Modeling representative Gen‐IV molten fuel reactivity effects in the ZEPHYR ZPR ‐ LFR analysis

Studies related to severe core accidents constitute a crucial element in the safety design of Gen‐IV systems. A new experimental program, related to severe core accidents studies, is proposed for the zero‐power experimental physics reactor (ZEPHYR) future reactor. The innovative program aims at studying reactivity effects at high temperature during degradation of Gen‐IV cores by using critical facilities and surrogate models. The current study introduces the European lead‐cooled system (ELSY) as an additional Gen‐IV system into the representativity arsenal of the ZEPHYR, in addition to the sodium‐cooled fast reactors. Furthermore, this study constitutes yet another step towards the ultimate goal of studying severe core accidents on a full core scale. The representation of the various systems is enabled by optimizing the content of plutonium oxide in the ZEPHYR fuel assembly. The study focuses on representing reactivity variation from 900°C at nominal state to 3000°C at a degraded state in both ELSY and Advanced Sodium Technological Reactor for Industrial Demonstration (ASTRID) cores. The study utilizes the previously developed calculation scheme, which is based on the coupling of stochastic optimization process and Serpent 2 code for sensitivity analysis. Two covariance data are used: the ENDF 175 groups for ELSY and the Covariance Matrix Cadarache (COMAC) 33 groups for ASTRID. The effect of the energy group structure of the covariance data on the representativity process is found to be significant. The results for single degraded ELSY fuel assembly demonstrate high representativity factor (>0.95) for reactivity variation and for the criticality level. Also, it is shown that the finer energy group structure of the covariance matrices results in dramatic improvement in the representation level of reactivity variations.     

Tensile and water barrier properties of cassava starch composite films reinforced by synthetic zeolite and beidellite

Composites films were prepared by the casting method using native cassava starch plasticized with glycerol and 3D or 2D synthetic fillers i.e. Beta zeolite and Na-beidellite type 2:1 phyllosilicate. Special attention was paid to the effect of the filler contents and type on the mechanical and barrier properties. It was shown that films reinforced with lyophilized Beta zeolite presented both high water solubility (WS) and water vapor permeability (WVP) values than the pristine starch whereas an improvement on the WVP was found for composites prepared from Na-beidellite or from non lyophilized Beta zeolite. For the two types of fillers, a drastic increase of the mechanical properties (especially in the Young’s modulus) was observed.     

The effects of pharmaceuticals on the regeneration of the cnidarian, Hydra attenuata

The Hydra attenuata regeneration assay was used to identify the teratogenic potential of 10 pharmaceuticals identified in effluent from a large city wastewater treatment plant (WWTP). Three types of solvents were used to solubilise the pharmaceuticals (DMSO, acetone and ethanol), at concentrations determined to have no significant effect on measured endpoints. On the one hand, regeneration was significantly inhibited at (nominal) concentrations of 1, 5 and 1 mg/L for gemfibrozil, ibuprofen and naproxen respectively and at the higher concentration of 50 mg/L for bezafibrate and trimethoprim. On the other hand, carbamazepine and the antibiotics sulfapyridine, oxytetracycline and novobiocin significantly increased regeneration at 25, 5, 50 and 50 mg/L respectively. Relatively high IC50 values of 0.9, 3.84, 4.9 and 22.5 mg/L were calculated for gemfibrozil, ibuprofen, naproxen and bezafibrate, respectively. However when subjected to tier two toxicity assessment under EU regulatory guidance using environmentally relevant concentrations a MEC/PNEC value>1 was calculated for gemfibrozil, ibuprofen and naproxen indicating teratogenic potential and the necessity for further tier three assessment. A toxicity index (TI) was also calculated using three different techniques, with TI values>3 (indicating teratogenic potential) found for gemfibrozil, ibuprofen, naproxen and bezafibrate and >1 (indicating a weak teratogenic potential) found for carbamazepine. These results are discussed in the context of their environmental relevance and toxic potential.     

Lipochitin Oligosaccharides Immobilized through Oximes in Glycan Microarrays Bind LysM Proteins

Glycan microarrays have emerged as novel tools to study carbohydrate–protein interactions. Here we describe the preparation of a covalent microarray with lipochitin oligosaccharides and its use in studying proteins containing LysM domains. The glycan microarray was assembled from glycoconjugates that were synthesized by using recently developed bifunctional chemoselective aminooxy reagents without the need for transient carbohydrate protecting groups. We describe for the first time the preparation of a covalent microarray with lipochitin oligosaccharides and its use for studying proteins containing LysM domains. Lipochitin oligosaccharides (also referred to as Nod factors) were isolated from bacterial strains or chemoenzymatically synthesized. The glycan microarray also included peptidoglycan‐related compounds, as well as chitin oligosaccharides of different lengths. In total, 30 ligands were treated with the aminooxy linker molecule. The identity of the glycoconjugates was verified by mass spectrometry, and they were then immobilized on the array. The presence of the glycoconjugates on the array surface was confirmed by use of lectins and human sera (IgG binding). The functionality of our array was tested with a bacterial LysM domain‐containing protein, autolysin p60, which is known to act on the bacterial cell wall peptidoglycan. P60 showed specific binding to Nod factors and to chitin oligosaccharides. Increasing affinity was observed with increasing chitin oligomer length.     

An improved hybrid particle-element method for hypervelocity impact simulation

An improved hybrid particle-finite element method has been developed for hypervelocity impact simulation. The method combines the general contact-impact capabilities of particle codes with the true Lagrangian kinematics of large strain finite element formulations. Unlike some alternative schemes which couple Lagrangian finite element models with smooth particle hydrodynamics, the present formulation makes no use of slidelines or penalty forces.     

Coulomb Blockade Peak Statistics Influenced by Background Charge Configuration

Statistics of Coulomb blockade oscillations in metallic singleelectron transistors are investigated. We observe stronglynon-Gaussian distributions of nearest-neighbor conductancepeak spacings. The fluctuations of peak position are found tobe reproducible as a function of gate voltage, with ahysteresis when sweeping the voltage up and down. Our resultsare explained in terms of gate potential dependentbistabilities in the background charge configuration. Weemphasize the importance of carefully taking into account theenvironmental charge fluctuations in high sensitivityelectrometric SET experiments, like such on single particlelevel statistics in semiconductor quantum dots.     

Study of polyamines and their precursor amino acids in Grenache noir and Syrah grapes and wine of the Rhone Valley

Polyamines and their amino acid precursors were determined in Grenache and Syrah grapes and in wines made from these grapes. The compounds analysed were the polyamines putrescine, spermidine, and spermine, in addition to their precursors, ornithine, agmatine and arginine. The analytes were determined by reversed-phase high performance liquid chromatography (HPLC) with fluorescence detection using FMOC (fluorenylmethylchloroformate) as a pre-column derivatising agent Grape clusters were sampled from flowering to full maturity at different developmental stages. In addition, different berry parts were analysed separately from half veraison onwards. It appears that at berryset there is a decrease in the concentration of arginine, whereas polyamine concentrations remain constant at this stage. Concentrations of polyamines increased from must to alcoholic to malolactic fermentation; putrescine was the most abundant in wine (mean concentration after malolactic fermentation, MLF was 4.93 mg/l) followed by spermidine and then spermine (mean concentrations after MLF were 1.84 and 0.17 mg/l, respectively). In three of the four fermentation sites concentrations of all three compounds were greater in Syrah than in Grenache wines. In both varieties, it appears that polyamine biosynthesis occurs preferentially from arginine via agmatine. In all cases, concentrations of polyamines found in these grapes and wines were significantly below the levels typically found in other fermented foods.