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81.
JG Izzo VA Papadimitrakopoulou XQ Li H Ibarguen JS Lee JY Ro A El-Naggar WK Hong WN Hittelman 《Canadian Metallurgical Quarterly》1998,17(18):2313-2322
Cyclin D1 proto-oncogene is a key regulator of the mammalian cell-cycle acting at the restriction point in late G1. Amplification of the cyclin D1 locus, located on chromosome 11q13, as well as cyclin D1 protein overexpression have been reported in several human malignancies. The purpose of this study was to evaluate cyclin D1 gene copy status and protein expression during the multistep process of head and neck tumorigenesis, using a combination of fluorescence in situ hybridization and immunohistochemistry techniques. From 29 selected patients presenting with head and neck squamous carcinoma and whose tumor cytospins had been previously screened for presence (16 cases) or absence (13 cases) of amplification at the 11q13 band, we analysed 46 paraffin-embedded tissue specimens that demonstrated, besides the primary tumor, the presence of contiguous adjacent normal tissue and/or premalignant lesions. Of the 16 amplified cases, nine demonstrated a continuous progression from premalignant to invasive carcinoma and seven (77.7%) of these cases showed cyclin D1 gene amplification in premalignant lesions prior to development of invasive carcinoma. Increased cyclin D1 protein expression was observed in all 16 amplified tumors and five of the 13 (38.4%) non-amplified tumors. Interestingly, dysregulated cyclin D1 expression was also found in the premalignant lesions adjacent to all 16 amplified tumors, and it appeared to precede cyclin D1 gene amplification. In contrast no dysregulated expression was detected in the premalignant lesions of the non-amplified tumors. In conclusion, these findings provide strong evidence for early dysregulation of cyclin D1 expression during the tumorigenesis process and suggest that dysregulated increased expression precedes and possibly enables gene amplification. 相似文献
82.
JK Kang SW Lee MW Baik BC Son YK Hong CK Jung KH Ryu 《Canadian Metallurgical Quarterly》1998,14(7):297-301
Accurate assessment and replacement of blood loss and fluid-electrolyte deficit during craniosynostosis repair is difficult owing to patient size and the diversity of surgical technique. Forty-three patients undergoing primary craniosynostosis repair over a 10-year period were studied retrospectively to determine blood loss and fluid deficit and to assess blood transfusion practices during both intraoperative and postoperative periods. Blood loss was calculated on the basis of estimated red cell mass (ERCM) and fluid-electrolyte imbalance was investigated with blood samplings. Blood transfusion was considered appropriate if the postoperative or posttransfusion ERCM was within 12% of the preoperative value. Estimated fluid requirement (EFR) was used in 4 ml kg(-1) h(-1) except for neonates. Intraoperatively, 80% of all patients were appropriately managed with respect to blood transfusion and EFR. Postoperatively only 20% of the patients receiving transfusions were transfused appropriately. In 23.3% of these patients (10/43) unexpected respiratory distress developed immediately after their recovery from the anesthesia. With the measurement of estimated blood volume and allowable blood loss, appropriate transfusion could be achieved for the successful treatment of the primary craniosynostosis. 相似文献
83.
研究了添加高速钢粉对烧结钢组织与性能的影响。实验结果表明,含20%高速钢的烧结钢综合力学性能最好;添加高速钢粉能导致烧结钢密度减小的冲击韧性降低,当高速钢含量增中时,硬度随之增加,烧结钢中残余奥氏体和马氏体的含量与高速钢的含量呈线性关系。烧结钢中的马氏体显微硬度很高,它主要原高速钢粒子和原铁粒子的连接区域形成。 相似文献
84.
采用钻孔灌注桩作为深地坑的围护结构,在坑内设排水沟、集水井排水。成功地在珠江三角洲地区狭窄场地进行地坑开挖,既保证了工程质量又有其特色。 相似文献
85.
86.
87.
GZ Markarian JH Lee DJ Stein SC Hong 《Canadian Metallurgical Quarterly》1996,38(3):542-50; discussion 551
The treatment of cerebral ischemia remains a formidable challenge in neuroscience today. Mild hypothermia has been shown to be an effective neuroprotective agent. Despite the great volume of published research, the therapeutic window of mild hypothermia has not been precisely elucidated. Using a model of reversible focal cerebral ischemia in the rat, this study was undertaken to define the optimal duration of hypothermic application and the maximal postischemic delay in hypothermic application before which optimal therapeutic effect is noted. Focal ischemia was induced by temporary occlusion of the middle cerebral artery and both carotid arteries in Sprague-Dawley rats for a period of 3 hours. In the first study, mild hypothermia (32-33 degrees C) was induced at the onset of ischemia in four groups of rats for varying lengths of time ranging from 1 to 4 hours. The animals were killed after 3 days, and their brains were sliced and stained. Infarcted volume was measured using a computerized image analyzer. The infarct volumes were 211 +/- 4.5, 214.2 +/- 8.0, 199.5 +/- 5.3, 171.3 +/- 9.1, and 169.8 +/- 6.5 mm3 (mean +/- standard error of the mean, n = 6 per group) for the control, 1-hour, 2-hour, 3-hour, and 4-hour groups, respectively. On the basis of the results from the above study, a 3-hour duration of hypothermia was then applied to animals at 0, 15, 30, or 45 minutes after the ischemic onset. The volumes of infarction for these four respective groups were: 171.3 +/- 9.1, 173 +/- 5.7, 179.3 +/- 5.2, and 206.2 +/- 8.4 mm3 (mean +/- standard error of the mean, n = 6 per group). These results demonstrated that optimal duration of mild hypothermia was at least 3 hours (P < 0.001) when applied within the first 30 minutes after the onset of ischemia (P < 0.001). 相似文献
88.
89.
邓寒松 《数码设计:surface》2012,(3):82-83
目前家居装饰装修市场繁荣,人们伴随着经济实力的提升而追求居住环境的舒适性、豪华性、美观性的愿望得已实现,但设计师和客户都应理性的对待居住空间的过分装饰和纯粹的美观性,应注重营造实用、绿色低碳的家居空间环境,顺应社会发展的要求。本文通过对家居空间"低碳"设计的分析,倡导家居空间环境应健康节能、选择低碳的装饰装修设计。 相似文献
90.
Hong ZHU 《Frontiers of Computer Science in China》2012,6(1):40-56
Meta-modelling plays an important role in model driven software development.In this paper,a graphic extension of BNF (GEBNF) is proposed to define the abstract syntax of graphic modelling languages.Fro... 相似文献