新疆灌溉用水定额分区初步研究

在综合分析新疆各地区地形地貌、气候特征、水资源状况、种植结构、农业灌溉用水现状和经济发展水平等因素基础上,采用共区优选法对新疆灌溉用水定额进行分区,并提出相应的改善措施。该结果可为提高新疆灌溉用水率和用水效率,以及为灌溉管理节水提供决策参考。     

新型液压打桩锤的系统仿真研究

对一种新型液压打桩锤的打桩过程进行了运动学及动力学分析,并在此基础上提出了桩锤在各个打击过程的数学模型.最后对各阶段进行了仿真及分析,仿真研究对改进和优化打桩锤的各个设计参数具有指导意义.     

一种温压炸药抛洒密度的间接测量方法

温压炸药在爆炸过程中的抛洒密度决定其毁伤性能,而目前尚未找到一种合适的方法对抛洒密度进行直接测量进而对炸药的毁伤性能进行评估。针对该问题,提出一种通过测量温度分布间接反映炸药抛洒密度的方法。为满足爆炸场高温、高压、迅速等恶劣条件,依据声温理论所定义的声速与温度之间的关系,提出利用声层析成像重建来测量温度分布。通过建立模型和模拟仿真验证,分别利用联合迭代重建法和最小二乘法重建并进行结果对比,得到的相对误差分别为7.2%,5.1%,5.6%,4.2%,基本达到测试准确度要求,说明该方法在研究爆炸场温度分布反映炸药抛洒密度的问题上有一定的实用性和有效性。     

不同油酸加入量的纳米磁粉对磁性流体的性能影响

通过改变磁粉制备过程中的油酸加入量,来研究不同油酸加入量的磁粉对磁粉及磁性流体性能的影响。     

关于铸铁小件报价的系统总结

铸铁件在报价之前须根据铸造工艺、机械加工工艺、热处理工艺、表面处理工艺等作出全面系统的评估分析,以降低潜在的风险,然后结合本厂新产品开发能力,生产能力,质量控制能力,再进行合理的报价。     

基于UG的辅助刀架设计与数控加工

车床辅助刀架是根据其车床加工工艺的特殊需要而专门设计的工艺装备,针对制动轮的加工特点,应用UG软件进行了辅助刀架的设计,并对其进行数控加工。实践证明,该辅助刀架的设计简单实用,明显提高生产效率。     

An integrated bioinformatics analysis and experimental study identified key biomarkers CD300A or CXCL1, pathways and immune infiltration in diabetic nephropathy mice

Diabetic nephropathy (DN) is a common microvascular complication that easily leads to end-stage renal disease. It is important to explore the key biomarkers and molecular mechanisms relevant to diabetic nephropathy (DN). We used highthroughput RNA sequencing to obtain the genes related to DN glomerular tissues and healthy glomerular tissues of mice. Then we used LIMMA to analyze differentially expressed genes (DEGs) between DN and non-diabetic glomerular samples. And we performed KEGG, gene ontology functional (GO) enrichment, and gene set enrichment analysis to reveal the signaling pathway of the disease. The CIBERSORT algorithm based on support vector machine was used to determine the immune infiltration score. Random forest algorithm and Cytoscape obtained hub genes. Finally, we applied co-staining, immunohistochemical staining, RT-qPCR and western blotting to validate the protein and mRNA expression of both hub genes. We obtained 913 DEGs mainly related to inflammatory factors and immunity. GSEA results showed that differential genes were mainly enriched in IL-17 signaling pathway, lipid and atherosclerosis, rheumatoid arthritis, TNF signaling pathway, neutrophil extracellular trap formation, Staphylococcus aureus infection and other pathways. The intersection of the random forest algorithm and Cytoscape revealed both hub genes of CD300A and CXCL1. Experiments have shown that the both key genes of CD300A and CXCL1 shown increased expression in glomerular podocytes, and are related to the inflammation of diabetic nephropathy. And immunohistochemical staining and RT-qPCR further confirmed that the protein and mRNA expression level of CD300A or CXCL1 in glomeruli tissue in DN mice were increased. The expression levels of CD300A and CXCL1 increased significantly under HG (high glucose) stimulation, further confirming that diabetes can lead to increased levels of CD300A and CXCL1 at the cellular level. Through bioinformatics analysis, machine learning algorithms, and experimental research, CD300A and CXCL1 are confirmed as both potential biomarkers in diabetic nephropathy. And we further revealed the main pathways of differential genes and the differentially distributed immune infiltrating cells in diabetic nephropathy.     

离子膜电解槽优化运行

从进槽电解液及运行管理两个方面介绍离子膜电解槽的优化运行条件。