Genes in Phorbol 12-Myristate 13-Acetate-Induced Megakaryocytic Differentiation of K562 Cells by Microarray Analysis

Megakaryocytes are large hematopoietic cells present in the bone marrow cavity, comprising less than 0.1% of all bone marrow cells. Despite their small number, megakaryocytes play important roles in blood coagulation, inflammatory responses, and platelet production. However, little is known about changes in gene expression during megakaryocyte maturation. Here we identified the genes whose expression was changed during K562 leukemia cell differentiation into megakaryocytes using an Affymetrix GeneChip microarray to determine the multifunctionality of megakaryocytes. K562 cells were differentiated into mature megakaryocytes by treatment for 7 days with phorbol 12-myristate 13-acetate, and a microarray was performed using RNA obtained from both types of cells. The expression of 44,629 genes was compared between K562 cells and mature megakaryocytes, and 954 differentially expressed genes (DEGs) were selected based on a p-value < 0.05 and a fold change >2. The DEGs was further functionally classified using five major megakaryocyte function-associated clusters—inflammatory response, angiogenesis, cell migration, extracellular matrix, and secretion. Furthermore, interaction analysis based on the STRING database was used to generate interactions between the proteins translated from the DEGs. This study provides information on the bioinformatics of the DEGs in mature megakaryocytes after K562 cell differentiation.     

一种基于跟踪微分器的智能车辆加速度闭环控制方法

为了满足智能车辆进行L3及以上级别智能驾驶的需求,文章开发了一种基于跟踪微分器的加速度闭环控制方法.该方法采用跟踪微分器对加速度进行辨识,并对加速度进行闭环控制.其上层控制器根据车辆的当前速度、目标速度以及加速或者减速的距离计算一个加速度指令,并通过CAN网络将该指令发送到加速度闭环控制器中,从而实现对智能车辆进行加速...