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排序方式: 共有2430条查询结果,搜索用时 31 毫秒
11.
Masaaki Miyamoto Hiroyuki Koike Toshio Sada Yasuteru Ijima Junichiro Fukushige Norio Nakamura 《Lipids》1991,26(12):1316-1319
Platelet-activating factor (PAF) is a potent inflammatory mediator which is released by various inflammatory cells and produced
by certain tissues, including the kidney. PAF has been shown to increase glomerular permeability to protein and to decrease
glomerular filtration rate (GFR) by contracting mesangium. On the basis of these observations, it has been suspected that
PAF may play a role as mediator of glomerular damage in glomerular nephritis. To examine this possibility, we studied the
effects of a specific PAF antagonist, R-75,317, on the development of an experimental model of anti-glomerular basement membrane
(anti-GBM) glomerulonephritis. Glomerulonephritis was initiated by injecting rabbit anti-rat GBM serum into rats. Proteinuria
gradually developed after serum injection, plateaued at week 2, and remained at the high level of week 2 throughout the experimental
period (6 wk). Chronic treatment with R-75,317 (10 mg/kg/day i.p.) tended to delay the onset of proteinuria and significantly
accelerated the recovery phase. Creatinine clearance (Ccr) fell to 40% at week 3. R-75,317 treatment completely prevented
this decline of Ccr. Histological changes in this model (glomerular hypertrophy, proliferation of mesangial matrix and interstitial
fibrosis) were also ameliorated by the R-75,317 treatment. The results suggest that PAF may play a role in the development
of glomerulonephritis and that PAF antagonists could be used in the treatment of human renal disease.
Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl
Ether Lipids, May 1989. 相似文献
12.
13.
SiB4±x
and SiB6 plates were prepared by chemical vapour deposition (CVD) using SiCl4, B2H6 and H2 gases under the conditions of deposition temperatures (T
dep) from 1323–1773 K, total gas pressures (P
tot) from 4–40 kPa and B/Si source gas ratio (m
B/Si=2B2H6/SiCl4) from 0.2–2.8. The effects of CVD conditions on the morphology, structure and composition of the deposits were examined.
High-purity and high-density SiB4±x
and SiB6 plates about 1 mm thick were obtained at the deposition rates of 71 and 47 nm s−1, respectively. The lattice parameter, composition and density of CVD SiB4±x
plates were dependent on their non-stoichiometry. The lattice parameter,a, was 0.6325 nm, butc ranged from 1.262–1.271 nm.The B/Si atomic ratio ranged from 3.1–5.0, and the density ranged from 2.39–2.45×103 kg m−3. The CVD SiB6 plates showed constant values of lattice parameters (a=1.444 nm,b=1.828 nm,c=0.9915 nm), composition (B/Si=6.0) and density (2.42×103 kg m−3), independent of CVD conditions. 相似文献
14.
High performance liquid chromatographic separation of a series of mono-, di- and trihydroxylated 5β-cholanic acids which differ
only in position and configuration of hydroxyl groups at positions C-3, C-7 and/or C-12, is reported. The C-24 free acids
were derivatized to four different classes of UV-sensitive esters, i.e.,p-bromophenacyl (BP),m-methoxyphenacyl (MP), 4-nitrophthalimidemethyl (NPM) and 9-anthrylmethyl (AM) esters, and chromatographed on two, variants
of C18 reversed-phase columns (Nova-Pak C18 and Zorbax ODS) with methanol-water systems as mobile phase. Separation efficiency and elution order of some isomeric pairs
were influenced by both the structure of the C-24 ester groups and the nature of the columns used. Excellent chromatographic
properties were found for those derivatives, particularly for the NPM esters. 相似文献
15.
