Peroxisomes are involved in the swift increase in alcohol metabolism

The purpose of this study was to determine whether catalase-dependent alcohol metabolism is activated by alcohol (i.e., swift increase in alcohol metabolism). When ethanol or the selective substrate for catalase, methanol, was given (5.0 g/kg) in vivo 2 to 3 h before liver perfusion, methanol and oxygen metabolism were increased significantly. This increase was blocked when the specific Kupffer cell toxicant GdCl3 was administered 24 h before perfusion. These data support the hypothesis that catalase-dependent alcohol metabolism is activated by acute alcohol and that Kupffer cells are involved. Ethanol treatment in vivo increased ketogenesis from endogenous fatty acids nearly 3-fold and increased plasma triglycerides and hepatic acyl CoA synthetase activity; all increases were blocked by GdCl3. These findings support the hypothesis that ethanol increases H2O2 supply for catalase-dependent alcohol metabolism by increasing fatty acid supply. Infusion of oleate stimulated oxygen uptake 1.5-fold and methanol metabolism 4-fold, but these parameters were not altered by GdCl3. Moreover, the effects of ethanol treatment were blocked by the cyclooxygenase inhibitor indomethacin, and prostaglandin E2 (PGE2) was increased more than 200% in media from cultured Kupffer cells from rats treated with ethanol in vivo. Furthermore, lipoprotein lipase activity in retroperitoneal fat pads, which is known to be inhibited by PGE2, was reduced 70% by ethanol. These data are consistent with the hypothesis that Kupffer cells play a key role in activation of catalase-dependent alcohol metabolism, most likely by producing mediators (e.g., PGE2) that inhibit lipoprotein lipase, increase the supply of fatty acids to the liver, and increase generation of H2O2 via peroxisomal beta-oxidation.     

电沉积Co-Cr_3C_2纳米复合涂层的热稳定性（英文）

研究了电沉积Co-Cr3C2纳米复合涂层的热稳定性。析出相Cr3C2颗粒均匀弥散地分布在涂层中,质量分数大约为30%。600℃以上退火导致涂层当中形成孔隙。400℃以下和600℃以上退火分别有利于Co纳米晶粒沿[002]和[220]方向生长。低于400℃退火可以同时获得优异的耐磨性和高硬度。经低于400℃退火,涂层的摩擦系数达到0.12,而经200℃退火后的涂层的摩擦系数低至0.04。     

多医生单设备门诊排程优化

针对国内医院普遍存在预约机制不完善和医患矛盾突出引发的设备诊断依赖度高和病人等待时间长等问题,本研究特别考虑多医生同时诊断、设备检查以及病人设备检查后回诊等因素,建立普通门诊预约排程模型,在验证模型有效性的基础上,结合实际设计了六种排程规则并进行仿真研究,对提前预约与随机到达病人的比例、预约时间长度作了灵敏度分析,最后通过仿真实验找到相对较优的比例和预约时间值.     

液控单向阀的应用及故障与排除

介绍了液控单向阀的工作原理、类别及应用注意事项,对正确使用液控单向阀避免事故的发生进行了举例说明.同时,也列出了液控单向阀常出现的故障、产生原因及排除方法.对于掌握液控单向阀正确使用的方法、工作规律及维护知识,对改善液压系统,减少事故产生、提高维护液压系统的效率有重要意义.     

聚羟基丁酸酯改性研究进展

综述了近年来国内外生物降解材料聚羟基丁酸酯（PHB）改性研究的进展，主要包括PHB与羟基戊酸酯（HV）的共聚改性、PHB与顺丁烯二酸酐（MA）等的接枝改性，以及PHB与聚碳酸亚丙酯（PPC）、淀粉等的共混改性，并从力学性能、结晶情况、热稳定性和亲水性等方面考察了它们对PHB的影响。最后指出了PHB将来的研究方向。     

萘甲酰腙类阴离子受体的合成及识别研究

合成了用于识别阴离子的主体分子——2，4-二羟基苯乙酮缩-2-萘甲酰腙（X），通过红外光谱、核磁共振谱和质谱表征其结构；研究了阴离子对X吸收光谱的影响。实验表明：在乙腈中，阴离子加入对X的吸收光谱影响大小为：F^-〉H2PO4^-〉AcO^-，而cl^-、Br^-、I^-和HSO4^-对X的吸收光谱几乎没影响。Job法实验得出X与F的结合比为1：1。     

吉林油田双坨子地区气井固井技术

针对吉林油田双坨子地区上部地层低压易漏、气层多、分布井段长、气水层间互易造成固井漏失和层间互窜的技术难题,进行了气井固井对策分析。根据防气窜水泥浆体系应满足的条件,对防窜水泥浆外加剂进行了选择,筛选出了具有良好防窜性能的G302水泥浆体系,对防窜水泥浆体系性能进行了评价,形成了以采用G302防窜水泥浆为主,配合采用双凝水泥和"三压稳"为辅的综合防窜技术,提出了以JSS-1冲洗液配合NCH-2隔离液为主的适合低压易漏条件下提高顶替效率的技术措施。2005年在双坨子地区应用该技术进行了4口井现场施工,固井质量全部优质,解决了该地区多层系、长封固段条件下气井固井难题,形成了一套指导该地区气井固井的综合配套技术,并为解决类似的气井固井问题探索出了一条有效的技术途径。     

针对UART通信错误遗传性的止错码

UART协议简单易用,在串行通信设计中也得到了广泛的应用,但是由于它特有的通信协议,一旦出现错误,有可能导致后面大量正确的数据出错。针对UART在数据通信时的错误遗传性,找到了一组能够解决这种问题的止错码,详细分析了它的工作原理,为错误的及时终止提供了一定的理论基础。     

共轭凸轮的设计及基于AutoCAD的根切点修整

介绍了共轭凸轮及修整凸轮过切的一种方法,求出运动特性曲线来看修整后的效果.