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131.
Trans‐fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll‐like receptors
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Kensuke Kondo Tatsuro Ishida Tomoyuki Yasuda Hideto Nakajima Kenta Mori Nobuaki Tanaka Takeshige Mori Tomoko Monguchi Masakazu Shinohara Yasuhiro Irino Ryuji Toh Yoshiyuki Rikitake Kazunobu Kiyomizu Yoshiaki Tomiyama Junichiro Yamamoto Ken‐ichi Hirata 《Molecular nutrition & food research》2015,59(4):729-740
132.
Cristina Di Carluccio Enrique Crisman Prof. Yoshiyuki Manabe Rosa Ester Forgione Dr. Alessandra Lacetera Dr. Jussara Amato Dr. Bruno Pagano Prof. Antonio Randazzo Prof. Angela Zampella Prof. Rosa Lanzetta Prof. Koichi Fukase Prof. Antonio Molinaro Prof. Paul R. Crocker Prof. Sonsoles Martín-Santamaría Dr. Roberta Marchetti Prof. Alba Silipo 《Chembiochem : a European journal of chemical biology》2020,21(1-2):129-140
CD22 (Siglec-2) is a B-cell surface inhibitory protein capable of selectively recognising sialylated glycans, thus dampening autoimmune responses against self-antigens. Here we have characterised the dynamic recognition of complex-type N-glycans by human CD22 by means of orthogonal approaches including NMR spectroscopy, computational methods and biophysical assays. We provide new molecular insights into the binding mode of sialoglycans in complex with h-CD22, highlighting the role of the sialic acid galactose moieties in the recognition process, elucidating the conformational behaviour of complex-type N-glycans bound to Siglec-2 and dissecting the formation of CD22 homo-oligomers on the B-cell surface. Our results could enable the development of additional therapeutics capable of modulating the activity of h-CD22 in autoimmune diseases and malignancies derived from B-cells. 相似文献
133.
134.
Yoshiyuki Watanabe Toru Yahagi Yutaka Abe Hiroki Murayama 《Electrical Engineering in Japan》2019,206(2):54-60
We have fabricated a silicon MEMS resonator aiming at multimodal sensors, and evaluated vibration characteristics by electromagnetic drive and induced electromotive force detection. The resonance frequency of the driving voltage of 0.6 Vpp shows torsional vibration of approximately 87 kHz, and the resonance frequency is shifted toward the low‐frequency side as the driving voltage increases. Resonance characteristics due to temperature change and film stress were evaluated. 相似文献
135.
Jituo Li Guodong Lu Dongliang Zhang Yoshiyuki Sakaguti 《The International Journal of Advanced Manufacturing Technology》2006,30(11-12):1093-1100
Surface trimming is widely used in surface modeling, texture mapping and medical simulation. In existing methods of surface trimming, cutting lines are usually picked manually or assumed to be known or determined by computing the intersection between two surfaces. This paper presents a new method of region search for trimming triangulated surfaces. In the method, the boundary of a region is first searched and then the geometric elements of a mesh is labeled with internal or external marks; finally, a 3D patch is obtained by re-triangulating the internal region. The proposed algorithm is suitable for interactive operations of surface trimming. Experimental results show that the algorithm is robust and efficient. 相似文献
136.
To clarify the effect of hydrogen gas on fretting fatigue strength of the materials, which supposed to be used for hydrogen utilization machines, fretting fatigue tests were conducted in hydrogen gas. It is important to take fretting fatigue into account in strength design, because many fatigue failure accidents have occurred at joints or contact parts between components. As a part of the experiments, an austenitic stainless steel was focused in this paper. The material was SUS 304. Fretting fatigue strength in hydrogen gas decreased compared with that in air. Tangential force coefficient increased in the reverse order of fretting fatigue strength. Therefore, one of the reasons of the decrease of fretting fatigue strength was that tangential force was different depending on the environment. Absorption of hydrogen occurred during fretting in hydrogen gas was detected. The absorption could be considered as one of the causes of the decrease of fretting fatigue strength, since fretting fatigue life of pre-charged specimen was decreased and also the crack propagation threshold of short fatigue crack was reduced by hydrogen charge. 相似文献
137.