The esters of dichloropropanols from the byproduct of hydrolysates during food processing were degraded by the cell-free extracts of a dichloropropanol-assimilating bacterium of Pseudomonas sp. OS-K-29. 1-Acyloxy-2,3-dichloropropane was hydrolysed into the corresponding carbonic acid and 2,3-dichloropropanol, and then the dichloropropanol was dechlorinated. The esterase activity of the cell-free extracts was effective for the esters of the dichloropropanols and monoacylglycerides, but not for hydrolysing the lipase substrates such as triacylglycerides and Tween 60. A comparative study using a series of octanoyl glycerides and the esters of the dichlopropanols showed that the substrate specificities of the cell-free extracts were similar to the monoacylglyceride lipase from Penicillium camembertii. 相似文献
16.
A new evacuation method for emergencies, the Follow Me method, in which each leader takes only one evacuee to an exit without gesturing or loudly directing many evacuees toward the exit, was compared, in two field experiments, with a traditional method, the Follow Directions method, in which each leader indicates the direction with a loud voice and vigorous gestures. Results showed that the Follow Me method was more effective when the leader-to-evacuee ratio was relatively small, such as 1:4, and less effective when the ratio was large, such as 1:8. Effective evacuation by the Follow Me method was shown to be caused by the drawing power of emergent small groups. Generating from around a leader, other evacuees rapidly formed a collective stream toward the exit. Small groups can be used as a lever in moving a larger collectivity in an emergency, as well as in activating a large formal organization. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
17.
Heat Generation in Multilayer Piezoelectric Actuators 总被引:1,自引:0,他引:1
Jiehui Zheng Sadayuki Takahashi Shoko Yoshikawa Kenji Uchino J. W. C. de Vries 《Journal of the American Ceramic Society》1996,79(12):3193-3198
Multilayer piezoelectric actuators when driven under high frequency, generate significant heat, which influences the reliability and other piezoelectric properties. In this paper, heat generation in various types of multilayer PZT-based actuators was studied. Experimental results showed that heat generation is mainly caused by ferroelectric hysteresis loss in the stress-free state. A simplified analytic method was established to evaluate the temperature rise, which is useful for the design of multilayer and other high-power actuators. 相似文献
18.
The fatigue crack propagation rate and the fatigue threshold were investigated for transverse-butt-welded joints of the austenitic stainless steel SUS304. Specimens were of the center-cracked type. In three sets of tests the fatigue crack passed through the weld metal, and in the other two sets, through the base metal. The fatigue crack propagation properties coincided with each other at different stress ratios for the weld metal, and at the higher stress ratios for the base metal. The propagation properties improved at the stress ratio of zero for the base metal. The absence of a stress ratio effect means that the coincided properties are basic ones in which fatigue crack closure does not occur. However, fractographic appearance and surface roughness were quite different between weld metal and base metal. The coincidence of fatigue crack propagation properties in spite of the difference in fractographic features reveals that the fractographic appearance and surface roughness only have a minor effect on basic fatigue crack propagation behaviour. 相似文献
19.
Transaction Oriented Prolog-Online Environment is a multi-user, mainframe implementation of the logic programming language Prolog, specially designed and developed for the data processing environment. This article describes the background, functionality, implementation and use of TOP-ONE, stressing that applications of knowledge-based systems technology to data processing environments will achieve full success only when existing systems and existing conventional data are incorporated within the applications. 相似文献
20.
Polarization-controlled single-mode VCSEL 总被引:2,自引:0,他引:2
Yoshikawa T. Kawakami T. Saito H. Kosaka H. Kajita M. Kurihara K. Sugimoto Y. Kasahara K. 《Quantum Electronics, IEEE Journal of》1998,34(6):1009-1015
Relative intensity noise (RIN) in a vertical-cavity surface-emitting laser (VCSEL) was greatly reduced through the use of polarization control to eliminate competition between two orthogonal polarization states by ensuring there was only one polarization state. Polarization was stable with optical feedback of up to 10%. Polarization control was achieved by inducing a small loss anisotropy in fundamental transversal mode VCSEL's. Anisotropic post structures, such as a rectangular post, an oblique post, or a zigzag-sidewall post, were found to be effective in creating loss anisotropy without serious degradation of other VCSEL characteristics such as light-output power or beam profile 相似文献