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41.
SrO and CaO, related compounds of BSCCO superconductor, are grown onto SrTiO3(100) substrates with molecular beam epitaxy(MBE) technique. During growth, the specular spots of RHEED patterns show intensity oscillations, indicating two dimensional growth. The periods of oscillations are utilized to calculate the atom fluxes. It is shown that sublimation processes of both Sr and Ca metals in the effusion cells are stable under the growth condition of oxide films. The periods of oscillations during the SrO growth are independent of substrate temperature, confirming that Sr atoms are oxidized immediately and stay on the substrate surface without re-evaporation. These informations are practically available for precise control of the atomic layer controlled MBE of BSCCO superconductor thin films.On leave from Superconductiivity Research Laboratory, ISTEC. 相似文献
42.
Sota H Yoshimine H Whittier RF Gotoh M Shinohara Y Hasegawa Y Okahata Y 《Analytical chemistry》2002,74(15):3592-3598
Despite high theoretical sensitivity, low-cost manufacture, and compactness potentially amenable to lab-on-a-chip use, practical hurdles have stymied the application of the quartz crystal microbalance (QCM) for aqueous applications such as detection of biomolecular interactions. The chief difficulty lies in achieving a sufficiently stable resonance signal in the presence of even minute fluctuations in hydrostatic pressure. In this work, we present a novel versatile planar sensor chip design (QCM chip) for a microliter-scale on-line biosensor. By sealing the quartz resonator along its edges to a flat, solid support, we provide uniform support for the crystal face not exposed to solvent, greatly decreasing deformation of the crystal resonator under hydrostatic pressure. Furthermore, this cassette design obviates the need for direct handling when exchanging the delicate quartz crystal in the flow cell. A prototype 27-MHz sensor signal exhibited very low noise over a range of flow rates up to 100 microL/min. In contrast, signals obtained from a conventional QCM sensor employing an O-ring-based holder were less stable and deteriorated even further with increasing flow rate. Additional control designs with intermediate amounts of unsupported undersurface yielded intermediate levels of stability, consistent with the interpretation that deformation of the crystal resonator under fluctuating hydraulic pressure is the chief source of noise. As a practical demonstration of the design's high effective sensitivity, we readily detected interaction between myoglobin and surface-bound antibody. 相似文献
43.
Atsushi Kanamori Fumio Tanaka Masaki Ominami Yuji Nadatani Shusei Fukunaga Koji Otani Shuhei Hosomi Noriko Kamata Yasuaki Nagami Koichi Taira Yasuhiro Fujiwara 《International journal of molecular sciences》2022,23(15)
The effects of psychological stress on eosinophilic gastrointestinal disorders have not been elucidated. This study investigated the effects of psychological stress in a mouse model of eosinophilic enteritis (EoN). BALB/c mice were treated with ovalbumin (OVA) to create an EoN model and subjected to either water avoidance stress (WAS) or sham stress (SS). Microscopic inflammation, eosinophil and mast cell counts, mRNA expression, and protein levels of type 2 helper T cell (Th2) cytokines in the ileum were compared between groups. We evaluated ex vivo intestinal permeability using an Ussing chamber. A corticotropin-releasing hormone type 1 receptor (CRH-R1) antagonist was administered before WAS, and its effects were analyzed. WAS significantly increased diarrhea occurrence and, eosinophil and mast cell counts, and decreased the villus/crypt ratio compared to those in the SS group. The mRNA expression of CRH, interleukin IL-4, IL-5, IL-13, eotaxin-1, and mast cell tryptase β2 significantly increased, and the protein levels of IL-5, IL-13, and OVA-specific immunoglobulin E (IgE) also significantly increased in the WAS group. Moreover, WAS significantly increased the intestinal permeability. The CRH-R1 antagonist significantly inhibited all changes induced by WAS. Psychological stress exacerbated ileal inflammation via the CRH-mast cell axis in an EoN mouse model. 相似文献
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45.
术语抽取从非结构化文本中自动抽取专业术语。该工作在中文分词、信息抽取、知识库构建中发挥着重要的作用。当前术语抽取方法很大程度上依赖于词的统计信息,由于基础教育学科中术语具有极强的长尾特性,导致基于统计的术语抽取方法很难抽取出处于尾端的术语。该文结合基础教育的学科特点,提出了DRTE: 一种利用术语定义与术语关系挖掘,综合构词规则与边界检测的术语抽取方法。该文以初高中的数学课本为数据源进行术语抽取,实验结果表明我们的术语抽取方法F1值达到82.7%,相比目前的方法提高了40.8%,能够有效地在中文基础教育领域进行自动化的术语抽取。 相似文献
46.
