About raising the sanitary culture of food industry's workers

The article includes: the basic problems of sanitary teaching of professional population groups, also the structure of training aids and examination tasks of sanitary knowledge for food industry's workers.     

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure. ROS not only function as intracellular signaling entities, but also induce damage to cellular molecules including DNA. Among the several dozen ROS-induced DNA base lesions generated in the genome, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant because of guanine’s lowest redox potential among DNA bases. In mammalian cells, 8-oxoG is repaired by the 8-oxoguanine DNA glycosylase-1 (OGG1)-initiated DNA base excision repair pathway (OGG1–BER). Accumulation of 8-oxoG in DNA has traditionally been associated with mutagenesis, as well as various human diseases and aging processes, while the free 8-oxoG base in body fluids is one of the best biomarkers of ongoing pathophysiological processes. In this review, we discuss the biological significance of the 8-oxoG base and particularly the role of OGG1–BER in the activation of small GTPases and changes in gene expression, including those that regulate pro-inflammatory chemokines/cytokines and cause inflammation.     

基于LDA模型和HowNet的多粒度子话题划分方法

针对LDA建模结果较泛化、子话题间文本相似度较高等问题,提出一种基于狄利克雷分配模型(LDA)和知网(HowNet)语义词典相结合的多粒度子话题划分方法(MGH-LDA).首先采用LDA模型对不同新闻源的新闻集合进行初划分,并根据文档贡献度获得相同新闻话题的文档集合;其次在TF-IDF模型基础上获取多粒度粗细特征,作为核心词特征集合来表征新闻文档,采用知网语义词典来计算新闻文档之间的相似度;最后通过single-pass增量聚类算法进行新闻文档的聚类,实现子话题划分.通过在真实新闻数据集上的实验,验证了该方法能有效地提高热点新闻话题子话题划分的准确率.     

准循环低密度校验码的快速编码

探讨了准循环低密度奇偶校验码的快速编码问题.基于循环矩阵的一种特性,提出了一种基于并行SRAA结构的编码算法.能够提高编码器的吞吐量.这种编码方法的主要优点是复杂度较低,且编码延时小.在FPGA上实现了码长为8 176而码率为0.875的有限几何LDPC码的编码器,吞吐量达到800 Mb/s.     

空间遥感用InGaAs短波红外探测器

简要比较了短波HgCdTe与InGaAs探测器的性能,介绍了PIN探测器的结构和主要性能指标,综述了InGaAs探测器的研究进展,特别是我国空间遥感用InGaAs的研究进展,并说明了研制空间遥感用InGaAs/InP光电探测器的意义.     

等壁厚螺杆钻具研制与现场试验

等壁厚螺杆钻具是近年来研制成功的一种新型螺杆钻具,具有单级密封压力高、转速低、扭矩大、曲率半径小、使用寿命长、耐高温和使用更加安全可靠等技术优势,适合在常规生产井、深井、斜井和定向井中使用,但国内刚处于试验研究阶段。在介绍等壁厚螺杆钻具国内外发展现状、基本结构与设计要点的基础上,指出了等壁厚螺杆的技术特点及与常规螺杆的主要区别,并在2个区块、相同井型进行了2种不同形式螺杆钻具的应用试验。现场数据分析表明,等壁厚螺杆钻具在不维修情况下,累计下井使用时间平均193 h,比常规螺杆提高40%以上,机械钻速提高22%。等壁厚螺杆钻具的使用寿命比常规螺杆钻具长,且能有效提高机械钻速、缩短建井周期,可以推广应用。      

膜盒式蒸汽疏水阀的特点及适用性分析

介绍了膜盒式蒸汽疏水阀的工作原理,推导得到了膜盒内介质的温度饱和蒸气压关系式,分析了阀片的受力平衡,指出了决定阀片动作的因素和膜盒式蒸汽疏水阀国产化进程中要解决的关键问题。     

基于RFPECVD方法不锈钢上沉积类金刚石薄膜的机械与摩擦特性

讨论用射频等离子体增强化学气相沉积(RFPECVD)工艺,在室温下实现在1Cr18Ni9Ti不锈钢基底上镀类金刚石(DLC)膜.为提高DLC膜的结合力,首先在不锈钢基底上沉积Ti/TiN/TiC功能梯度膜.借助所设计的界面过渡层,成功地在不锈钢基底上沉积了一定厚度的DLC膜.通过优化沉积参数,所沉积的DLC膜在与100Cr6钢球对磨时摩擦系数低于0.020.在摩擦过程中DLC膜的磨损机制借助SEM、Raman分析进行了研究.     

Smart magnetic poly(N-isopropylacrylamide) to control the release of bio-active molecules

Thermo switchable magnetic hydrogels undoubtedly have a great potential for medical applications since they can behave as smart carriers able to transport bioactive molecules to a chosen part of the body and release them on demand via magneto-thermal activation. We report on the ability to modify the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM) on demand from 32 °C to LCST ≥37 °C. This was achieved by the absorption of controlled amounts of magnetite nanoparticles on the polymer chains. We show, through the effect on cell viability, that the resulting magnetic PNIPAM is able to trap and to release bio-active molecules, such as cell growth factors. The activities of the released bio molecule are tested on human umbilical vein endothelial cells culture. We demonstrate that the LCST of the magnetic PNIPAM can be reached remotely via inductive heating with an alternating magnetic field. This approach on magnetic PNIPAM clearly supports appealing applications in safe biomedicine.     

Influence of diffusion time on property of steel—aluminum solid to liquid bonding

The bonding of solid steel to liquid aluminum was conducted using rapid solidification.The influence of diffusion time on interfacial shear strength was studied.The results show that when the temperature of aluminum liquid is 700℃and the preheat temperature of steel plate is 250℃,the relationship between diffusion time(t) and interfacial shear strength(σ)is σ=15.1 8.14t-0.37t 0.005t^3,and the maximum interfacial shear strength is 71.1MPa.