High‐Performance Dibenzoheteraborin‐Based Thermally Activated Delayed Fluorescence Emitters: Molecular Architectonics for Concurrently Achieving Narrowband Emission and Efficient Triplet–Singlet Spin Conversion
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Thermally activated delayed fluorescence (TADF) materials, which enable the full harvesting of singlet and triplet excited states for light emission, are expected as the third‐generation emitters for organic light‐emitting diodes (OLEDs), superseding the conventional fluorescence and phosphorescence materials. High photoluminescence quantum yield (ΦPL), narrow‐band emission (or high color purity), and short delayed fluorescence lifetime are all strongly desired for practical applications. However, to date, no rational design strategy of TADF emitters is established to fulfill these requirements. Here, an epoch‐making design strategy is proposed for producing high‐performance TADF emitters that concurrently exhibiting high ΦPL values close to 100%, narrow emission bandwidths, and short emission lifetimes of ≈1 µs, with a fast reverse intersystem crossing rate of over 106 s?1. A new family of TADF emitters based on dibenzoheteraborins is introduced, which enable both doped and non‐doped TADF‐OLEDs to achieve markedly high external electroluminescence quantum efficiencies, exceeding 20%, and negligible efficiency roll‐offs at a practical high luminance. Systematic photophysical and theoretical investigations and device evaluations for these dibenzoheteraborin‐based TADF emitters are reported here. 相似文献
138.
Muhammad Iqbal Yusuf Valentino Kaneti Jeonghun Kim Brian Yuliarto Yong‐Mook Kang Yoshio Bando Yoshiyuki Sugahara Yusuke Yamauchi 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(6)
Palladium (Pd) plays an important role in numerous catalytic reactions, such as methanol and ethanol oxidation, oxygen reduction, hydrogenation, coupling reactions, and carbon monoxide oxidation. Creating Pd‐based nanoarchitectures with increased active surface sites, higher density of low‐coordinated atoms, and maximized surface coverage for the reactants is important. To address the limitations of pure Pd, various Pd‐based nanoarchitectures, including alloys, intermetallics, and supported Pd nanomaterials, have been fabricated by combining Pd with other elements with similar or higher catalytic activity for many catalytic reactions. Herein, recent advances in the preparation of Pd‐based nanoarchitectures through solution‐phase chemical reduction and electrochemical deposition methods are summarized. Finally, the trend and future outlook in the development of Pd nanocatalysts toward practical catalytic applications are discussed. 相似文献
139.
Nicola Manca Luca Pellegrino Teruo Kanki Warner J. Venstra Giordano Mattoni Yoshiyuki Higuchi Hidekazu Tanaka Andrea D. Caviglia Daniele Marré 《Advanced materials (Deerfield Beach, Fla.)》2017,29(35)
Relaxation oscillators consist of periodic variations of a physical quantity triggered by a static excitation. They are a typical consequence of nonlinear dynamics and can be observed in a variety of systems. VO2 is a correlated oxide with a solid‐state phase transition above room temperature, where both electrical resistance and lattice parameters undergo a drastic change in a narrow temperature range. This strong nonlinear response allows to realize spontaneous electrical oscillations in the megahertz range under a DC voltage bias. These electrical oscillations are employed to set into mechanical resonance a microstructure without the need of any active electronics, with small power consumption and with the possibility to selectively excite specific flexural modes by tuning the value of the DC electrical bias in a range of few hundreds of millivolts. This actuation method is robust and flexible and can be implemented in a variety of autonomous DC‐powered devices. 相似文献
140.
In this paper, we evaluate a novel flaw-detection technique for metallic surfaces based on the use of phase-type blazed gratings. Transparent blazed gratings were prepared by the soft nanoimprint method involving the transfer of a template (a reflective grating structure used for spectroscopy) onto silicone rubber. The blazed gratings were then integrated into an imaging system to observe the reflective metal sample. Due to the low-pass-filtering properties of the gratings, the captured image was notably blurred. This characteristic aids in flaw detection on metallic surfaces because the captured image is adequate to distinguish flaws in the targeted area on the basis of the texture of the rough surface, including any other structures that were unintended. The use of double-sided gratings with crossing grating vectors was found to be efficient for homogenous low-pass filtering. Such flaw-detection techniques are expected to be useful for conducting quality inspections of rolled steel plates since the surface contains both a rough surface and undesirable flaws. 相似文献