Seiichiro Katagiri SungGi Chi Yosuke Minami Kentaro Fukushima Hirohiko Shibayama Naoko Hosono Takahiro Yamauchi Takanobu Morishita Takeshi Kondo Masamitsu Yanada Kazuhito Yamamoto Junya Kuroda Kensuke Usuki Daigo Akahane Akihiko Gotoh 《International journal of molecular sciences》2022,23(9)
KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such as gastrointestinal stromal tumors and mast cell disease, molecular therapies targeting KIT mutations are being developed. In acute myeloid leukemia (AML), genome profiling via next-generation sequencing has shown that several genes that are mutated in patients with AML impact patients’ prognosis. Moreover, it was suggested that precision-medicine-based treatment using genomic data will improve treatment outcomes for AML patients. This paper presents (1) previous studies regarding the role of KIT mutations in AML, (2) the data in AML with KIT mutations from the HM-SCREEN-Japan-01 study, a genome profiling study for patients newly diagnosed with AML who are unsuitable for the standard first-line treatment (unfit) or have relapsed/refractory AML, and (3) new therapies targeting KIT mutations, such as tyrosine kinase inhibitors and heat shock protein 90 inhibitors. In this era when genome profiling via next-generation sequencing is becoming more common, KIT mutations are attractive novel molecular targets in AML. 相似文献
47.
48.
Takayoshi Yokoya Rikiya Yoshida Yuki Utsumi Koji Tsubota Hiroyuki Okazaki Takanori Wakita Yoshikazu Mizuguchi Yoshihiko Takano Takayuki Muro Yukako Kato Hiroshi Kumigashira Masaharu Oshima Hisatomo Harima Yoshihiro Aiura Hitoshi Sato Akihiro Ino Hirofumi Namatame Masaki Taniguchi Masaaki Hirai Yuji Muraoka 《Science and Technology of Advanced Materials》2012,13(5)
We have characterized the electronic structure of FeSe1−xTex for various x values using soft x-ray photoemission spectroscopy (SXPES), high-resolution photoemission spectroscopy (HRPES) and inverse photoemission spectroscopy (IPES). The SXPES valence band spectral shape shows that the 2 eV feature in FeSe, which was ascribed to the lower Hubbard band in previous theoretical studies, becomes less prominent with increasing x. HRPES exhibits systematic x dependence of the structure near the Fermi level (EF): its splitting near EF and filling of the pseudogap in FeSe. IPES shows two features, near EF and approximately 6 eV above EF; the former may be related to the Fe 3d states hybridized with chalcogenide p states, while the latter may consist of plane-wave-like and Se d components. In the incident electron energy dependence of IPES, the density of states near EF for FeSe and FeTe has the Fano lineshape characteristic of resonant behavior. These compounds exhibit different resonance profiles, which may reflect the differences in their electronic structures. By combining the PES and IPES data the on-site Coulomb energy was estimated at 3.5 eV for FeSe. 相似文献
49.
Voltage Control of Static Var Compensator for a Remote System Interconnected by Long‐Distance AC Cables 下载免费PDF全文
Yuji Tamura Shinji Takasaki Yasuyuki Miyazaki Hideo Takeda Shoichi Irokawa Kikuo Takagi Naoto Nagaoka 《Electrical Engineering in Japan》2014,186(3):19-30
The voltage variation in a remote system is large when the system is connected by long‐distance AC cables due to the cable capacitance. In Japan, the longest 54‐km 66‐kV AC submarine cable interconnection between the Kyushu mainland and Goto Islands was commissioned in 2005. It was requested to mitigate the voltage variation caused by switching off and on one circuit of the two circuits in the AC cables when a fault occurs. Since the conventional voltage control methods such as transformer tap changer or shunt capacitor and reactor banks are not sufficient because of their slow response time, a static var compensator (SVC) was installed on the Goto Islands. In such an application, an SVC control method should be developed so as not to override the existing voltage control systems. This paper describes the SVC control method developed for the Goto Islands AC interconnection project, which can be applied to similar situations. The effectiveness of the control method was verified by the results of effective value simulation and of field testing, which was implemented before the SVC was commissioned in 2007. © 2013 Wiley Periodicals, Inc. Electr Eng Jpn, 186(3): 19–30, 2014; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.22337 相似文献
50.
Invert traps have been successfully used to collect sediments at convenient locations within the sewer network, where large volumes of solids can be stored. In the present study, experiments have been performed in 15 cm wide and 5 m long channel for the measurement of retention ratios of five different invert trap configurations (namely, rectangular, trapezoidal with one side vertical, trapezoidal, trapezoidal with rectangular base, rectangular with trapezoidal base) having top width of 32 cm and depth of 28 cm with slots of three different sizes (namely, 5, 9 and 15 cm) for the flow of seven different sediment types (namely, two types of sand, glass beads and four types of plastic beads) at different flow rates for each trap. The flow rates selected in present study cover entire range of flow rate expected in channels during dry weather flow and monsoon. Flow field and retention ratio predictions for each invert trap configuration have been carried out using CFD modeling with the help of FLUENT software using Renormalization Group (RNG) k–ε along with Discrete Phase Model (DPM). The simulation results are capable of showing particle trajectories, the effect of flow rate and trap geometry on the flow patterns, developed within the trap. Based on CFD modeling and experimental measurements, it is concluded that the invert trap having rectangular shape with trapezoidal base is the most efficient trap configuration with highest sediment retention ratio. 相似文献