Porous nano-hydroxyapatite/collagen scaffold containing drug-loaded ADM–PLGA microspheres for bone cancer treatment

To develop adriamycin (ADM)-encapsulated poly(lactic-co-glycolic acid) (PLGA) nanoparticles in a porous nano-hydroxyapatite/collagen scaffold (ADM–PLGA–NHAC). To provide novel strategies for future treatment of osteosarcoma, the properties of the scaffold, including its in vitro extended-release properties, the inhibition effects of ADM–PLGA–NHAC on the osteosarcoma MG63 cells, and its bone repair capacity, were investigated in vivo and in vitro. The PLGA copolymer was utilized as a drug carrier to deliver ADM–PLGA nanoparticles (ADM–PLGA–NP). Porous nano-hydroxyapatite and collagen were used to materials to produce the porous nano-hydroxyapatite/collagen scaffold (NHAC), into which the ADM–PLGA–NP was loaded. The performance of the drug-carrying scaffold was assessed using multiple techniques, including scanning electron microscopy and in vitro extended release. The antineoplastic activities of scaffold extracts on the human osteosarcoma MG63 cell line were evaluated in vitro using the cell counting kit-8 (CCK8) method and live-dead cell staining. The bone repair ability of the scaffold was assessed based on the establishment of a femoral condyle defect model in rabbits. ADM–PLGA–NHAC and NHAC were implanted into the rat muscle bag for immune response experiments. A tumor-bearing nude mice model was created, and the TUNEL and HE staining results were observed under optical microscopy to evaluate the antineoplastic activity and toxic side effects of the scaffold. The composite scaffold demonstrated extraordinary extended-release properties, and its extracts also exhibited significant inhibition of the growth of osteosarcoma MG63 cells. In the bone repair experiment, no significant difference was observed between ADM–PLGA–NHAC and NHAC by itself. In the immune response experiments, ADM–PLGA–NHAC exhibited remarkable biocompatibility. The in vivo antitumor experiment revealed that the implantation of ADM–PLGA–NHAC in the tumor resulted in a improved antineoplastic effect and fewer adverse side effects than direct intraperitoneal injection of ADM. The ADM–PLGA–NHAC developed in this study exhibited excellent extended-release drug properties, bone repairing and antineoplastic efficacy, which make it a promising osteoconductivity material with the capability to inhibit osteosarcoma.     

La<Subscript>1−x</Subscript>Ag<Subscript>x</Subscript>FeO<Subscript>3</Subscript>/halloysites nanocomposite with enhanced visible light photocatalytic performance

La_1?xAg_xFeO₃/halloysites nanotubes (HNTs) nanocomposite was synthesized by sol–gel method. It was characterized by X-ray diffraction, transmission electron microscope, Fourier transform infrared spectroscopy and UV–visible diffused reflectance spectroscopy measurements. The photo-activity of the La_1?xAg_xFeO₃/HNTs nanocomposite was evaluated via degradation of methylene blue (MB) under visible-light irradiation. The results showed that the HNTs with unique pore structure favored the adsorption of organic molecules. Adequate Ag⁺ doping improved the absorption ability for visible light. The La_0.95Ag_0.05FeO₃/HNTs demonstrated the best photocatalytic performance, which achieved as high as 99 % for MB degradation exposed 2 h irradiation. However,further increasing of Ag⁺ doping gradually reduced the photocatalytic activity. The nanocomposite catalyst showed outstanding recyclability after eight cycles which still remained up to 90 %.     

气相法白炭黑填充天然橡胶的裂纹扩展机理

研究了不同粒径,不同份数的白炭黑对天然橡胶(NR)裂纹生长行为的影响。采用具有裂纹生长测试功能的DMA(DMA-Crack Growth)对预割口试样的裂纹扩展速度进行测试。利用超高速显微摄像技术对裂纹扩展尖端进行在线追踪,得到裂纹扩展尖端的动态显微图像。结果表明,添加20 phr原生粒径为15 nm的气相法白炭黑时,裂纹尖端韧带均匀且细密,对裂纹生长起到很好的阻碍作用;添加20 phr原生粒径为7 nm的气相法白炭黑时,对试样的裂纹生长有不利影响。     

纹饰在产品设计中的情感特征与功能

目的对产品造型中的纹饰符号特性、纹饰与产品商业价值的实现、纹饰与民族文化传播进行分析。方法以产品造型的纹饰构成元素特性为基础,通过纹饰符号情感特性的分析,对产品纹饰符号承载人文情感、传递特定文化价值及有效促使产品商业价值实现进行研究。结论通过纹饰与产品造型相互依存关系的理解、基于纹饰传统视觉文化创新发展途径的思考、基于纹饰的文化传播与产品商业价值实现的相互促进关系判别可知,产品造型中的优秀纹饰符号能在强化消费者情感认同的同时促进商业消费行为的达成,并且,在产品以消费形式被广泛传播的同时,依附于纹饰符号的文化现象也得到了有效传播。     

基于卡尔曼滤波的运动目标速度测量

移动机器人和智能无人驾驶车辆实时测量运动目标速度是实现自主导航的关键问题。提出了基于Kinect摄像机的机器视觉测速方法,利用图像处理技术检测运动目标,使用速度计算公式获取运动目标速度观测值。为提高速度测量精确度,减少环境噪声影响,应用卡尔曼滤波算法估计运动目标速度。试验结果表明,该方法在移动机器人作任意形式运动过程中可以实时方便地测量运动目标的直线速度以及角速度,具有高精确性、稳定性和广泛应用性。     

浅谈环氧沥青材料研究应用现状

由于环氧沥青材料的优异特性,对该材料的研究已成为各国研究人员的焦点。本文介绍了环氧沥青的应用背景、定义及其混合料性能;概述了国内外在环氧沥青材料研究领域的现状与进展;指出了该材料在应用发展中可能存在的问题并给出相应的建议。     

高精度表面粗糙度图像识别系统的研制

本文研究的是一套通过干涉显微镜成像,利用CCD相机提取干涉条纹进行图像识别和处理,实现高精度工件表面粗糙度快速、非接触、自动化的检测系统。该系统在干涉显微镜的结构基础上,安装了CCD相机,将干涉图像采集到计算机中,然后对采集到的图像进行滤波、判别、二值化处理、提取边缘轮廓,并按照GB/T 1031-2009《产品几何技术规范(GPS)表面结构轮廓法表面粗糙度参数及其数值》的要求进行计算,得到被测工件的表面粗糙度。经实验验证,该检测系统满足Ra值(0.01~0.1)μm和Rz值(0.1~1.0)μm测量要求,适用于高精度工件的表面粗糙度测量。     

60°镜面光泽测量值不确定度的评定

本文采用光泽度仪对漆膜的60°镜面光泽进行了测量,对产生测量不确定度的因素进行了分析,并对其A类和B类不确定度进行了分别评定,最终获得其测量结果的扩展不确定度。